scholarly journals Climbing-fibre activation of NMDA receptors in Purkinje cells of adult mice

2007 ◽  
Vol 585 (1) ◽  
pp. 91-101 ◽  
Author(s):  
Massimiliano Renzi ◽  
Mark Farrant ◽  
Stuart G. Cull-Candy
Keyword(s):  
Nmda Receptors ◽  
Purkinje Cells ◽  
Climbing Fibre ◽  
Adult Mice

scholarly journals Spike timing-dependent selective strengthening of single climbing fibre inputs to Purkinje cells during cerebellar development

2013 ◽  
Vol 4 (1) ◽  
Author(s):  
Yoshinobu Kawamura ◽  
Hisako Nakayama ◽  
Kouichi Hashimoto ◽  
Kenji Sakimura ◽  
Kazuo Kitamura ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Spike Timing ◽  
Cerebellar Development ◽  
Climbing Fibre

Incomplete regression of multiple climbing fibre innervation of cerebellar Purkinje cells in mGluR1 mutant mice

Neuroreport ◽  
1997 ◽  
Vol 8 (2) ◽  
pp. 571-574 ◽  
Author(s):  
Carole Levenes ◽  
Hervé Daniel ◽  
Danielle Jaillard ◽  
François Conquet ◽  
François Crépel
Keyword(s):  
Purkinje Cells ◽  
Mutant Mice ◽  
Climbing Fibre ◽  
Cerebellar Purkinje Cells

Cerebellar cortex

2020 ◽  
pp. 497-504
Author(s):  
Edmund T. Rolls
Keyword(s):  
Purkinje Cell ◽  
Purkinje Cells ◽  
Cerebellar Cortex ◽  
Network Architecture ◽  
Granule Cells ◽  
Feedforward Control ◽  
Synaptic Depression ◽  
Climbing Fibre ◽  
Regular Sampling

The cerebellar cortex appears to be involved in predictive feedforward control to generate smooth movements. There is a beautiful network architecture which suggests that the granule cells perform expansion recoding of the inputs; that these connect to the Purkinje cells via an architecture that ensures regular sampling; and that each Purkinje cell has a single teacher, the climbing fibre, which produces associative long-term synaptic depression as part of perceptron-like learning.

Climbing fibre activation of Purkinje cells in the frog cerebellum

1967 ◽  
Vol 3 (3) ◽  
pp. 299-302 ◽  
Author(s):  
R. Llina´s ◽  
J. Bloedel
Keyword(s):  
Purkinje Cells ◽  
Climbing Fibre ◽  
Frog Cerebellum

scholarly journals NMDA receptors are the basis for persistent network activity in neocortex slices

2015 ◽  
Vol 113 (10) ◽  
pp. 3816-3826 ◽  
Author(s):  
Manuel A. Castro-Alamancos ◽  
Morgana Favero
Keyword(s):  
Nmda Receptors ◽  
Input Resistance ◽  
Network Activity ◽  
Resting Membrane Potential ◽  
Persistent Activity ◽  
Cortical Cells ◽  
Optogenetic Stimulation ◽  
Adult Mice ◽  
Up States ◽  
Intrinsic Firing

During behavioral quiescence the neocortex generates spontaneous slow oscillations that consist of Up and Down states. Up states are short epochs of persistent activity, but their underlying source is unclear. In neocortex slices of adult mice, we monitored several cellular and network variables during the transition between a traditional buffer, which does not cause Up states, and a lower-divalent cation buffer, which leads to the generation of Up states. We found that the resting membrane potential and input resistance of cortical cells did not change with the development of Up states. The synaptic efficacy of excitatory postsynaptic potentials mediated by non-NMDA receptors was slightly reduced, but this is unlikely to facilitate the generation of Up states. On the other hand, we identified two variables that are associated with the generation of Up states: an enhancement of the intrinsic firing excitability of cortical cells and an enhancement of NMDA-mediated responses evoked by electrical or optogenetic stimulation. The fact that blocking NMDA receptors abolishes Up states indicates that the enhancement in intrinsic firing excitability alone is insufficient to generate Up states. NMDA receptors have a crucial role in the generation of Up states in neocortex slices.

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