scholarly journals Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnoea?

2007 ◽  
Vol 92 (1) ◽  
pp. 27-37 ◽  
Author(s):  
Safraaz Mahamed ◽  
Gordon S. Mitchell
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Intermittent Hypoxia ◽  
Sleep Apnoea ◽  
Obstructive Sleep ◽  
Respiratory Plasticity

scholarly journals Metabolomics and microbiome profiling as biomarkers in obstructive sleep apnoea: a comprehensive review

2021 ◽  
Vol 30 (160) ◽  
pp. 200220
Author(s):  
Xiaoman Zhang ◽  
Shengming Wang ◽  
Huajun Xu ◽  
Hongliang Yi ◽  
Jian Guan ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Intermittent Hypoxia ◽  
Sleep Disordered Breathing ◽  
Acid Metabolism ◽  
Cardiovascular Complications ◽  
Sleep Apnoea ◽  
Obstructive Sleep ◽  
Integral Role ◽  
Microbiome Profiling ◽  
Shed Light

IntroductionObstructive sleep apnoea (OSA) is a common sleep disorder with a high social and economic burden. Thus, early prediction and diagnosis of OSA are important. Changes in metabolism and the microbiome may serve as biomarkers for OSA. Herein, we review the literature on the metabolomic and microbiome changes associated with OSA, and identify the metabolites and microorganisms involved.MethodsWe searched the PUBMED and EMBASE electronic databases using the following terms: “obstructive sleep apnea”, “OSA”, “sleep disordered breathing”, “SDB”, “intermittent hypoxia”, “sleep fragmentation”, and either “metabolomics” or “microbiome”. In total, 273 papers were identified, of which 28 were included in our study.ResultsChanges in the levels of certain metabolites related to fatty acid, carbohydrate and amino acid metabolism were associated with the incidence of OSA. The diversity and abundance of microflora, particularly Firmicutes and Bacteroidetes, were altered in humans and rodents with OSA.ConclusionsCertain changes in metabolism and the microbiota play an integral role in the pathophysiology of OSA and OSA-induced cardiovascular complications. Metabolomic and microbiome biomarkers shed light on the pathogenesis of OSA, and facilitate early diagnosis and treatment.

scholarly journals Human intermittent hypoxia-induced respiratory plasticity is not caused by inflammation

2015 ◽  
Vol 46 (4) ◽  
pp. 1072-1083 ◽  
Author(s):  
Andrew E. Beaudin ◽  
Xavier Waltz ◽  
Matiram Pun ◽  
Katherine E. Wynne-Edwards ◽  
Sofia B. Ahmed ◽  
...  
Keyword(s):  
Intermittent Hypoxia ◽  
Sleep Apnoea ◽  
Double Blind ◽  
Healthy Humans ◽  
Cox Inhibitor ◽  
Obstructive Sleep ◽  
Tnf Α ◽  
Respiratory Plasticity ◽  
Cox 2

Ventilatory instability, reflected by enhanced acute hypoxic (AHVR) and hypercapnic (AHCVR) ventilatory responses is a fundamental component of obstructive sleep apnoea (OSA) pathogenesis. Intermittent hypoxia-induced inflammation is postulated to promote AHVR enhancement in OSA, although the role of inflammation in intermittent hypoxia-induced respiratory changes in humans has not been examined. Thus, this study assessed the role of inflammation in intermittent hypoxia-induced respiratory plasticity in healthy humans.In a double-blind, placebo-controlled, randomised crossover study design, 12 males were exposed to 6 h of intermittent hypoxia on three occasions. Prior to intermittent hypoxia exposures, participants ingested (for 4  days) either placebo or the nonsteroidal anti-inflammatory drugs indomethacin (nonselective cyclooxygenase (COX) inhibitor) and celecoxib (selective COX-2 inhibitor). Pre- and post-intermittent hypoxia resting ventilation, AHVR, AHCVR and serum concentration of the pro-inflammatory cytokine tumour necrosis factor (TNF)-α were assessed.Pre-intermittent hypoxia resting ventilation, AHVR, AHCVR and TNF-α concentrations were similar across all three conditions (p≥0.093). Intermittent hypoxia increased resting ventilation and the AHVR similarly across all conditions (p=0.827), while the AHCVR was increased (p=0.003) and TNF-α was decreased (p=0.006) with only selective COX-2 inhibition.These findings indicate that inflammation does not contribute to human intermittent hypoxia-induced respiratory plasticity. Moreover, selective COX-2 inhibition augmented the AHCVR following intermittent hypoxia exposure, suggesting that selective COX-2 inhibition could exacerbate OSA severity by increasing ventilatory instability.

scholarly journals Impact of obstructive sleep apnoea and intermittent hypoxia on cardiovascular and cerebrovascular regulation

2017 ◽  
Vol 102 (7) ◽  
pp. 743-763 ◽  
Author(s):  
Andrew E. Beaudin ◽  
Xavier Waltz ◽  
Patrick J. Hanly ◽  
Marc J. Poulin
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Intermittent Hypoxia ◽  
Sleep Apnoea ◽  
Obstructive Sleep ◽  
Cerebrovascular Regulation
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