scholarly journals Epigenetic Regulation of Circadian Rhythm and Its Possible Role in Diabetes Mellitus

2020 ◽  
Vol 21 (8) ◽  
pp. 3005 ◽  
Author(s):  
Michael Hudec ◽  
Pavlina Dankova ◽  
Roman Solc ◽  
Nardjas Bettazova ◽  
Marie Cerna
Keyword(s):  
Diabetes Mellitus ◽  
Circadian Rhythm ◽  
Circadian Rhythms ◽  
Epigenetic Regulation ◽  
External Environment ◽  
Prenatal Development ◽  
Circadian Genes ◽  
The Relationship

This review aims to summarize the knowledge about the relationship between circadian rhythms and their influence on the development of type 2 diabetes mellitus (T2DM) and metabolic syndrome. Circadian rhythms are controlled by internal molecular feedback loops that synchronize the organism with the external environment. These loops are affected by genetic and epigenetic factors. Genetic factors include polymorphisms and mutations of circadian genes. The expression of circadian genes is regulated by epigenetic mechanisms that change from prenatal development to old age. Epigenetic modifications are influenced by the external environment. Most of these modifications are affected by our own life style. Irregular circadian rhythm and low quality of sleep have been shown to increase the risk of developing T2DM and other metabolic disorders. Here, we attempt to provide a wide description of mutual relationships between epigenetic regulation, circadian rhythm, aging process and highlight new evidences that show possible therapeutic advance in the field of chrono-medicine which will be more important in the upcoming years.

The Relationship between Quality of Life, Activity and Participation among People with Type 2 Diabetes Mellitus

2018 ◽  
Vol 32 (4) ◽  
pp. 341-362 ◽  
Author(s):  
Karen E. Atler ◽  
Arlene A. Schmid ◽  
Tara C. Klinedinst ◽  
Laura A. Grimm ◽  
Tasha P. Marchant ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Life Activity ◽  
The Relationship

scholarly journals A Growing Link between Circadian Rhythms, Type 2 Diabetes Mellitus and Alzheimer’s Disease

2022 ◽  
Vol 23 (1) ◽  
pp. 504
Author(s):  
Xuemin Peng ◽  
Rongping Fan ◽  
Lei Xie ◽  
Xiaoli Shi ◽  
Kun Dong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Type 2 Diabetes ◽  
Alzheimer's Disease ◽  
Type 2 Diabetes Mellitus ◽  
Circadian Rhythm ◽  
Circadian Rhythms ◽  
Light Therapy

Type 2 diabetes mellitus (T2DM) patients are at a higher risk of developing Alzheimer’s disease (AD). Mounting evidence suggests the emerging important role of circadian rhythms in many diseases. Circadian rhythm disruption is considered to contribute to both T2DM and AD. Here, we review the relationship among circadian rhythm disruption, T2DM and AD, and suggest that the occurrence and progression of T2DM and AD may in part be associated with circadian disruption. Then, we summarize the promising therapeutic strategies targeting circadian dysfunction for T2DM and AD, including pharmacological treatment such as melatonin, orexin, and circadian molecules, as well as non-pharmacological treatments like light therapy, feeding behavior, and exercise.

scholarly journals THE RELATIONSHIP BETWEEN SELF-MANAGEMENT AND QUALITY OF LIFE AMONG PATIENTS WITH TYPE 2 DIABETES MELLITUS

2021 ◽  
Vol 10 (2) ◽  
pp. 343-349
Author(s):  
Ninik Ambar Sari ◽  
Ceria Nurhayati
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Self Management ◽  
Positive Sign ◽  
High Blood Glucose ◽  
Type 2 Dm ◽  
Spearman Test ◽  
The Relationship

Background: Diabetes Mellitus (DM) is a metabolic disease characterized by high blood glucose levels as a result of insufficient insulin secretion, impaired insulin activity or both. Patients with diabetes mellitus are at risk for complications that can affect their quality of life. These complications can be minimized through self-management.  Objectives: The aim of this study was to determine the relationship between self-management and quality of life in type 2 DM patients. Design: This study was a quantitative research. The design in this study was a cross-sectional analytic with a sample of 75 people who were carried out at the endocrine polyclinic RS Pusat TNI Angkatan Laut (RSPAL) DR. Ramelan Surabaya. Research instrument used the Diabetes Self-Management Questionnaire (DSMQ) developed by Schmitt et al (2013) to determine the self-management of type 2 DM patients and to measure the quality of life using the Diabetes Quality of Life Brief (DQoL Brief) instrument developed by Burrough et al (2008). The sample siza with simple random sampling method, and data analysis using spearman rank test. Results: The results showed that there was a significant relationship between self-management and quality of life in type 2 DM patients (p-value = .000, r = .394). Conclusion: There is a significant positive relationship between the level of self-management and quality of life in type 2 DM patients. From the results of the Spearman test correlation coefficient, there is a positive sign. This means that the higher the patient's self-management, it will also improve the quality of their life. The implication of this study are nurses can increase patient knowledge by providing education that focuses on improving self-management and facilitating the provision of family support as well as supervision and monitoring related to self-management by type 2 DM patients.

scholarly journals Hubungan Diabetes Self-Management Dengan Kualitas Hidup Pasien Diabetes Mellitus Tipe 2 di RS Amelia Pare Kediri

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Nurul Laili
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type ◽  
Self Management ◽  
Cross Sectional ◽  
Patients With Diabetes ◽  
The Relationship

Diabetes self management require compliance with complex management regimens to achieve glycemic control. Management of diabetes mellitus begins with the setting of food, physical exercise, weight control and optimal adjustment of medication. Treatment of diabetes mellitus to improve the quality of life of patients and prevent complications makrovasculer and mikrovasculer. The purpose of this research is to identify the relationship of diabetes self-management to the quality of life of patients with diabetes mellitus type 2. The design used in this study was cross sectional. The population in this study were all patients with diabetes mellitus type 2. The sample in this study are patients with diabetes mellitus type 2 who came controls on poli Amelia Pare Hospital in September 2016. The analysis performed in this study using Spearman Rank Correlation. Obtained value of Rho = 0.33 which indicates the level of relationship is. Statistical test value t = 7.23 is greater than t table = 2.457, then H₁ acceptable and it can be concluded that there is a relationship between diabetes self-management and quality of life mellitus type 2 diabetes patients with a degree of closeness of the relationship that is being nurses in providing nursing care also pay attention to the patient's needs will be perceptions about the treatment. Nurses as educators can provide explanations and correct health information about treatment and care so that quality of life can be achieved. Keyword: Diabetes Self-Management, Quality of life, Diabetes Mellitus tipe 2

scholarly journals Adiponectin, Leptin, and Chemerin in Elderly Patients with Type 2 Diabetes Mellitus: A Close Linkage with Obesity and Length of the Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Susana Coimbra ◽  
Jorge Brandão Proença ◽  
Alice Santos-Silva ◽  
Maria João Neuparth
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
The Elderly ◽  
Statistical Adjustment ◽  
The Relationship

Obesity, insulin resistance, and aging are closely associated and adipokines seem to have a crucial role in their pathophysiology. We aim to study the relationship between aging and chemerin, adiponectin, and leptin levels in type 2 diabetes mellitus (T2DM). Age correlated positively with chemerin and leptin and inversely with adiponectin. Body mass index (BMI) correlated positively with leptin (in males) and chemerin and inversely with adiponectin. The patients with ≥65 years(n=34)showed significantly higher leptin and chemerin and lower adiponectin levels than middle-aged (38–64 years) patients(n=39)and controls(n=20). After statistical adjustment for length of disease, there was a loss of significance, between T2DM groups, for adiponectin and, in female, for leptin. In the older group, BMI correlated with adiponectin and with leptin, but not with chemerin. Adiponectin and leptin levels in elderly T2DM patients seem to be closely linked to obesity and to length of the disease. In elderly T2DM patients, chemerin concentrations are increased and seem to be independent of length of disease and BMI, suggesting that adipocyte dysfunction is enhanced with aging. The understanding of the glucose homeostasis impairment in the elderly is mandatory in order to achieve ways to improve their quality of life and longevity.

scholarly journals Hubungan Depresi dengan Kualitas Hidup Pasien Diabetes Mellitus Tipe 2

2021 ◽  
Vol 2 (1) ◽  
pp. 201-208
Author(s):  
Dewi Ulfani ◽  
Safruddin Safruddin ◽  
Sudarman Sudarman ◽  
Sudarman Sudarman
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Economic Status ◽  
Sampling Technique ◽  
Cross Sectional ◽  
Significance Level ◽  
Type 2 Dm ◽  
The Relationship

Diabetes mellitus is a serious problem for global health regardless of socio-economic status or national boundaries. Diabetes mellitus is a chronic disease that cannot be completely cured and greatly affects the patient's quality of life. The incidence of DM continues to increase both in the world and in Indonesia, so far more research has been about the problem of DM clinics so that more research is needed on the quality of life. In addition, low quality of life and psychological problems can exacerbate metabolic disorders, either directly through a stress harmonic reaction or indirectly through complications. The purpose of this study was to determine the relationship between depression and quality of life of type 2 diabetes mellitus sufferers at the West Kabaena Health Center, Bombana Regency. This type of research is quantitative, with a cross sectional study design. The sample determination is done by using purposive sampling technique with a sample size of 35 respondents. The relationship test was performed using the Continuity Correction test with a significance level of α <0.05. The results showed that there was a relationship between depression and the quality of life of type 2 DM patients (p = 0.001 <0.05). The conclusion of the study is that the higher the level of individual depression, the less individual perceptions of the quality of life of type 2 DM patients. From this conclusion it is hoped that nurses will carry out health education and overcome depression in DM sufferers to improve the quality of life.

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