Mechanisms of intermittent hypoxia‐mediated macrophage activation – potential therapeutic targets for obstructive sleep apnoea

2020 ◽  
Author(s):  
Susan F. Fitzpatrick ◽  
Ailbhe D. King ◽  
Cliona O’Donnell ◽  
Helen M. Roche ◽  
Silke Ryan
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Intermittent Hypoxia ◽  
Macrophage Activation ◽  
Therapeutic Targets ◽  
Sleep Apnoea ◽  
Obstructive Sleep ◽  
Activation Potential

scholarly journals Metabolomics and microbiome profiling as biomarkers in obstructive sleep apnoea: a comprehensive review

2021 ◽  
Vol 30 (160) ◽  
pp. 200220
Author(s):  
Xiaoman Zhang ◽  
Shengming Wang ◽  
Huajun Xu ◽  
Hongliang Yi ◽  
Jian Guan ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Intermittent Hypoxia ◽  
Sleep Disordered Breathing ◽  
Acid Metabolism ◽  
Cardiovascular Complications ◽  
Sleep Apnoea ◽  
Obstructive Sleep ◽  
Integral Role ◽  
Microbiome Profiling ◽  
Shed Light

IntroductionObstructive sleep apnoea (OSA) is a common sleep disorder with a high social and economic burden. Thus, early prediction and diagnosis of OSA are important. Changes in metabolism and the microbiome may serve as biomarkers for OSA. Herein, we review the literature on the metabolomic and microbiome changes associated with OSA, and identify the metabolites and microorganisms involved.MethodsWe searched the PUBMED and EMBASE electronic databases using the following terms: “obstructive sleep apnea”, “OSA”, “sleep disordered breathing”, “SDB”, “intermittent hypoxia”, “sleep fragmentation”, and either “metabolomics” or “microbiome”. In total, 273 papers were identified, of which 28 were included in our study.ResultsChanges in the levels of certain metabolites related to fatty acid, carbohydrate and amino acid metabolism were associated with the incidence of OSA. The diversity and abundance of microflora, particularly Firmicutes and Bacteroidetes, were altered in humans and rodents with OSA.ConclusionsCertain changes in metabolism and the microbiota play an integral role in the pathophysiology of OSA and OSA-induced cardiovascular complications. Metabolomic and microbiome biomarkers shed light on the pathogenesis of OSA, and facilitate early diagnosis and treatment.

scholarly journals Impact of obstructive sleep apnoea and intermittent hypoxia on cardiovascular and cerebrovascular regulation

2017 ◽  
Vol 102 (7) ◽  
pp. 743-763 ◽  
Author(s):  
Andrew E. Beaudin ◽  
Xavier Waltz ◽  
Patrick J. Hanly ◽  
Marc J. Poulin
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Intermittent Hypoxia ◽  
Sleep Apnoea ◽  
Obstructive Sleep ◽  
Cerebrovascular Regulation
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