New data about home range and movements of Oligoryzomys flavescens (Rodentia: Cricetidae) help to understand the spread and transmission of Andes virus that causes Hantavirus Pulmonary Syndrome

2020 ◽  
Vol 67 (3) ◽  
pp. 308-317
Author(s):  
Malena Maroli ◽  
Belén Crosignani ◽  
Carlos I. Piña ◽  
Rocío Coelho ◽  
Valeria P. Martínez ◽  
...  
Keyword(s):  
Home Range ◽  
Hantavirus Pulmonary Syndrome ◽  
Andes Virus ◽  
Oligoryzomys Flavescens

scholarly journals 1471. Case Report: Andes Virus Hantavirus Pulmonary Syndrome in a Traveler Returning to the United States

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S455-S455
Author(s):  
David Bergamo ◽  
Alfred Bacon ◽  
David Cohen ◽  
Paula Eggers ◽  
Aaron Kofman ◽  
...  
Keyword(s):  
United States ◽  
Case Report ◽  
The United States ◽  
Hantavirus Pulmonary Syndrome ◽  
Andes Virus

scholarly journals Active and Passive Vaccination against Hantavirus Pulmonary Syndrome with Andes Virus M Genome Segment-Based DNA Vaccine

2003 ◽  
Vol 77 (18) ◽  
pp. 9894-9905 ◽  
Author(s):  
D. M. Custer ◽  
E. Thompson ◽  
C. S. Schmaljohn ◽  
T. G. Ksiazek ◽  
J. W. Hooper
Keyword(s):  
Neutralizing Antibodies ◽  
Rhesus Macaques ◽  
Case Fatality ◽  
Viral Disease ◽  
Genome Segment ◽  
Hantavirus Pulmonary Syndrome ◽  
South American ◽  
Andes Virus ◽  
Passive Vaccination ◽  
M Genome

ABSTRACT Hantavirus pulmonary syndrome (HPS) is a rapidly progressing human disease with one of the highest case fatality rates (30 to 50%) of any acute viral disease known. There are no vaccines, effective antiviral drugs, or immunologics to prevent or treat HPS. In an attempt to develop HPS medical countermeasures, we constructed an expression plasmid, pWRG/AND-M, that contains the full-length M genome segment of Andes virus (ANDV), a South American hantavirus. Transfection experiments in cell culture indicated that both the G1 and G2 glycoproteins are expressed from pWRG/AND-M. Rhesus macaques vaccinated by gene gun with pWRG/AND-M developed remarkably high levels of neutralizing antibodies that not only neutralized ANDV but also cross-neutralized other HPS-associated hantaviruses, including Sin Nombre virus. To determine if the antibodies elicited in the monkeys could confer protection, we performed a series of passive-transfer experiments using a recently described lethal HPS animal model (i.e., adult Syrian hamsters develop HPS and die within 10 to 15 days after challenge with ANDV). When injected into hamsters 1 day before challenge, sera from the vaccinated monkeys either provided sterile protection or delayed the onset of HPS and death. When injected on day 4 or 5 after challenge, the monkey sera protected 100% of the hamsters from lethal disease. These data provide a proof of concept for a gene-based HPS vaccine and also demonstrate the potential value of a postexposure immunoprophylactic to treat individuals after exposure, or potential exposure, to these highly lethal hantaviruses.

Effect of Vandetanib on Andes virus survival in the hamster model of Hantavirus pulmonary syndrome

2016 ◽  
Vol 132 ◽  
pp. 66-69 ◽  
Author(s):  
Brian H. Bird ◽  
Punya Shrivastava-Ranjan ◽  
Kimberly A. Dodd ◽  
Bobbie R. Erickson ◽  
Christina F. Spiropoulou
Keyword(s):  
Hantavirus Pulmonary Syndrome ◽  
Hamster Model ◽  
Andes Virus ◽  
Virus Survival

scholarly journals Andes virus associated with hantavirus pulmonary syndrome in northern Argentina and determination of the precise site of infection.

2002 ◽  
Vol 66 (6) ◽  
pp. 713-720 ◽  
Author(s):  
M Gonzalez Della Valle ◽  
J Cortez ◽  
A Edelstein ◽  
M L Cacace ◽  
S Miguel ◽  
...  
Keyword(s):  
Hantavirus Pulmonary Syndrome ◽  
Andes Virus

scholarly journals Person-to-Person Transmission of Andes Virus in Hantavirus Pulmonary Syndrome, Argentina, 2014

2020 ◽  
Vol 26 (4) ◽  
pp. 756-759 ◽  
Author(s):  
Daniel O. Alonso ◽  
Unai Pérez-Sautu ◽  
Carla M. Bellomo ◽  
Karla Prieto ◽  
Ayelén Iglesias ◽  
...  
Keyword(s):  
Hantavirus Pulmonary Syndrome ◽  
Andes Virus

scholarly journals Hantavirus Pulmonary Syndrome Outbreak in Argentina: Molecular Evidence for Person-to-Person Transmission of Andes Virus

Virology ◽  
1998 ◽  
Vol 241 (2) ◽  
pp. 323-330 ◽  
Author(s):  
P.J. Padula ◽  
A. Edelstein ◽  
S.D.L. Miguel ◽  
N.M. López ◽  
C.M. Rossi ◽  
...  
Keyword(s):  
Hantavirus Pulmonary Syndrome ◽  
Molecular Evidence ◽  
Andes Virus

scholarly journals Evidence of hantavirus infection in wild rodents captured in a rural area of the state of São Paulo, Brazil

2004 ◽  
Vol 24 (2) ◽  
pp. 71-73 ◽  
Author(s):  
Elba Regina S. de Lemos ◽  
Paulo S. D'Andrea ◽  
Cibele R. Bonvicino ◽  
Kátia M. Famadas ◽  
Paula Padula ◽  
...  
Keyword(s):  
Sao Paulo ◽  
Hantavirus Infection ◽  
São Paulo ◽  
Wild Rodents ◽  
Myocastor Coypus ◽  
Suburban Areas ◽  
Andes Virus ◽  
Etiological Agents ◽  
Antigen Antibody ◽  
Oligoryzomys Flavescens

Hantaviruses are the etiological agents of the Hantavirus Cardio-Pulmonary Syndrome, a serious rodent-borne disease in Brazil. In order to investigate the occurrence of hantavirus infection in wild rodents, a survey was conducted in three different suburban areas of the municipality of Pedreira, State of São Paulo, Brazil. Of the 145 wild animals captured belonging to 12 different species identified by morphology and karyological analysis, 107 were rodents of the following species: Akodon montensis, Bolomys lasiurus, Calomys tener, Oligoryzomys nigripes, Oligoryzomys flavescens, and Myocastor coypus. Blood samples from these rodents were assayed for the presence of antibodies against hantavirus by IgG ELISA using Andes recombinant nucleocapsid antigen. Antibody reactive to Andes virus was found in two different species, O. nigripes and O. flavescens. These results indicate a potential risk for hantavirus transmission to humans in this area, where reservoir rodents are present in peridomestic settings.

scholarly journals Ribavirin Protects Syrian Hamsters against Lethal Hantavirus Pulmonary Syndrome — After Intranasal Exposure to Andes Virus

Viruses ◽  
2013 ◽  
Vol 5 (11) ◽  
pp. 2704-2720 ◽  
Author(s):  
Monica Ogg ◽  
Colleen Jonsson ◽  
Jeremy Camp ◽  
Jay Hooper
Keyword(s):  
Hantavirus Pulmonary Syndrome ◽  
Syrian Hamsters ◽  
Andes Virus

Hantavirus Pulmonary Syndrome Due to Andes Virus in Temuco, Chile

CHEST Journal ◽  
2001 ◽  
Vol 120 (2) ◽  
pp. 548-554 ◽  
Author(s):  
Constanza Castillo ◽  
Jorge Naranjo ◽  
Alvaro Sepúlveda ◽  
Gonzalo Ossa ◽  
Howard Levy
Keyword(s):  
Hantavirus Pulmonary Syndrome ◽  
Andes Virus
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