scholarly journals Spike timing-dependent selective strengthening of single climbing fibre inputs to Purkinje cells during cerebellar development

2013 ◽  
Vol 4 (1) ◽  
Author(s):  
Yoshinobu Kawamura ◽  
Hisako Nakayama ◽  
Kouichi Hashimoto ◽  
Kenji Sakimura ◽  
Kazuo Kitamura ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Spike Timing ◽  
Cerebellar Development ◽  
Climbing Fibre

Effects of insulin-like growth factor I on climbing fibre synapse elimination during cerebellar development

2003 ◽  
Vol 17 (3) ◽  
pp. 545-554 ◽  
Author(s):  
Sho Kakizawa ◽  
Kazuyuki Yamada ◽  
Masamitsu Iino ◽  
Masahiko Watanabe ◽  
Masanobu Kano
Keyword(s):  
Growth Factor ◽  
Cerebellar Development ◽  
Insulin Like Growth Factor ◽  
Synapse Elimination ◽  
Climbing Fibre ◽  
Factor I ◽  
Growth Factor I

scholarly journals Preterm Birth Impedes Structural and Functional Development of Cerebellar Purkinje Cells in the Developing Baboon Cerebellum

2020 ◽  
Vol 10 (12) ◽  
pp. 897
Author(s):  
Tara Barron ◽  
Jun Hee Kim
Keyword(s):  
Preterm Birth ◽  
Action Potential ◽  
Purkinje Cell ◽  
Purkinje Cells ◽  
Late Gestation ◽  
Cerebellar Development ◽  
Layer Width ◽  
Action Potential Waveform ◽  
Developmental Features ◽  
Potential Waveform

Human cerebellar development occurs late in gestation and is hindered by preterm birth. The fetal development of Purkinje cells, the primary output cells of the cerebellar cortex, is crucial for the structure and function of the cerebellum. However, morphological and electrophysiological features in Purkinje cells at different gestational ages, and the effects of neonatal intensive care unit (NICU) experience on cerebellar development are unexplored. Utilizing the non-human primate baboon cerebellum, we investigated Purkinje cell development during the last trimester of pregnancy and the effect of NICU experience following premature birth on developmental features of Purkinje cells. Immunostaining and whole-cell patch clamp recordings of Purkinje cells in the baboon cerebellum at different gestational ages revealed that molecular layer width, driven by Purkinje dendrite extension, drastically increased and refinement of action potential waveform properties occurred throughout the last trimester of pregnancy. Preterm birth followed by NICU experience for 2 weeks impeded development of Purkinje cells, including action potential waveform properties, synaptic input, and dendrite extension compared with age-matched controls. In addition, these alterations impact Purkinje cell output, reducing the spontaneous firing frequency in deep cerebellar nucleus (DCN) neurons. Taken together, the primate cerebellum undergoes developmental refinements during late gestation, and NICU experience following extreme preterm birth influences morphological and physiological features in the cerebellum that can lead to functional deficits.

scholarly journals Lrp5/6 are required for cerebellar development and for suppressing TH expression in Purkinje cells via β-catenin

2016 ◽  
Vol 9 (1) ◽  
Author(s):  
Ying Huang ◽  
Qiong Zhang ◽  
Ning-Ning Song ◽  
Lei Zhang ◽  
Yu-Ling Sun ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Cerebellar Development

scholarly journals Calcium-dependent regulation of climbing fibre synapse elimination during postnatal cerebellar development

2013 ◽  
Vol 591 (13) ◽  
pp. 3151-3158 ◽  
Author(s):  
Masanobu Kano ◽  
Hisako Nakayama ◽  
Kouichi Hashimoto ◽  
Kazuo Kitamura ◽  
Kenji Sakimura ◽  
...  
Keyword(s):  
Cerebellar Development ◽  
Synapse Elimination ◽  
Climbing Fibre ◽  
Calcium Dependent

Incomplete regression of multiple climbing fibre innervation of cerebellar Purkinje cells in mGluR1 mutant mice

Neuroreport ◽  
1997 ◽  
Vol 8 (2) ◽  
pp. 571-574 ◽  
Author(s):  
Carole Levenes ◽  
Hervé Daniel ◽  
Danielle Jaillard ◽  
François Conquet ◽  
François Crépel
Keyword(s):  
Purkinje Cells ◽  
Mutant Mice ◽  
Climbing Fibre ◽  
Cerebellar Purkinje Cells
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