scholarly journals Ventilatory responses and carotid body function in adult rats perinatally exposed to hyperoxia

2003 ◽  
Vol 554 (1) ◽  
pp. 126-144 ◽  
Author(s):  
J. Prieto-Lloret ◽  
A. I. Caceres ◽  
A. Obeso ◽  
A. Rocher ◽  
R. Rigual ◽  
...  
Keyword(s):  
Carotid Body ◽  
Adult Rats ◽  
Body Function ◽  
Ventilatory Responses

scholarly journals Carotid body function and ventilatory responses in intermittent hypoxia. evidence for anomalous brainstem integration of arterial chemoreceptor input

2011 ◽  
Vol 226 (8) ◽  
pp. 1961-1969 ◽  
Author(s):  
M.C. Gonzalez-Martín ◽  
M.V. Vega-Agapito ◽  
S.V. Conde ◽  
J. Castañeda ◽  
R. Bustamante ◽  
...  
Keyword(s):  
Carotid Body ◽  
Intermittent Hypoxia ◽  
Body Function ◽  
Ventilatory Responses ◽  
Arterial Chemoreceptor

scholarly journals Hypoxic pulmonary vasoconstriction, carotid body function and erythropoietin production in adult rats perinatally exposed to hyperoxia

2015 ◽  
Vol 593 (11) ◽  
pp. 2459-2477 ◽  
Author(s):  
Jesus Prieto-Lloret ◽  
Maria Ramirez ◽  
Elena Olea ◽  
Javier Moral-Sanz ◽  
Angel Cogolludo ◽  
...  
Keyword(s):  
Carotid Body ◽  
Hypoxic Pulmonary Vasoconstriction ◽  
Adult Rats ◽  
Body Function ◽  
Pulmonary Vasoconstriction ◽  
Erythropoietin Production

scholarly journals Bilateral Carotid Endarterectomy with Attempted Preservation of Carotid Body Function

1972 ◽  
Vol 175 (2) ◽  
pp. 268-273 ◽  
Author(s):  
Robert F. Hickey ◽  
William K. Ehrenfeld ◽  
F. Norman Hamilton ◽  
C. Philip Labson
Keyword(s):  
Carotid Endarterectomy ◽  
Carotid Body ◽  
Body Function ◽  
Bilateral Carotid

Predominant role of peripheral chemoreceptors in the termination of apnea in maturing newborn lambs

1996 ◽  
Vol 80 (3) ◽  
pp. 892-898 ◽  
Author(s):  
C. Delacourt ◽  
E. Canet ◽  
M. A. Bureau
Keyword(s):  
Carotid Body ◽  
Pco2 Level ◽  
Peripheral Chemoreceptor ◽  
Arterial Pco2 ◽  
Postnatal Maturation ◽  
Body Function ◽  
Life Threatening ◽  
Prolonged Apnea ◽  
Arterial Po2

Apneas are very common and normal in newborns but may become life threatening if they are not terminated appropriately. The aim of this study in newborn lambs was to investigate the influence on apnea termination of postnatal maturation, peripheral chemoreceptor function, and hypoxia. Apneas were induced by passive hyperventilation at varying inspired O2 fraction levels. The apnea termination threshold PCO2 (PATTCO2) was defined as the arterial PCO2 value at the first breath after the apnea. Three groups of awake intubated lambs were studied: 1) intact lambs tested at both 1 and 15 days of life, 2) intact 1-day-old lambs with central tissue hypoxia induced by CO inhalation, and 3) 1-day-old lambs with carotid body denervation (CBD). In individual lambs and regardless of age and carotid body function, there was a PO2-PCO2 response curve that was a determinant for the termination of an apnea. PATTCO2 invariably increased when arterial PO2 increased, regardless of age. During hypoxia and normoxia, PATTCO2 was significantly lower in 15-day-old lambs compared with 1-day-old lambs. No difference was seen during hyperoxia. PATTCO2 values were shifted to higher levels after carotid body removal. Finally, hypoxia induced by either a low inspired O2 fraction or CO inhalation consistently failed to induce a depressive effect on the PATTCO2 even in CBD lambs. In conclusion, in awake newborn lambs, the PCO2 level for apnea termination changed with postnatal age, and carotid body function was essential in lowering PATTCO2, thus protecting the lambs against prolonged apnea. Furthermore, hypoxia consistently failed to depress the reinitiation of breathing after apnea, even in CBD lambs.

scholarly journals Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2

2013 ◽  
Vol 591 (14) ◽  
pp. 3565-3577 ◽  
Author(s):  
Tammie Bishop ◽  
Nick P. Talbot ◽  
Philip J. Turner ◽  
Lynn G. Nicholls ◽  
Alberto Pascual ◽  
...  
Keyword(s):  
Carotid Body ◽  
Ventilatory Responses ◽  
Heterozygous Deficiency

Altered carotid body function by intermittent hypoxia in neonates and adults: Relevance to recurrent apneas

2007 ◽  
Vol 157 (1) ◽  
pp. 148-153 ◽  
Author(s):  
Nanduri R. Prabhakar ◽  
Yin-Jie Peng ◽  
Ganesh K. Kumar ◽  
Anita Pawar
Keyword(s):  
Carotid Body ◽  
Intermittent Hypoxia ◽  
Body Function

scholarly journals Endogenous H2S is required for hypoxic sensing by carotid body glomus cells

2012 ◽  
Vol 303 (9) ◽  
pp. C916-C923 ◽  
Author(s):  
Vladislav V. Makarenko ◽  
Jayasri Nanduri ◽  
Gayatri Raghuraman ◽  
Aaron P. Fox ◽  
Moataz M. Gadalla ◽  
...  
Keyword(s):  
Carotid Body ◽  
Time Course ◽  
Channel Blocker ◽  
Primary Site ◽  
Dependent Manner ◽  
Free Medium ◽  
Adult Rats ◽  
Glomus Cells ◽  
Dose Dependent ◽  
Carotid Body Glomus Cells

H2S generated by the enzyme cystathionine-γ-lyase (CSE) has been implicated in O2 sensing by the carotid body. The objectives of the present study were to determine whether glomus cells, the primary site of hypoxic sensing in the carotid body, generate H2S in an O2-sensitive manner and whether endogenous H2S is required for O2 sensing by glomus cells. Experiments were performed on glomus cells harvested from anesthetized adult rats as well as age and sex-matched CSE+/+ and CSE−/− mice. Physiological levels of hypoxia (Po2 ∼30 mmHg) increased H2S levels in glomus cells, and dl-propargylglycine (PAG), a CSE inhibitor, prevented this response in a dose-dependent manner. Catecholamine (CA) secretion from glomus cells was monitored by carbon-fiber amperometry. Hypoxia increased CA secretion from rat and mouse glomus cells, and this response was markedly attenuated by PAG and in cells from CSE−/− mice. CA secretion evoked by 40 mM KCl, however, was unaffected by PAG or CSE deletion. Exogenous application of a H2S donor (50 μM NaHS) increased cytosolic Ca2+ concentration ([Ca2+]i) in glomus cells, with a time course and magnitude that are similar to that produced by hypoxia. [Ca2+]i responses to NaHS and hypoxia were markedly attenuated in the presence of Ca2+-free medium or cadmium chloride, a pan voltage-gated Ca2+ channel blocker, or nifedipine, an L-type Ca2+ channel inhibitor, suggesting that both hypoxia and H2S share common Ca2+-activating mechanisms. These results demonstrate that H2S generated by CSE is a physiologic mediator of the glomus cell's response to hypoxia.

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