scholarly journals Axon-schwann cell interaction in the squid nerve fibre

1972 ◽  
Vol 225 (2) ◽  
pp. 275-296 ◽  
Author(s):  
Jorge Villegas
Keyword(s):  
Schwann Cell ◽  
Nerve Fibre ◽  
Cell Interaction

scholarly journals Control of cortical cytoskeleton-membrane interaction by RhoA regulates peripheral nerve myelination

2021 ◽  
Author(s):  
Ana I. Seixas ◽  
Miguel R. G. Morais ◽  
Cord Brakebusch ◽  
Jo&atildeo B. Relvas
Keyword(s):  
Schwann Cell ◽  
Schwann Cells ◽  
Rho Gtpases ◽  
Intracellular Signaling ◽  
Cell Interaction ◽  
Actin Dynamics ◽  
Specific Gene ◽  
Cortical Actin ◽  
Membrane Attachment ◽  
Cytoskeleton Dynamics

Bidirectional transmission of mechanical and biochemical signals is integral to cell-environment communication and underlies the function of Schwann cells, the myelinating glia of the peripheral nervous system. As major integrators of "outside-in" signaling, Rho GTPases link actin cytoskeleton dynamics with cellular architecture to regulate adhesion and cell deformation. Using Schwann cell-specific gene inactivation, we discovered that RhoA promotes the initiation of myelination, axonal wrapping and axial spreading of Schwann cells, and is later required to restrict myelin growth in peripheral nerves. These effects are mediated by modulation of actomyosin contractility, actin dynamics and cortical actin-membrane attachment, which collectively couple tensional forces to intracellular signaling that regulate axon-Schwann cell interaction and myelin synthesis. This work establishes RhoA as an intrinsic regulator of a biomechanical response that controls the switch of Schwann cells towards the myelinating and the homeostatic states.

Substance P modulation of the membrane potential of the Schwann cell of the squid giant nerve fibre

Glia ◽  
1990 ◽  
Vol 3 (5) ◽  
pp. 393-404 ◽  
Author(s):  
Peter D. Evans ◽  
Vincenzina Reale ◽  
Rosa Maria Merzon ◽  
Jorge Villegas
Keyword(s):  
Membrane Potential ◽  
Substance P ◽  
Schwann Cell ◽  
Nerve Fibre

scholarly journals Octopaminergic modulation of the membrane potential of the Schwann cell of the squid giant nerve fibre

1986 ◽  
Vol 121 (1) ◽  
pp. 421-443 ◽  
Author(s):  
V. Reale ◽  
P. D. Evans ◽  
J. Villegas
Keyword(s):  
Schwann Cell ◽  
Schwann Cells ◽  
Nerve Fibre ◽  
High Frequency ◽  
Cell Activity ◽  
Physiological Role ◽  
Giant Axon ◽  
Octopamine Receptors ◽  
Low Concentrations

The actions of octopamine on the Schwann cells of the giant nerve fibre of the tropical squid are described. The pharmacology of the receptors mediating the actions of octopamine has been investigated in terms of stereospecificity, amine specificity and interactions with a range of agonists and antagonists. The receptors are maximally activated by D(−)-octopamine and share many of the characteristics of OCTOPAMINE2 class receptors in other preparations. The octopamine receptors appear to mediate their actions by increasing the intracellular levels of cyclic AMP in the Schwann cells. Low concentrations of octopamine potentiate the actions of the nicotinic cholinergic activation system of the Schwann cells. The results are discussed in terms of the possible physiological role of octopamine in the modulation of Schwann cell activity during stressful conditions when the giant axon system is likely to be used at a high frequency to facilitate the escape response of the squid.

scholarly journals N-cadherin-Presented Slit Repulsive-Cues Direct Collective Schwann cell Migration

2019 ◽  
Author(s):  
Julian J.A Hoving ◽  
Elizabeth Harford-Wright ◽  
Patrick Wingfield-Digby ◽  
Anne-Laure Cattin ◽  
Mariana Campana ◽  
...  
Keyword(s):  
Cell Migration ◽  
Schwann Cell ◽  
Peripheral Nerve Regeneration ◽  
Adherens Junction ◽  
Cell Interaction ◽  
Collective Cell Migration ◽  
Cancer Migration ◽  
Cell Collective ◽  
Migratory Cell ◽  
Cell Cell

AbstractCollective cell migration is fundamental for the development of organisms and in the adult, for tissue regeneration and in pathological conditions such as cancer. Migration as a coherent group requires the maintenance of cell-cell interactions, while contact-inhibition-of-locomotion (CIL), a local repulsive force, propels the group forward. Here we show that the cell-cell interaction molecule, N-cadherin, regulates both adhesion and repulsion processes during Schwann cell collective migration, which is required for peripheral nerve regeneration. However, distinct from its role in cell-cell adhesion, the repulsion process is independent of N-cadherin trans-homodimerisation and the associated adherens junction complex. Rather, the extracellular domain of N-cadherin acts to traffic a repulsive Slit2/Slit3 signal to the cell-surface. Inhibiting Slit2/Slit3 signalling inhibits CIL and subsequently collective SC migration, resulting in adherent, non-migratory cell clusters. These findings provide insight into how opposing signals can mediate collective cell migration and how CIL pathways are promising targets for inhibiting pathological cell migration.

Neuron-schwann cell interaction in basal lamina formation

1982 ◽  
Vol 92 (2) ◽  
pp. 449-460 ◽  
Author(s):  
Mary Bartlett Bunge ◽  
Ann K. Williams ◽  
Patrick M. Wood
Keyword(s):  
Schwann Cell ◽  
Basal Lamina ◽  
Cell Interaction

scholarly journals N-methyl-D-aspartate (NMDA) and non-NMDA (metabotropic) type glutamate receptors modulate the membrane potential of the Schwann cell of the squid giant nerve fibre.

1992 ◽  
Vol 173 (1) ◽  
pp. 229-249 ◽  
Author(s):  
P D Evans ◽  
V Reale ◽  
R M Merzon ◽  
J Villegas
Keyword(s):  
Amino Acids ◽  
Membrane Potential ◽  
Schwann Cell ◽  
Glutamate Receptors ◽  
Nerve Fibre ◽  
Excitatory Amino Acids ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate ◽  
Type Receptor ◽  
Lasting Change

L-Glutamate application can produce three different responses in the membrane potential of the Schwann cell of the tropical squid, Sepioteuthis sepioidea, which appear to be mediated by three pharmacologically distinct classes of receptor. A class of non-NMDA-type receptors, with some similarities to metabotropic glutamate receptors, mediates the development of a rapid and long-lasting hyperpolarization. Two pharmacologically distinct classes of NMDA-type receptor are present. One mediates the development of a slow depolarization accompanied by a long-lasting change in responsiveness of the Schwann cell. The second produces rapid depolarizing responses during the period of this changed responsiveness. All three types of receptor can be activated by dipeptides containing excitatory amino acids.

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