Prediction of Solute Kinetics, Acid-Base Status, and Blood Volume Changes During Profiled Hemodialysis

10.1114/1.245 ◽  
2000 ◽  
Vol 28 (2) ◽  
pp. 204-216 ◽  
Author(s):  
M. Ursino ◽  
L. Colí ◽  
C. Brighenti ◽  
L. Chiari ◽  
A. De Pascalis ◽  
...  
Keyword(s):  
Blood Volume ◽  
Volume Changes ◽  
Acid Base ◽  
Acid Base Status

scholarly journals Haemodynamic, acid–base and blood volume changes during prolonged low pressure pneumoperitoneum in rabbits

2006 ◽  
Vol 96 (5) ◽  
pp. 563-568 ◽  
Author(s):  
R. Sümpelmann ◽  
T. Schuerholz ◽  
G. Marx ◽  
D. Härtel ◽  
H. Hecker ◽  
...  
Keyword(s):  
Blood Volume ◽  
Low Pressure ◽  
Volume Changes ◽  
Acid Base

scholarly journals Acid-Base Regulation in the Atlantic Hagfish Myxine Glutinosa

1991 ◽  
Vol 161 (1) ◽  
pp. 201-215 ◽  
Author(s):  
D. G. McDONALD ◽  
V. CAVDEK ◽  
L. CALVERT ◽  
C. L. MLLLIGAN
Keyword(s):  
Sulphuric Acid ◽  
Blood Volume ◽  
Ammonium Sulphate ◽  
Extracellular Space ◽  
External Environment ◽  
Buffering Capacity ◽  
Acid Excretion ◽  
Acid Base ◽  
Myxine Glutinosa ◽  
Acid Base Status

Blood acid-base status and net transfers of acidic equivalents to the external environment were studied in hagfish, Myxine glutinosa, infused with ammonium sulphate (4mequivkg−1 NH4+) or with sulphuric acid (3mequiv kg−1 H+). Hagfish extracellular fluids (ECF) play a greater role in acid-base regulation than in teleosts. This is because hagfish have a much larger blood volume relative to teleosts, despite a relatively low blood buffering capacity. Consequently, infusion of ammonium sulphate produced only half of the acidosis produced in marine teleosts in comparable studies, and hagfish readily tolerated a threefold greater direct H+ load. Furthermore, the H+ load was largely retained and buffered in the extracellular space. Despite smaller acid-base disturbances, rates of net H+ excretion to the external environment were, nonetheless, comparable to those of marine teleosts, and net acid excretion persisted until blood acid-base disturbances were corrected. We conclude that the gills of the hagfish are at least as competent for acid-base regulation as those of marine teleosts. The nature of the H+ excretion mechanism is discussed.

Acute hemorrhage in dogs: construction and validation of models to quantify blood loss

1993 ◽  
Vol 74 (2) ◽  
pp. 510-519 ◽  
Author(s):  
Y. Waisman ◽  
P. Q. Eichacker ◽  
S. M. Banks ◽  
W. D. Hoffman ◽  
T. J. MacVittie ◽  
...  
Keyword(s):  
Blood Loss ◽  
Blood Volume ◽  
Linear Regression Analysis ◽  
Base Deficit ◽  
Prediction Errors ◽  
Volume Changes ◽  
Acid Base ◽  
Acute Hemorrhage ◽  
Base Parameters ◽  
Analysis Models

We examined the ability of commonly used clinical parameters to quantify acute hemorrhage in dogs. Eight animals were bled 40 ml/kg body wt over 100 min. Ten hemodynamic and 20 blood laboratory parameters were obtained every 10 min to construct, with use of linear regression analysis, models that quantify blood loss. During model construction, the best indicator of quantity of hemorrhage was arterial base deficit [ABD; coefficient of variation (CV) 35%]. This model was more accurate (P < 0.05) than 27 others (CV range 43 to 63%) and similar to systolic (CV 40%) and mean (CV 40%) arterial pressures. In validation studies in 10 additional animals, our best models based on ABD and systolic and mean arterial pressures each unexpectedly showed a significant (P < 0.05) decrease in accuracy (CV 86, 57, and 60%, respectively) attributable to large baseline (before hemorrhage) variability among animals. To eliminate this variability, models based on changes from baseline measurements were investigated. The best predictor of change in blood volume was change in ABD (CV 27%). This model was significantly (P < 0.05) more accurate than any of 27 others (CV range 36 to 65%) and similar to change in venous base deficit and venous pH (each CV 31%). When validated, acid-base models such as ABD, venous pH, and arterial bicarbonate were the best predictors of volume change (CV range 28 to 40%). With the use of multivariate analysis, pairwise combinations of single parameter models (n = 465) improved prediction errors only minimally. In summary, most commonly used hemodynamic and blood indexes could not be validated as accurate measurements in quantifying hemorrhage. In contrast, changes in acid-base parameters were validated as moderately accurate predictors of blood volume changes and therefore may have utility in the assessment of patients with ongoing hemorrhage.

scholarly journals 991 CAPILLARY VENOUS HEMATOCRIT DIFFERENCE IN NEWBORN INFANTS: RELATION TO BLOOD VOLUME, PERIPHERAL BLOOD FLOW, AND ACID BASE STATUS

1978 ◽  
Vol 12 ◽  
pp. 529-529
Author(s):  
Otwin Linderkamp ◽  
Hans T Versmold ◽  
Irmela Strohhacker ◽  
Karin Messow-Zahn ◽  
Klaus P Riegel ◽  
...  
Keyword(s):  
Blood Flow ◽  
Blood Volume ◽  
Peripheral Blood ◽  
Newborn Infants ◽  
Peripheral Blood Flow ◽  
Acid Base ◽  
Acid Base Status

To Manage Infantile Hypertrophic Pyloric Stenosis by "Double-Y Pyloromyotomy" is a better Surgical Approach

2014 ◽  
Vol 1 (2) ◽  
pp. 143-147
Author(s):  
Md. Ansar Ali ◽  
Kaniz Hasina ◽  
Shahnoor Islam ◽  
Md. Ashraf Ul Huq ◽  
Md. Mahbub-Ul Alam ◽  
...  
Keyword(s):  
Weight Gain ◽  
Pyloric Stenosis ◽  
Hypertrophic Pyloric Stenosis ◽  
Treatment Modalities ◽  
Infantile Hypertrophic Pyloric Stenosis ◽  
Postoperative Vomiting ◽  
Acid Base ◽  
Feeding Regimes ◽  
Acid Base Status ◽  
Postoperative Feeding

Background: Different treatment modalities and procedures have been tried for the management of infantile hypertrophic pyloric stenosis. But surgery remains the mainstay for management of IHPS. Ramstedt’s pyloromyotomy was described almost over a hundred years ago and to date remains the surgical technique of choice. An alternative and better technique is the double-Y pyloromyotomy, which offer better results for management of this common condition.Methods: A prospective comparative interventional study of 40 patients with IHPS was carried out over a period of 2 years from July 2008 to July 2010. The patients were divided into 2 equal groups of 20 patients in each. The study was designed that all patients selected for study were optimized preoperatively regarding to hydration, acid-base status and electrolytes imbalance. All surgeries were performed after obtaining informed consent. Standard preoperative preparation and postoperative feeding regimes were used. The patients were operated on an alternate basis, i.e., one patient by Double-Y Pyloromyotomy(DY) and the next by aRamstedt’s Pyloromyotomy (RP). Data on patient demographics, operative time, anesthesia complications, postoperative complications including vomiting and weight gain were collected. Patients were followed up for a period of 3 months postoperatively. Statistical assessments were done by using t test.Results: From July 2008 through July 2010, fourty patients were finally analyzed for this study. Any statistical differences were observed in patient population regarding age, sex, weight at presentation, symptoms and clinical condition including electrolytes imbalance and acid-base status were recorded. Significant differences were found in postoperative vomiting and weight gain. Data of post operative vomiting and weight gain in both groups were collected. Vomiting in double-Y(DY) pyloromyotomy group (1.21 ± 0.45days) vs Ramstedt’s pyloromyotomy (RP) group(3.03 ± 0.37days) p= 0.0001.Weight gain after 1st 10 days DY vs RP is ( 298 ± 57.94 gm vs193±19.8 gm p=0.0014), after 1 month (676.67±149.84 gm vs 466.67 ± 127.71 gm, p=0.0001), after 2months (741.33± 278.74 gm vs 490±80.62 gm, p=0.002) and after 3 months (582±36.01gm vs 453.33±51.64 gm, p=0.0001).No long-term complications were reported and no re-do yloromyotomy was needed.Conclusion: The double-Y pyloromyotomy seems to be a better technique for the surgical management of IHPS. It may offer a better functional outcome in term of postoperative vomiting and weight gain.DOI: http://dx.doi.org/10.3329/jpsb.v1i2.19532

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