scholarly journals Circadian rhythms of urinary excretion: the relationship between the amount excreted and the circadian changes.

1982 ◽  
Vol 327 (1) ◽  
pp. 39-51 ◽  
Author(s):  
D S Minors ◽  
J M Waterhouse
Keyword(s):  
Circadian Rhythms ◽  
Urinary Excretion ◽  
Circadian Changes ◽  
The Relationship

scholarly journals Changes in Plasma Tryptophan and Melatonin Content in Penned Sheep

1978 ◽  
Vol 31 (1) ◽  
pp. 49
Author(s):  
DJ Kennaway ◽  
KJ Porter ◽  
RF Seamark
Keyword(s):  
Circadian Rhythms ◽  
Plasma Levels ◽  
Blood Sampling ◽  
Night Time ◽  
Sampling Device ◽  
Blood Constituents ◽  
Circadian Changes ◽  
Plasma Tryptophan ◽  
Tryptophan Content ◽  
The Relationship

The present study was undertaken to examine the relationship between the plasma levels of melatonin and its precursor tryptophan. No circadian changes in plasma total tryptophan content were evident which could be related to the marked night-time rise in plasma melatonin. An automated programmable blood sampling device suited to studies of circadian rhythms in blood constituents is described.

The relationship between microbial N synthesis and urinary excretion of purine derivatives in Dorper×thin-tailed Han crossbred sheep

2013 ◽  
Vol 112 (1-3) ◽  
pp. 49-55 ◽  
Author(s):  
Tao Ma ◽  
Kaidong Deng ◽  
Chenggang Jiang ◽  
Yan Tu ◽  
Naifeng Zhang ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Purine Derivatives ◽  
The Relationship ◽  
Microbial N

scholarly journals Antidepressants and Circadian Rhythm: Exploring Their Bidirectional Interaction for the Treatment of Depression

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1975
Author(s):  
Soraia Silva ◽  
Joana Bicker ◽  
Amílcar Falcão ◽  
Ana Fortuna
Keyword(s):  
Circadian Rhythms ◽  
Intracellular Signaling ◽  
Scientific Evidence ◽  
Antidepressant Drugs ◽  
Positive Influence ◽  
Drug Dosing ◽  
Signaling Systems ◽  
Treatment Of Depression ◽  
Target Molecules ◽  
The Relationship

Scientific evidence that circadian rhythms affect pharmacokinetics and pharmacodynamics has highlighted the importance of drug dosing-time. Circadian oscillations alter drug absorption, distribution, metabolism, and excretion (ADME) as well as intracellular signaling systems, target molecules (e.g., receptors, transporters, and enzymes), and gene transcription. Although several antidepressant drugs are clinically available, less than 50% of depressed patients respond to first-line pharmacological treatments. Chronotherapeutic approaches to enhance the effectiveness of antidepressants are not completely known. Even so, experimental results found until this day suggest a positive influence of drug dosing-time on the efficacy of depression therapy. On the other hand, antidepressants have also demonstrated to modulate circadian rhythmicity and sleep–wake cycles. This review aims to evidence the potential of chronotherapy to improve the efficacy and/or safety of antidepressants. It includes pre-clinical and clinical studies that demonstrate the relevance of determining the most appropriate time of administration for antidepressant drugs. In parallel, their positive influence on the resynchronization of disrupted circadian rhythms is also herein discussed. It is expected that this review will promote the investigation of chronotherapy for the treatment of depression, contribute to a better understanding of the relationship between antidepressants and circadian rhythms, and consequently promote the development of new therapeutics.

Circadian Changes in Subfoveal Choroidal Thickness and the Relationship with Circulatory Factors in Healthy Subjects

2012 ◽  
Vol 53 (4) ◽  
pp. 2300 ◽  
Author(s):  
Shinichi Usui ◽  
Yasushi Ikuno ◽  
Masahiro Akiba ◽  
Ichiro Maruko ◽  
Tetsuju Sekiryu ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Choroidal Thickness ◽  
Subfoveal Choroidal Thickness ◽  
Circadian Changes ◽  
The Relationship

Circadian Rhythms in the Urinary Excretion of Metals and Organic Substances in “Healthy” Men

1983 ◽  
Vol 38 (6) ◽  
pp. 360-366 ◽  
Author(s):  
Shunichi Araki ◽  
Katsuyuki Murata ◽  
Kazuhito Yokoyama ◽  
Susumu Yanagihara ◽  
Yukiko Niinuma ◽  
...  
Keyword(s):  
Circadian Rhythms ◽  
Urinary Excretion ◽  
Organic Substances ◽  
Healthy Men

Urinary recovery of allantoin in normally fed steers

1998 ◽  
Vol 1998 ◽  
pp. 80-80
Author(s):  
F. Herrera Gomez ◽  
F. D. Deb Hovell ◽  
C. A. Sandoval Castro
Keyword(s):  
Urinary Excretion ◽  
Recovery Factor ◽  
Purine Derivatives ◽  
Urinary Recovery ◽  
Host Animal ◽  
N Supply ◽  
Normal Feeding ◽  
The Relationship ◽  
Infusion Technique ◽  
Microbial N

Studies in the use of the purine derivatives technique in ruminants have been stimulated by the possible use of this technique as an estimator of the rumen microbial-N supplied to the host animal. The recovery factor influences the estimation of the total purines absorbed and therefore the microbial-N supply. The relationship between exogenous purine input and urinary excretion and recovery has been studied using cattle maintained with the intragastric infusion technique (Orskov et al., 1979). The urinary recovery of exogenous purines has been estimated to be 0.77-0.85 (Chen et al., 1990a, Verbic et al., 1990), and this relationship has been assumed to be applicable to normal feeding situations. To our knowledge there is no data to support or reject this approach. This study examined the urinary recovery of exogenous allantoin input in steers under normal feeding conditions.

The relationship between body composition and the urinary excretion of deoxypyridinoline and galactosyl-hydroxylysine in children and adolescents

2009 ◽  
Vol 27 (6) ◽  
pp. 689-697 ◽  
Author(s):  
Oliver Fricke ◽  
Christof Land ◽  
Ralf Beccard ◽  
Oliver Semler ◽  
Angelika Stabrey ◽  
...  
Keyword(s):  
Body Composition ◽  
Urinary Excretion ◽  
Children And Adolescents ◽  
The Relationship

The Relationship between the Formation of Urea and Argininosuccinate in a Patient with Argininosuccinic Aciduria Studied with Labelled Precursors

1974 ◽  
Vol 46 (6) ◽  
pp. 715-727
Author(s):  
C. W. Crane ◽  
F. A. Jenner ◽  
R. J. Pollitt
Keyword(s):  
Oral Dose ◽  
Urinary Excretion ◽  
Time Course ◽  
Urea Cycle ◽  
Product Models ◽  
Ammonium Lactate ◽  
Argininosuccinic Aciduria ◽  
15N Urea ◽  
The Relationship

1. The time-course of urinary excretion of [15N]urea and [15N]argininosuccinate or [15N]arginine after an oral dose of [15N]ammonium lactate has been followed in patients with argininosuccinic aciduria and cystine-lysinuria respectively. The labelled argininosuccinate and arginine appeared more slowly than expected on simple precursor-product models. 2. In the patient with argininosuccinic aciduria, simultaneous ingestion of [15N]-ammonium lactate and [carbamoyl-14C]citrulline gave very different ratios of labelling with the two isotopes for urinary urea and argininosuccinate. Urinary argininosuccinate had not been in equilibrium with the urea precursor in this patient, but the plasma [14C]citrulline bore a reasonable precursor-product relationship to the urinary [14C]argininosuccinate. 3. Intravenous [guanidino-14C]arginine given to the patient with argininosuccinic aciduria resulted in a much higher degree of labelling of the plasma globulins than the albumin. This is consistent with a considerable turnover of hepatic arginine, as would be expected with a functioning Krebs-Henseleit urea cycle. 4. These results can be explained with a compartmentation model in which most of the urea is synthesized in the liver, but most of the urinary argininosuccinate is peripheral in origin.

Urinary recovery of allantoin in normally fed steers

1998 ◽  
Vol 1998 ◽  
pp. 80-80
Author(s):  
F. Herrera Gomez ◽  
F. D. Deb Hovell ◽  
C. A. Sandoval Castro
Keyword(s):  
Urinary Excretion ◽  
Recovery Factor ◽  
Purine Derivatives ◽  
Urinary Recovery ◽  
Host Animal ◽  
N Supply ◽  
Normal Feeding ◽  
The Relationship ◽  
Infusion Technique ◽  
Microbial N

Studies in the use of the purine derivatives technique in ruminants have been stimulated by the possible use of this technique as an estimator of the rumen microbial-N supplied to the host animal. The recovery factor influences the estimation of the total purines absorbed and therefore the microbial-N supply. The relationship between exogenous purine input and urinary excretion and recovery has been studied using cattle maintained with the intragastric infusion technique (Orskov et al., 1979). The urinary recovery of exogenous purines has been estimated to be 0.77-0.85 (Chen et al., 1990a, Verbic et al., 1990), and this relationship has been assumed to be applicable to normal feeding situations. To our knowledge there is no data to support or reject this approach. This study examined the urinary recovery of exogenous allantoin input in steers under normal feeding conditions.

scholarly journals Epigenetic Regulation of Circadian Rhythm and Its Possible Role in Diabetes Mellitus

2020 ◽  
Vol 21 (8) ◽  
pp. 3005 ◽  
Author(s):  
Michael Hudec ◽  
Pavlina Dankova ◽  
Roman Solc ◽  
Nardjas Bettazova ◽  
Marie Cerna
Keyword(s):  
Diabetes Mellitus ◽  
Circadian Rhythm ◽  
Circadian Rhythms ◽  
Epigenetic Regulation ◽  
External Environment ◽  
Prenatal Development ◽  
Circadian Genes ◽  
The Relationship

This review aims to summarize the knowledge about the relationship between circadian rhythms and their influence on the development of type 2 diabetes mellitus (T2DM) and metabolic syndrome. Circadian rhythms are controlled by internal molecular feedback loops that synchronize the organism with the external environment. These loops are affected by genetic and epigenetic factors. Genetic factors include polymorphisms and mutations of circadian genes. The expression of circadian genes is regulated by epigenetic mechanisms that change from prenatal development to old age. Epigenetic modifications are influenced by the external environment. Most of these modifications are affected by our own life style. Irregular circadian rhythm and low quality of sleep have been shown to increase the risk of developing T2DM and other metabolic disorders. Here, we attempt to provide a wide description of mutual relationships between epigenetic regulation, circadian rhythm, aging process and highlight new evidences that show possible therapeutic advance in the field of chrono-medicine which will be more important in the upcoming years.

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