scholarly journals Greater impairments in cerebral artery compared with skeletal muscle feed artery endothelial function in a mouse model of increased large artery stiffness

2015 ◽  
Vol 593 (8) ◽  
pp. 1931-1943 ◽  
Author(s):  
Ashley E. Walker ◽  
Grant D. Henson ◽  
Kelly D. Reihl ◽  
R. Garrett Morgan ◽  
Parker S. Dobson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Endothelial Function ◽  
Cerebral Artery ◽  
Large Artery ◽  
Artery Stiffness

scholarly journals Cerebral and skeletal muscle feed artery vasoconstrictor responses in a mouse model with greater large elastic artery stiffness

2019 ◽  
Vol 104 (3) ◽  
pp. 434-442 ◽  
Author(s):  
Ashley E. Walker ◽  
Elise K. Kronquist ◽  
Kerrick T. Chinen ◽  
Kelly D. Reihl ◽  
Dean Y. Li ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Artery Stiffness ◽  
Elastic Artery

scholarly journals Hippocampal Perfusion in a Mouse Model of Greater Large Artery Stiffness and Alzheimer’s Disease‐Related Transgenes

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Nicholas R. Winder ◽  
Grant D. Henson ◽  
Martin M. Pike ◽  
Ashley E. Walker
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Large Artery ◽  
Artery Stiffness

scholarly journals Effects of Pyridoxamine Treatment on Large Artery Stiffness, Endothelial Function, and Cognitive Impairment in Old Mice

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Emily Reeve ◽  
Elise Kronquist ◽  
Julia Wolf ◽  
Byron Lee ◽  
Aleena Khurana ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Endothelial Function ◽  
Large Artery ◽  
Artery Stiffness ◽  
Old Mice

scholarly journals Heart rate-associated mechanical stress impairs carotid but not cerebral artery compliance in dyslipidemic atherosclerotic mice

2011 ◽  
Vol 301 (5) ◽  
pp. H2081-H2092 ◽  
Author(s):  
Virginie Bolduc ◽  
Annick Drouin ◽  
Marc-Antoine Gillis ◽  
Natacha Duquette ◽  
Nathalie Thorin-Trescases ◽  
...  
Keyword(s):  
Heart Rate ◽  
Endothelial Dysfunction ◽  
Carotid Artery ◽  
Endothelial Function ◽  
Mechanical Stress ◽  
Cerebral Artery ◽  
Carotid Arteries ◽  
Cerebral Arteries ◽  
Artery Stiffness ◽  
Dependent Flow

The cardiac cycle imposes a mechanical stress that dilates elastic carotid arteries, while shear stress largely contributes to the endothelium-dependent dilation of downstream cerebral arteries. In the presence of dyslipidemia, carotid arteries stiffen while the endothelial function declines. We reasoned that stiffening of carotid arteries would be prevented by reducing resting heart rate (HR), while improving the endothelial function would regulate cerebral artery compliance and function. Thus we treated or not 3-mo-old male atherosclerotic mice (ATX; LDLr-/−:hApoB+/+) for 3 mo with the sinoatrial pacemaker current inhibitor ivabradine (IVA), the β-blocker metoprolol (METO), or subjected mice to voluntary physical training (PT). Arterial (carotid and cerebral artery) compliance and endothelium-dependent flow-mediated cerebral dilation were measured in isolated pressurized arteries. IVA and METO similarly reduced ( P < 0.05) 24-h HR by ≈15%, while PT had no impact. As expected, carotid artery stiffness increased ( P < 0.05) in ATX mice compared with wild-type mice, while cerebral artery stiffness decreased ( P < 0.05); this paradoxical increase in cerebrovascular compliance was associated with endothelial dysfunction and an augmented metalloproteinase-9 (MMP-9) activity ( P < 0.05), without changing the lipid composition of the wall. Reducing HR (IVA and METO) limited carotid artery stiffening, but plaque progression was prevented by IVA only. In contrast, IVA maintained and PT improved cerebral endothelial nitric oxide synthase-dependent flow-mediated dilation and wall compliance, and both interventions reduced MMP-9 activity ( P < 0.05); METO worsened endothelial dysfunction and compliance and did not reduce MMP-9 activity. In conclusion, HR-dependent mechanical stress contributes to carotid artery wall stiffening in severely dyslipidemic mice while cerebrovascular compliance is mostly regulated by the endothelium.

scholarly journals The slope of cerebral oxyhemoglobin oscillation is associated with vascular reserve capacity in large artery steno-occlusion

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tae Jung Kim ◽  
Jae-Myoung Kim ◽  
Soo-Hyun Park ◽  
Jong-Kwan Choi ◽  
Hyeon-Min Bae ◽  
...  
Keyword(s):  
Cerebral Artery ◽  
Near Infrared ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Large Artery ◽  
Anterior Circulation ◽  
Functional Near Infrared Spectroscopy ◽  
Vascular Reserve ◽  
Photon Emission Computed Tomography

AbstractInadequate cerebral perfusion is a risk factor for cerebral ischemia in patients with large artery steno-occlusion. We investigated whether prefrontal oxyhemoglobin oscillation (ΔHbO2, 0.6–2 Hz) was associated with decreased vascular reserve in patients with steno-occlusion in the large anterior circulation arteries. Thirty-six patients with steno-occlusion in the anterior circulation arteries (anterior cerebral artery, middle cerebral artery, and internal carotid artery) were included and compared to thirty-six control subjects. Patients were categorized into two groups (deteriorated vascular reserve vs. preserved vascular reserve) based on the results of Diamox single- photon emission computed tomography imaging. HbO2 data were collected using functional near-infrared spectroscopy. The slope of ΔHbO2 and the ipsilateral/contralateral slope ratio of ΔHbO2 were analyzed. Among the included patients (n = 36), 25 (69.4%) had deteriorated vascular reserve. Patients with deteriorated vascular reserve had a significantly higher average slope of ΔHbO2 on the ipsilateral side (5.01 ± 2.14) and a higher ipsilateral/contralateral ratio (1.44 ± 0.62) compared to those with preserved vascular reserve (3.17 ± 1.36, P = 0.014; 0.93 ± 0.33, P = 0.016, respectively) or the controls (3.82 ± 1.69, P = 0.019; 0.94 ± 0.29, P = 0.001). The ipsilateral/contralateral ΔHbO2 ratio could be used as a surrogate for vascular reserve in patients with severe steno-occlusion in the anterior circulation arteries.

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