scholarly journals Dysregulated mitochondrial Ca2+ and ROS signaling in skeletal muscle of ALS mouse model

2019 ◽  
Vol 663 ◽  
pp. 249-258 ◽  
Author(s):  
Jingsong Zhou ◽  
Ang Li ◽  
Xuejun Li ◽  
Jianxun Yi
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Ros Signaling

scholarly journals Nuclear defects in skeletal muscle from a Dynamin 2-linked centronuclear myopathy mouse model

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Anaïs Fongy ◽  
Sestina Falcone ◽  
Jeanne Lainé ◽  
Bernard Prudhon ◽  
Aurea Martins-Bach ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Centronuclear Myopathy ◽  
Dynamin 2

scholarly journals Cerebral and skeletal muscle feed artery vasoconstrictor responses in a mouse model with greater large elastic artery stiffness

2019 ◽  
Vol 104 (3) ◽  
pp. 434-442 ◽  
Author(s):  
Ashley E. Walker ◽  
Elise K. Kronquist ◽  
Kerrick T. Chinen ◽  
Kelly D. Reihl ◽  
Dean Y. Li ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Artery Stiffness ◽  
Elastic Artery

scholarly journals A Skeletal Muscle Conditional KCNJ2 Knock-Out Mouse Model for Periodic Paralysis in Andersen-Tawil Syndrome

2019 ◽  
Vol 116 (3) ◽  
pp. 242a
Author(s):  
Nathaniel Elia ◽  
Ekaterina Mokhonova ◽  
Marbella Quinonez ◽  
Stephen Cannon
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Periodic Paralysis ◽  
Knock Out ◽  
Knock Out Mouse

scholarly journals Greater impairments in cerebral artery compared with skeletal muscle feed artery endothelial function in a mouse model of increased large artery stiffness

2015 ◽  
Vol 593 (8) ◽  
pp. 1931-1943 ◽  
Author(s):  
Ashley E. Walker ◽  
Grant D. Henson ◽  
Kelly D. Reihl ◽  
R. Garrett Morgan ◽  
Parker S. Dobson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Endothelial Function ◽  
Cerebral Artery ◽  
Large Artery ◽  
Artery Stiffness

scholarly journals ROS-related mitochondrial dysfunction in skeletal muscle of an ALS mouse model during the disease progression

2018 ◽  
Vol 138 ◽  
pp. 25-36 ◽  
Author(s):  
Yajuan Xiao ◽  
Chehade Karam ◽  
Jianxun Yi ◽  
Lin Zhang ◽  
Xuejun Li ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Mitochondrial Dysfunction ◽  
Disease Progression

scholarly journals Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Minchul Kim ◽  
Vedran Franke ◽  
Bettina Brandt ◽  
Elijah D. Lowenstein ◽  
Verena Schöwel ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Fiber Type ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Isolated Nuclei ◽  
Nuclear Compartments ◽  
Transcriptional Dynamics ◽  
Single Nucleus ◽  
Functional Analyses

AbstractSyncytial skeletal muscle cells contain hundreds of nuclei in a shared cytoplasm. We investigated nuclear heterogeneity and transcriptional dynamics in the uninjured and regenerating muscle using single-nucleus RNA-sequencing (snRNAseq) of isolated nuclei from muscle fibers. This revealed distinct nuclear subtypes unrelated to fiber type diversity, previously unknown subtypes as well as the expected ones at the neuromuscular and myotendinous junctions. In fibers of the Mdx dystrophy mouse model, distinct subtypes emerged, among them nuclei expressing a repair signature that were also abundant in the muscle of dystrophy patients, and a nuclear population associated with necrotic fibers. Finally, modifications of our approach revealed the compartmentalization in the rare and specialized muscle spindle. Our data identifies nuclear compartments of the myofiber and defines a molecular roadmap for their functional analyses; the data can be freely explored on the MyoExplorer server (https://shiny.mdc-berlin.de/MyoExplorer/).

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