scholarly journals Exposure to mild intermittent hypoxia increases loop gain and the arousal threshold in participants with obstructive sleep apnoea

2019 ◽  
Vol 597 (14) ◽  
pp. 3507-3508
Author(s):  
Naomi L. Deacon‐Diaz
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Intermittent Hypoxia ◽  
Sleep Apnoea ◽  
Loop Gain ◽  
Arousal Threshold ◽  
Obstructive Sleep

scholarly journals Exposure to mild intermittent hypoxia increases loop gain and the arousal threshold in participants with obstructive sleep apnoea

2019 ◽  
Vol 597 (14) ◽  
pp. 3697-3711 ◽  
Author(s):  
Raichel M. Alex ◽  
Gino S. Panza ◽  
Huzaifa Hakim ◽  
M. Safwan Badr ◽  
Bradley A. Edwards ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Intermittent Hypoxia ◽  
Sleep Apnoea ◽  
Loop Gain ◽  
Arousal Threshold ◽  
Obstructive Sleep

scholarly journals P019 Obstructive sleep apnoea endotypes in people with multiple sclerosis

2021 ◽  
Vol 2 (Supplement_1) ◽  
pp. A27-A28
Author(s):  
S Carter ◽  
H Hensen ◽  
A Krishnan ◽  
A Chiang ◽  
J Carberry ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Obstructive Sleep Apnoea ◽  
Group Analysis ◽  
Respiratory Control ◽  
Upper Airway ◽  
Sleep Apnoea ◽  
Loop Gain ◽  
Male Predominance ◽  
Arousal Threshold ◽  
Obstructive Sleep

Abstract Purpose Obstructive sleep apnoea (OSA) is common in people with multiple sclerosis (MS) despite a lack of typical risk factors for OSA in people with MS such as obesity and male predominance. Therefore, underlying factors other than sex and obesity may be particularly important in the pathogenesis of OSA in people with MS. Thus, the primary aim of this study was to determine the relative contributions of OSA endotypes in people with MS and compare this to matched controls with OSA only. Methods Eleven people with MS and OSA (MS-OSA group) (apnoea-hypopnoea index [AHI]>5events/h) and eleven controls matched for OSA severity, age and sex without MS (OSA group) were studied. Participants underwent a detailed overnight polysomnography with an epiglottic pressure catheter and genioglossus intramuscular electrodes to allow for quantification of pathophysiological contributors to OSA. This included the respiratory arousal threshold, genioglossus muscle responsiveness, respiratory loop gain and upper airway collapsibility. Results Measures of the four primary OSA endotypes were not different between the MS-OSA and OSA groups (e.g. NREM respiratory arousal threshold -27±15 vs. -23±8 cmH2O respectively, p=0.24). Within group analysis indicated higher loop gain in non-obese MS-OSA participants compared to obese MS-OSA participants (0.53±0.11 vs. 0.37±0.11, p=0.04). Conclusions Overall, OSA endotypes are similar between MS-OSA participants and matched OSA controls. However, within the MS-OSA group, non-obese participants have higher loop gain (unstable respiratory control) compared to obese participants. Thus, unstable respiratory control may play an important role in OSA pathogenesis in many people with MS.

scholarly journals Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea

2012 ◽  
Vol 590 (5) ◽  
pp. 1199-1211 ◽  
Author(s):  
Bradley A. Edwards ◽  
Scott A. Sands ◽  
Danny J. Eckert ◽  
David P. White ◽  
James P. Butler ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
The Other ◽  
Physiological Traits ◽  
Loop Gain ◽  
Obstructive Sleep

scholarly journals Integrating loop gain into the understanding of obstructive sleep apnoea mechanisms

2018 ◽  
Vol 596 (17) ◽  
pp. 3819-3820 ◽  
Author(s):  
Luu V. Pham ◽  
Alan R. Schwartz ◽  
Vsevolod Y. Polotsky
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Loop Gain ◽  
Obstructive Sleep

scholarly journals Dynamic loop gain increases upon adopting the supine body position during sleep in patients with obstructive sleep apnoea

Respirology ◽  
2017 ◽  
Vol 22 (8) ◽  
pp. 1662-1669 ◽  
Author(s):  
Simon A. Joosten ◽  
Shane A. Landry ◽  
Scott A. Sands ◽  
Philip I. Terrill ◽  
Dwayne Mann ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Body Position ◽  
Sleep Apnoea ◽  
Loop Gain ◽  
Obstructive Sleep
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