scholarly journals Ribavirin Protects Syrian Hamsters against Lethal Hantavirus Pulmonary Syndrome — After Intranasal Exposure to Andes Virus

Viruses ◽  
2013 ◽  
Vol 5 (11) ◽  
pp. 2704-2720 ◽  
Author(s):  
Monica Ogg ◽  
Colleen Jonsson ◽  
Jeremy Camp ◽  
Jay Hooper
Keyword(s):  
Hantavirus Pulmonary Syndrome ◽  
Syrian Hamsters ◽  
Andes Virus

scholarly journals 1471. Case Report: Andes Virus Hantavirus Pulmonary Syndrome in a Traveler Returning to the United States

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S455-S455
Author(s):  
David Bergamo ◽  
Alfred Bacon ◽  
David Cohen ◽  
Paula Eggers ◽  
Aaron Kofman ◽  
...  
Keyword(s):  
United States ◽  
Case Report ◽  
The United States ◽  
Hantavirus Pulmonary Syndrome ◽  
Andes Virus

scholarly journals A Lethal Disease Model for Hantavirus Pulmonary Syndrome in Immunosuppressed Syrian Hamsters Infected with Sin Nombre Virus

2013 ◽  
Vol 88 (2) ◽  
pp. 811-819 ◽  
Author(s):  
R. L. Brocato ◽  
C. D. Hammerbeck ◽  
T. M. Bell ◽  
J. B. Wells ◽  
L. A. Queen ◽  
...  
Keyword(s):  
Disease Model ◽  
Hantavirus Pulmonary Syndrome ◽  
Sin Nombre Virus ◽  
Syrian Hamsters

scholarly journals Active and Passive Vaccination against Hantavirus Pulmonary Syndrome with Andes Virus M Genome Segment-Based DNA Vaccine

2003 ◽  
Vol 77 (18) ◽  
pp. 9894-9905 ◽  
Author(s):  
D. M. Custer ◽  
E. Thompson ◽  
C. S. Schmaljohn ◽  
T. G. Ksiazek ◽  
J. W. Hooper
Keyword(s):  
Neutralizing Antibodies ◽  
Rhesus Macaques ◽  
Case Fatality ◽  
Viral Disease ◽  
Genome Segment ◽  
Hantavirus Pulmonary Syndrome ◽  
South American ◽  
Andes Virus ◽  
Passive Vaccination ◽  
M Genome

ABSTRACT Hantavirus pulmonary syndrome (HPS) is a rapidly progressing human disease with one of the highest case fatality rates (30 to 50%) of any acute viral disease known. There are no vaccines, effective antiviral drugs, or immunologics to prevent or treat HPS. In an attempt to develop HPS medical countermeasures, we constructed an expression plasmid, pWRG/AND-M, that contains the full-length M genome segment of Andes virus (ANDV), a South American hantavirus. Transfection experiments in cell culture indicated that both the G1 and G2 glycoproteins are expressed from pWRG/AND-M. Rhesus macaques vaccinated by gene gun with pWRG/AND-M developed remarkably high levels of neutralizing antibodies that not only neutralized ANDV but also cross-neutralized other HPS-associated hantaviruses, including Sin Nombre virus. To determine if the antibodies elicited in the monkeys could confer protection, we performed a series of passive-transfer experiments using a recently described lethal HPS animal model (i.e., adult Syrian hamsters develop HPS and die within 10 to 15 days after challenge with ANDV). When injected into hamsters 1 day before challenge, sera from the vaccinated monkeys either provided sterile protection or delayed the onset of HPS and death. When injected on day 4 or 5 after challenge, the monkey sera protected 100% of the hamsters from lethal disease. These data provide a proof of concept for a gene-based HPS vaccine and also demonstrate the potential value of a postexposure immunoprophylactic to treat individuals after exposure, or potential exposure, to these highly lethal hantaviruses.

Effect of Vandetanib on Andes virus survival in the hamster model of Hantavirus pulmonary syndrome

2016 ◽  
Vol 132 ◽  
pp. 66-69 ◽  
Author(s):  
Brian H. Bird ◽  
Punya Shrivastava-Ranjan ◽  
Kimberly A. Dodd ◽  
Bobbie R. Erickson ◽  
Christina F. Spiropoulou
Keyword(s):  
Hantavirus Pulmonary Syndrome ◽  
Hamster Model ◽  
Andes Virus ◽  
Virus Survival

scholarly journals Andes virus associated with hantavirus pulmonary syndrome in northern Argentina and determination of the precise site of infection.

2002 ◽  
Vol 66 (6) ◽  
pp. 713-720 ◽  
Author(s):  
M Gonzalez Della Valle ◽  
J Cortez ◽  
A Edelstein ◽  
M L Cacace ◽  
S Miguel ◽  
...  
Keyword(s):  
Hantavirus Pulmonary Syndrome ◽  
Andes Virus

scholarly journals Person-to-Person Transmission of Andes Virus in Hantavirus Pulmonary Syndrome, Argentina, 2014

2020 ◽  
Vol 26 (4) ◽  
pp. 756-759 ◽  
Author(s):  
Daniel O. Alonso ◽  
Unai Pérez-Sautu ◽  
Carla M. Bellomo ◽  
Karla Prieto ◽  
Ayelén Iglesias ◽  
...  
Keyword(s):  
Hantavirus Pulmonary Syndrome ◽  
Andes Virus

scholarly journals Hantavirus Pulmonary Syndrome Outbreak in Argentina: Molecular Evidence for Person-to-Person Transmission of Andes Virus

Virology ◽  
1998 ◽  
Vol 241 (2) ◽  
pp. 323-330 ◽  
Author(s):  
P.J. Padula ◽  
A. Edelstein ◽  
S.D.L. Miguel ◽  
N.M. López ◽  
C.M. Rossi ◽  
...  
Keyword(s):  
Hantavirus Pulmonary Syndrome ◽  
Molecular Evidence ◽  
Andes Virus

scholarly journals Temporal Analysis of Andes Virus and Sin Nombre Virus Infections of Syrian Hamsters

2007 ◽  
Vol 81 (14) ◽  
pp. 7449-7462 ◽  
Author(s):  
Victoria Wahl-Jensen ◽  
Jennifer Chapman ◽  
Ludmila Asher ◽  
Robert Fisher ◽  
Michael Zimmerman ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Disease Onset ◽  
Treatment Strategies ◽  
Hemorrhagic Fever ◽  
Temporal Analysis ◽  
Sin Nombre Virus ◽  
Virus Infections ◽  
Syrian Hamsters ◽  
Time To Death ◽  
Andes Virus

ABSTRACT Andes virus (ANDV) and Sin Nombre virus (SNV) are rodent-borne hantaviruses that cause a highly lethal hemorrhagic fever in humans known as hantavirus pulmonary syndrome (HPS). There are no vaccines or specific drugs to prevent or treat HPS, and the pathogenesis is not understood. Syrian hamsters infected with ANDV, but not SNV, develop a highly lethal disease that closely resembles HPS in humans. Here, we performed a temporal pathogenesis study comparing ANDV and SNV infections in hamsters. SNV was nonpathogenic and viremia was not detected despite the fact that all animals were infected. ANDV was uniformly lethal with a mean time to death of 11 days. The first pathology detected was lymphocyte apoptosis starting on day 4. Animals were viremic and viral antigen was first observed in multiple organs by days 6 and 8, respectively. Levels of infectious virus in the blood increased 4 to 5 logs between days 6 and 8. Pulmonary edema was first detected ultrastructurally on day 6. Ultrastructural analysis of lung tissues revealed the presence of large inclusion bodies and substantial numbers of vacuoles within infected endothelial cells. Paraendothelial gaps were not observed, suggesting that fluid leakage was transcellular and directly attributable to infecting virus. Taken together, these data imply that HPS treatment strategies aimed at preventing virus replication and dissemination will have the greatest probability of success if administered before the viremic phase; however, because vascular leakage is associated with infected endothelial cells, a therapeutic strategy targeting viral replication might be effective even at later times (e.g., after disease onset).

scholarly journals Pathogenesis and Host Response in Syrian Hamsters following Intranasal Infection with Andes Virus

2011 ◽  
Vol 7 (12) ◽  
pp. e1002426 ◽  
Author(s):  
David Safronetz ◽  
Marko Zivcec ◽  
Rachel LaCasse ◽  
Friederike Feldmann ◽  
Rebecca Rosenke ◽  
...  
Keyword(s):  
Host Response ◽  
Intranasal Infection ◽  
Syrian Hamsters ◽  
Andes Virus
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