Global Reach 2018: The adaptive phenotype to life with chronic mountain sickness and polycythaemia

2021 ◽  
Author(s):  
Alexander B. Hansen ◽  
Gilbert Moralez ◽  
Sachin B. Amin ◽  
Lydia L. Simspon ◽  
Florian Hofstaetter ◽  
...  
Keyword(s):  
Chronic Mountain Sickness ◽  
Mountain Sickness ◽  
Global Reach

scholarly journals Global REACH 2018: Andean highlanders, chronic mountain sickness and the integrative regulation of resting blood pressure

2020 ◽  
Vol 106 (1) ◽  
pp. 104-116 ◽  
Author(s):  
Lydia L. Simpson ◽  
Victoria L. Meah ◽  
Andrew R. Steele ◽  
Christopher Gasho ◽  
Connor A. Howe ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Mountain Sickness ◽  
Resting Blood Pressure ◽  
Mountain Sickness ◽  
Global Reach

Global REACH 2018: Volume regulation in high-altitude Andeans with and without chronic mountain sickness

2021 ◽  
Author(s):  
Andrew R. Steele ◽  
Michael M. Tymko ◽  
Victoria L. Meah ◽  
Lydia L Simpson ◽  
Christopher Gasho ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Plasma Renin Activity ◽  
High Altitude ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Plasma Renin ◽  
Renin Activity ◽  
Chronic Mountain Sickness ◽  
Plasma Aldosterone Concentration ◽  
Mountain Sickness

The high-altitude maladaptation syndrome known as chronic mountain sickness (CMS) is characterized by polycythemia and is associated with proteinuria despite unaltered glomerular filtration rate. However, it remains unclear if indigenous highlanders with CMS have altered volume regulatory hormones. We assessed N-terminal pro-B-type natriuretic peptide (NT pro-BNP), plasma aldosterone concentration, plasma renin activity, kidney function (urinary microalbumin, glomerular filtration rate), blood volume, and estimated pulmonary artery systolic pressure (ePASP), in Andean males without (n=14; age=39±11) and with (n=10; age=40±12) CMS at 4330 meters (Cerro de Pasco, Peru). Plasma renin activity (non-CMS: 15.8±7.9 vs. CMS: 8.7±5.4 ng/ml; p=0.025) and plasma aldosterone concentration (non-CMS: 77.5±35.5 vs. CMS: 54.2±28.9 pg/ml; p=0.018) were lower in highlanders with CMS compared to non-CMS, while NT pro-BNP was not different between groups (non-CMS: 1394.9±214.3 vs. CMS: 1451.1±327.8 pg/ml; p=0.15). Highlanders had similar total blood volume (non-CMS: 90±15 vs. CMS: 103±18 ml • kg-1; p=0.071), but Andeans with CMS had greater total red blood cell volume (non-CMS: 46±10 vs. CMS 66±14 ml • kg-1; p<0.01) and smaller plasma volume (non-CMS 43±7 vs. CMS 35±5 ml • kg-1; p=0.03) compared to non-CMS. There were no differences in ePASP between groups (non-CMS 32±9 vs. CMS 31±8 mmHg; p=0.6). A negative correlation was found between plasma renin activity and glomerular filtration rate in both groups (group: r=-0.66; p<0.01; non-CMS: r=-0.60; p=0.022; CMS: r=-0.63; p=0.049). A smaller plasma volume in Andeans with CMS may indicate an additional CMS maladaptation to high-altitude, causing potentially greater polycythemia and clinical symptoms.

International Working Group For Chronic Mountain Sickness

2001 ◽  
pp. 439-440 ◽  
Author(s):  
Ingrid Asmussen ◽  
Luciano Bernardi ◽  
Peter Bärtsch ◽  
Tom Hornbein ◽  
Fabiola Leon-Velarde ◽  
...  
Keyword(s):  
Working Group ◽  
Chronic Mountain Sickness ◽  
International Working Group ◽  
Mountain Sickness

Increased hypoxic proliferative response in PBMCs‐derived erythroid progenitor cells of Andean highlanders with Chronic Mountain Sickness

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Daniela Bermudez ◽  
Cecilia Anza‐Ramirez ◽  
Miguel Ángel Orrego‐Solano ◽  
Cristina Guerra‐Giraldez ◽  
Francisco C. Villafuerte
Keyword(s):  
Progenitor Cells ◽  
Proliferative Response ◽  
Erythroid Progenitor ◽  
Chronic Mountain Sickness ◽  
Erythroid Progenitor Cells ◽  
Mountain Sickness

scholarly journals Whole-Genome Sequencing Uncovers the Genetic Basis of Chronic Mountain Sickness in Andean Highlanders

2013 ◽  
Vol 93 (3) ◽  
pp. 452-462 ◽  
Author(s):  
Dan Zhou ◽  
Nitin Udpa ◽  
Roy Ronen ◽  
Tsering Stobdan ◽  
Junbin Liang ◽  
...  
Keyword(s):  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Genetic Basis ◽  
Whole Genome ◽  
Chronic Mountain Sickness ◽  
Mountain Sickness
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