scholarly journals Cerebral and skeletal muscle feed artery vasoconstrictor responses in a mouse model with greater large elastic artery stiffness

2019 ◽  
Vol 104 (3) ◽  
pp. 434-442 ◽  
Author(s):  
Ashley E. Walker ◽  
Elise K. Kronquist ◽  
Kerrick T. Chinen ◽  
Kelly D. Reihl ◽  
Dean Y. Li ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Artery Stiffness ◽  
Elastic Artery

scholarly journals Greater impairments in cerebral artery compared with skeletal muscle feed artery endothelial function in a mouse model of increased large artery stiffness

2015 ◽  
Vol 593 (8) ◽  
pp. 1931-1943 ◽  
Author(s):  
Ashley E. Walker ◽  
Grant D. Henson ◽  
Kelly D. Reihl ◽  
R. Garrett Morgan ◽  
Parker S. Dobson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Endothelial Function ◽  
Cerebral Artery ◽  
Large Artery ◽  
Artery Stiffness

Abstract P105: Greater 24 Hour Blood Pressure Variability is Associated With Higher 24 Hour Systolic Blood Pressure and Glucose Independent of Age and Large Elastic Artery Stiffness in Normotensive Adults

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Lyndsey E DuBose ◽  
Seth W Holwerda ◽  
Amy K Stroud ◽  
Nealy A Wooldridge ◽  
Janie E Myers ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
Blood Glucose ◽  
Carotid Artery ◽  
Linear Regression ◽  
Fasting Blood Glucose ◽  
Large Artery ◽  
Stepwise Linear Regression ◽  
Artery Stiffness ◽  
Elastic Artery

Older age is associated with elevated large elastic artery stiffness, a strong predictor of cardiovascular (CVD) risk in middle-age/older (MA/O) adults independent of blood pressure (BP). Greater 24-hour systolic BP variability (BPV) is also an independent risk factor for CVD and is linked to large artery stiffness in MA/O adults with hypertension and diabetes. However, its relation to age-related arterial stiffness in adults with low risk factor burden is unclear. We hypothesized that higher systolic BPV would be: 1) associated with advancing age, and 2) related to elevated aortic and carotid artery stiffness among healthy MA/O adults. To determine this, 98 healthy adults (ages 19-70 yrs) with measurements of systolic BPV (standard deviation of 24 hr systolic BP) via ambulatory BP monitoring, aortic stiffness (carotid-femoral pulse wave velocity, cfPWV), carotid artery stiffness (β-stiffness via carotid tonometry/B mode ultrasound) and circulating metabolic factors were included. In the entire cohort, greater systolic BPV was not associated with age, cfPWV, carotid β stiffness or circulating lipids/glucose (all P>0.05), but was correlated (age-adjusted) with 24 hr systolic BP (r= 0.41, P<0.001) and BMI (r= 0.21, P<0.05). In stepwise linear regression analyses that included age, sex, BMI, only 24 hr systolic BP was associated with systolic BPV (β= 0.14 ± 0.03, Model R 2 = 0.20, P< 0.001). Interestingly, there was no difference in 24 hr systolic BPV (11.4 ± 0.4 vs 11.4 ± 0.5 SD mmHg, P=0.99) in young (n=55; 29.0 ± 0.7 yrs) vs. MA/O (n= 43; 53.0 ± 1.2 yrs) adults despite higher cfPWV (594 ± 12 vs 913 ± 39 cm/sec, P<0.001), carotid β-stiffness (6.8 ± 0.6 vs 9.3 ±0.9 U, P=0.001) and 24 hr systolic BP (121 ± 1 vs 125 ± 2 mmHg, P<0.05). Systolic BPV was associated with BMI (r= 0.42, p< 0.01) and fasting blood glucose (r= 0.54, P= 0.001) in MA/O but not young adults. In a stepwise linear regression model among MA/O, 24 hr systolic BP (β= 0.18 ± 0.04, R 2 = 0.36, P<0.001) and fasting glucose (β= 0.10 ± 0.05, R 2 change= 0.07, P<0.001) were the only significant correlates of systolic BPV (Model R 2 = 0.43, P<0.001). In conclusion, 24 hr systolic BP and fasting blood glucose, but not age or large elastic artery stiffness, were the strongest determinants of higher systolic BPV in normotensive MA/O adults.

scholarly journals Nuclear defects in skeletal muscle from a Dynamin 2-linked centronuclear myopathy mouse model

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Anaïs Fongy ◽  
Sestina Falcone ◽  
Jeanne Lainé ◽  
Bernard Prudhon ◽  
Aurea Martins-Bach ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Centronuclear Myopathy ◽  
Dynamin 2

scholarly journals Dysregulated mitochondrial Ca2+ and ROS signaling in skeletal muscle of ALS mouse model

2019 ◽  
Vol 663 ◽  
pp. 249-258 ◽  
Author(s):  
Jingsong Zhou ◽  
Ang Li ◽  
Xuejun Li ◽  
Jianxun Yi
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Ros Signaling

scholarly journals A Skeletal Muscle Conditional KCNJ2 Knock-Out Mouse Model for Periodic Paralysis in Andersen-Tawil Syndrome

2019 ◽  
Vol 116 (3) ◽  
pp. 242a
Author(s):  
Nathaniel Elia ◽  
Ekaterina Mokhonova ◽  
Marbella Quinonez ◽  
Stephen Cannon
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Periodic Paralysis ◽  
Knock Out ◽  
Knock Out Mouse

scholarly journals ROS-related mitochondrial dysfunction in skeletal muscle of an ALS mouse model during the disease progression

2018 ◽  
Vol 138 ◽  
pp. 25-36 ◽  
Author(s):  
Yajuan Xiao ◽  
Chehade Karam ◽  
Jianxun Yi ◽  
Lin Zhang ◽  
Xuejun Li ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Mitochondrial Dysfunction ◽  
Disease Progression
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