Mathematical Modeling Of An Amperometric Glucose Sensor: The Effect Of Membrane Permeability And Selectivity On Performance

2012 ◽  
Author(s):  
Azila Abd. Aziz
Keyword(s):  
Mathematical Modeling ◽  
Transport Properties ◽  
Membrane Permeability ◽  
Glucose Sensor ◽  
Digital Simulation ◽  
Glucose Biosensor ◽  
Glucose Biosensors ◽  
Interference Reduction ◽  
Membrane Selectivity ◽  
Selective Membrane

Gangguan dari bahan kimia elektro–aktif seperti asid askorbik, asid urik dan asetaminofen adalah merupakan satu masalah bagi biosensor glukosa berasaskan peroksid. Kebanyakan kerja penyelidikan memfokuskan kepada penggunaan membran yang perm–selektif di antara elektrod dan komponen aktif sensor untuk menghilangkan masalah ini. Dalam kerja penyelidikan ini, satu model matematik telah dibina untuk mengkaji kesan kebolehtelapan dan kememilihan bagi prestasi biosensor glukosa berasaskan peroksid. Simulasi digital telah dijalankan menggunakan kaedah pembezaan terhingga. Seperti yang dijangka, kememilihan membran kepada peroksid memainkan peranan besar dalam mengurangkan gangguan. Namun begitu, model juga mencadangkan yang manipulasi sifat pengangkutan lapisan pelindung luar boleh juga menghasilkan keputusan yang memberangsangkan dalam mengurangkan gangguan. Kata kunci: Biosensor glukosa; model matematik; asetaminofen; pengganggu; sifat pengangkutan Interference from electro–active chemicals such as ascorbic acid, uric acid and acetaminophen can be a problem for peroxide based glucose biosensors. Most works focused on the employment of a perm–selective membrane sandwiched between the electrode and the active component of the sensor to overcome this problem. In this work, a mathematical model has been developed to study the effect of membrane permeability and selectivity on peroxide based glucose biosensor performance. Digital simulation was carried out using the finite difference method. As expected, membrane selectivity to peroxide played a major role in interference reduction. However, interestingly, the model also suggested that the manipulation of the transport properties of the protective outer layer would also result in acceptable interference reduction. Key words: Glucose biosensors; mathematical modeling; acetaminophen; interferents; transport properties

scholarly journals Biosensing Membrane Base on Ferulic Acid and Glucose Oxidase for an Amperometric Glucose Biosensor

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3757
Author(s):  
Gabriela Valdés-Ramírez ◽  
Laura Galicia
Keyword(s):  
Ferulic Acid ◽  
Glucose Oxidase ◽  
Aqueous Media ◽  
Glucose Biosensor ◽  
Single Step ◽  
Coefficient Of Determination ◽  
The Novel ◽  
Carbon Paste ◽  
Glucose Response ◽  
Glucose Biosensors

A biosensing membrane base on ferulic acid and glucose oxidase is synthesized onto a carbon paste electrode by electropolymerization via cyclic voltammetry in aqueous media at neutral pH at a single step. The developed biosensors exhibit a linear response from 0.082 to 34 mM glucose concentration, with a coefficient of determination R2 equal to 0.997. The biosensors display a sensitivity of 1.1 μAmM−1 cm−2, a detection limit of 0.025 mM, and 0.082 mM as glucose quantification limit. The studies reveal stable, repeatable, and reproducible biosensors response. The results indicate that the novel poly-ferulic acid membrane synthesized by electropolymerization is a promising method for glucose oxidase immobilization towards the development of glucose biosensors. The developed glucose biosensors exhibit a broader linear glucose response than other polymer-based glucose biosensors.

scholarly journals A Facile Fabrication of a Potentiometric Arrayed Glucose Biosensor Based on Nafion-GOx/GO/AZO

Sensors ◽  
2020 ◽  
Vol 20 (4) ◽  
pp. 964
Author(s):  
Jung-Chuan Chou ◽  
Si-Hong Lin ◽  
Tsu-Yang Lai ◽  
Po-Yu Kuo ◽  
Chih-Hsien Lai ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Electrochemical Impedance ◽  
Limit Of Detection ◽  
Low Cost ◽  
Glucose Biosensor ◽  
Average Sensitivity ◽  
Glucose Biosensors ◽  
Coating Method ◽  
Aluminum Doped Zinc Oxide ◽  
Screen Printing Technology

In this study, the potentiometric arrayed glucose biosensors, which were based on zinc oxide (ZnO) or aluminum-doped zinc oxide (AZO) sensing membranes, were fabricated by using screen-printing technology and a sputtering system, and graphene oxide (GO) and Nafion-glucose oxidase (GOx) were used to modify sensing membranes by using the drop-coating method. Next, the material properties were characterized by using a Raman spectrometer, a field-emission scanning electron microscope (FE-SEM), and a scanning probe microscope (SPM). The sensing characteristics of the glucose biosensors were measured by using the voltage–time (V-T) measurement system. Finally, electrochemical impedance spectroscopy (EIS) was conducted to analyze their charge transfer abilities. The results indicated that the average sensitivity of the glucose biosensor based on Nafion-GOx/GO/AZO was apparently higher than that of the glucose biosensor based on Nafion-GOx/GO/ZnO. In addition, the glucose biosensor based on Nafion-GOx/GO/AZO exhibited an excellent average sensitivity of 15.44 mV/mM and linearity of 0.997 over a narrow range of glucose concentration range, a response time of 26 s, a limit of detection (LOD) of 1.89 mM, and good reproducibility. In terms of the reversibility and stability, the hysteresis voltages (VH) were 3.96 mV and 2.42 mV. Additionally, the glucose biosensor also showed good anti-inference ability and reproducibility. According to these results, it is demonstrated that AZO is a promising material, which could be used to develop a reliable, simple, and low-cost potentiometric glucose biosensor.

Encapsulation studies and selective membrane permeability properties of self-assembly hollow nanospheres

Soft Matter ◽  
2011 ◽  
Vol 7 (3) ◽  
pp. 1018-1024 ◽  
Author(s):  
Wei Ha ◽  
Xian-Wei Meng ◽  
Quan Li ◽  
Min-Min Fan ◽  
Shu-Lin Peng ◽  
...  
Keyword(s):  
Membrane Permeability ◽  
Self Assembly ◽  
Hollow Nanospheres ◽  
Selective Membrane

scholarly journals Polymersome Membrane Permeability and Ionic Transport Properties in the Presence of Sub-2nm Carbon Nanotube Porins

2016 ◽  
Vol 110 (3) ◽  
pp. 338a-339a
Author(s):  
Jeremy Sanborn ◽  
Ramya Tunuguntla ◽  
Atul Parikh ◽  
Aleksandr Noy
Keyword(s):  
Carbon Nanotube ◽  
Transport Properties ◽  
Membrane Permeability ◽  
Ionic Transport

Enhancement of glucose oxide electron-transfer mechanism in glucose biosensor via optimum physical chemistry of functionalized carbon nanotubes

2017 ◽  
Vol 33 (2) ◽  
Author(s):  
Amin TermehYousefi ◽  
Hirofumi Tanaka ◽  
Samira Bagheri
Keyword(s):  
Carbon Nanotubes ◽  
Electron Transfer ◽  
Carbon Nanostructures ◽  
Growth Control ◽  
Chemical Vapor ◽  
Glucose Biosensor ◽  
Transfer Mechanism ◽  
Modern Approach ◽  
Electron Transfer Mechanism ◽  
Glucose Biosensors

AbstractNanostructures are a viable candidate for the construction of simple blood sugar monitoring devices. Electrochemical oxidation based on the immobilization of glucose oxidase (GOx) on carbon nanostructures has paved the way for a modern approach to the determination of glucose levels in blood. Carbon nanotubes (CNTs) exhibit excellent electrical properties, resulting in increased interest in glucose biosensors based on CNTs. Its large surface area and optimum aspect ratio increase the total amount of immobilized biomaterials onto its surface. In this contribution, recent advances in the development of reliable methods to improve the electron-transfer mechanism of GOx in CNT-based glucose biosensors are highlighted. Moreover, mass production and growth mechanism of purified CNTs by chemical vapor deposition were discussed by emphasizing its growth-control aspects.

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