scholarly journals Interaction between responses in Purkinje cells evoked by climbing fibre impulses and parallel fibre volleys in the cat.

1983 ◽  
Vol 340 (1) ◽  
pp. 225-238 ◽  
Author(s):  
N C Campbell ◽  
C F Ekerot ◽  
G Hesslow
Keyword(s):  
Purkinje Cells ◽  
Parallel Fibre ◽  
Climbing Fibre

scholarly journals Spike timing-dependent selective strengthening of single climbing fibre inputs to Purkinje cells during cerebellar development

2013 ◽  
Vol 4 (1) ◽  
Author(s):  
Yoshinobu Kawamura ◽  
Hisako Nakayama ◽  
Kouichi Hashimoto ◽  
Kenji Sakimura ◽  
Kazuo Kitamura ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Spike Timing ◽  
Cerebellar Development ◽  
Climbing Fibre

Incomplete regression of multiple climbing fibre innervation of cerebellar Purkinje cells in mGluR1 mutant mice

Neuroreport ◽  
1997 ◽  
Vol 8 (2) ◽  
pp. 571-574 ◽  
Author(s):  
Carole Levenes ◽  
Hervé Daniel ◽  
Danielle Jaillard ◽  
François Conquet ◽  
François Crépel
Keyword(s):  
Purkinje Cells ◽  
Mutant Mice ◽  
Climbing Fibre ◽  
Cerebellar Purkinje Cells

scholarly journals The origin of physiological local mGluR1 supralinear Ca2+ signals in cerebellar Purkinje neurons

2019 ◽  
Author(s):  
Karima Ait Ouares ◽  
Marco Canepari
Keyword(s):  
Synaptic Plasticity ◽  
Metabotropic Glutamate Receptors ◽  
Purkinje Neurons ◽  
Parallel Fibre ◽  
Climbing Fibre ◽  
Metabotropic Glutamate ◽  
Type K ◽  
Cerebellar Purkinje Neurons ◽  
Crucial Parameter

SUMMARYIn Purkinje neurons, the climbing fibre (CF) input provides a signal to parallel fibre (PF) synapses triggering PF synaptic plasticity. This supralinear Ca2+ signal, co-localised with the PF Ca2+ influx, occurs when PF activity precedes the CF input. Using membrane potential (Vm) and Ca2+ imaging, we identified the biophysical determinants of these supralinear Ca2+ signals. The CF-associated Ca2+ influx is mediated by T-type or by P/Q-type Ca2+ channels, depending on whether the dendritic Vm is hyperpolarised or depolarised. The resulting Ca2+ elevation is locally amplified by saturation of the endogenous Ca2+ buffer produced by the PF-associated Ca2+ influx, in particular by the slow Ca2+ influx mediated by type-1 metabotropic glutamate receptors (mGluR1s). When the dendrite is hyperpolarised, mGluR1s boost neighbouring T-type channels providing a mechanism for local coincident detection of PF-CF activity. In contrast, when the dendrite is depolarised, mGluR1s increase dendritic excitability by inactivating A-type K+ channels, but this phenomenon is not restricted to the activated PF synapses. Thus, Vm is likely a crucial parameter in determining PF synaptic plasticity and the occurrence of hyperpolarisation episodes is expected to play an important role in motor learning.

Cerebellar cortex

2020 ◽  
pp. 497-504
Author(s):  
Edmund T. Rolls
Keyword(s):  
Purkinje Cell ◽  
Purkinje Cells ◽  
Cerebellar Cortex ◽  
Network Architecture ◽  
Granule Cells ◽  
Feedforward Control ◽  
Synaptic Depression ◽  
Climbing Fibre ◽  
Regular Sampling

The cerebellar cortex appears to be involved in predictive feedforward control to generate smooth movements. There is a beautiful network architecture which suggests that the granule cells perform expansion recoding of the inputs; that these connect to the Purkinje cells via an architecture that ensures regular sampling; and that each Purkinje cell has a single teacher, the climbing fibre, which produces associative long-term synaptic depression as part of perceptron-like learning.

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