scholarly journals Hantavirus Pulmonary Syndrome Outbreak in Argentina: Molecular Evidence for Person-to-Person Transmission of Andes Virus

Virology ◽  
1998 ◽  
Vol 241 (2) ◽  
pp. 323-330 ◽  
Author(s):  
P.J. Padula ◽  
A. Edelstein ◽  
S.D.L. Miguel ◽  
N.M. López ◽  
C.M. Rossi ◽  
...  
Keyword(s):  
Hantavirus Pulmonary Syndrome ◽  
Molecular Evidence ◽  
Andes Virus

scholarly journals 1471. Case Report: Andes Virus Hantavirus Pulmonary Syndrome in a Traveler Returning to the United States

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S455-S455
Author(s):  
David Bergamo ◽  
Alfred Bacon ◽  
David Cohen ◽  
Paula Eggers ◽  
Aaron Kofman ◽  
...  
Keyword(s):  
United States ◽  
Case Report ◽  
The United States ◽  
Hantavirus Pulmonary Syndrome ◽  
Andes Virus

scholarly journals Active and Passive Vaccination against Hantavirus Pulmonary Syndrome with Andes Virus M Genome Segment-Based DNA Vaccine

2003 ◽  
Vol 77 (18) ◽  
pp. 9894-9905 ◽  
Author(s):  
D. M. Custer ◽  
E. Thompson ◽  
C. S. Schmaljohn ◽  
T. G. Ksiazek ◽  
J. W. Hooper
Keyword(s):  
Neutralizing Antibodies ◽  
Rhesus Macaques ◽  
Case Fatality ◽  
Viral Disease ◽  
Genome Segment ◽  
Hantavirus Pulmonary Syndrome ◽  
South American ◽  
Andes Virus ◽  
Passive Vaccination ◽  
M Genome

ABSTRACT Hantavirus pulmonary syndrome (HPS) is a rapidly progressing human disease with one of the highest case fatality rates (30 to 50%) of any acute viral disease known. There are no vaccines, effective antiviral drugs, or immunologics to prevent or treat HPS. In an attempt to develop HPS medical countermeasures, we constructed an expression plasmid, pWRG/AND-M, that contains the full-length M genome segment of Andes virus (ANDV), a South American hantavirus. Transfection experiments in cell culture indicated that both the G1 and G2 glycoproteins are expressed from pWRG/AND-M. Rhesus macaques vaccinated by gene gun with pWRG/AND-M developed remarkably high levels of neutralizing antibodies that not only neutralized ANDV but also cross-neutralized other HPS-associated hantaviruses, including Sin Nombre virus. To determine if the antibodies elicited in the monkeys could confer protection, we performed a series of passive-transfer experiments using a recently described lethal HPS animal model (i.e., adult Syrian hamsters develop HPS and die within 10 to 15 days after challenge with ANDV). When injected into hamsters 1 day before challenge, sera from the vaccinated monkeys either provided sterile protection or delayed the onset of HPS and death. When injected on day 4 or 5 after challenge, the monkey sera protected 100% of the hamsters from lethal disease. These data provide a proof of concept for a gene-based HPS vaccine and also demonstrate the potential value of a postexposure immunoprophylactic to treat individuals after exposure, or potential exposure, to these highly lethal hantaviruses.

Effect of Vandetanib on Andes virus survival in the hamster model of Hantavirus pulmonary syndrome

2016 ◽  
Vol 132 ◽  
pp. 66-69 ◽  
Author(s):  
Brian H. Bird ◽  
Punya Shrivastava-Ranjan ◽  
Kimberly A. Dodd ◽  
Bobbie R. Erickson ◽  
Christina F. Spiropoulou
Keyword(s):  
Hantavirus Pulmonary Syndrome ◽  
Hamster Model ◽  
Andes Virus ◽  
Virus Survival

scholarly journals Andes virus associated with hantavirus pulmonary syndrome in northern Argentina and determination of the precise site of infection.

2002 ◽  
Vol 66 (6) ◽  
pp. 713-720 ◽  
Author(s):  
M Gonzalez Della Valle ◽  
J Cortez ◽  
A Edelstein ◽  
M L Cacace ◽  
S Miguel ◽  
...  
Keyword(s):  
Hantavirus Pulmonary Syndrome ◽  
Andes Virus

scholarly journals Person-to-Person Transmission of Andes Virus in Hantavirus Pulmonary Syndrome, Argentina, 2014

2020 ◽  
Vol 26 (4) ◽  
pp. 756-759 ◽  
Author(s):  
Daniel O. Alonso ◽  
Unai Pérez-Sautu ◽  
Carla M. Bellomo ◽  
Karla Prieto ◽  
Ayelén Iglesias ◽  
...  
Keyword(s):  
Hantavirus Pulmonary Syndrome ◽  
Andes Virus

scholarly journals Ribavirin Protects Syrian Hamsters against Lethal Hantavirus Pulmonary Syndrome — After Intranasal Exposure to Andes Virus

Viruses ◽  
2013 ◽  
Vol 5 (11) ◽  
pp. 2704-2720 ◽  
Author(s):  
Monica Ogg ◽  
Colleen Jonsson ◽  
Jeremy Camp ◽  
Jay Hooper
Keyword(s):  
Hantavirus Pulmonary Syndrome ◽  
Syrian Hamsters ◽  
Andes Virus

Hantavirus Pulmonary Syndrome Due to Andes Virus in Temuco, Chile

CHEST Journal ◽  
2001 ◽  
Vol 120 (2) ◽  
pp. 548-554 ◽  
Author(s):  
Constanza Castillo ◽  
Jorge Naranjo ◽  
Alvaro Sepúlveda ◽  
Gonzalo Ossa ◽  
Howard Levy
Keyword(s):  
Hantavirus Pulmonary Syndrome ◽  
Andes Virus

Identification of the pulmonary syndrome hantavirus by direct and colloidal gold immune Electron Microscopy

1994 ◽  
Vol 52 ◽  
pp. 274-275
Author(s):  
C. D. Humphrey ◽  
C.S. Goldsmith ◽  
L. Elliott ◽  
S.R. Zaki
Keyword(s):  
Electron Microscopy ◽  
United States ◽  
Monoclonal Antibody ◽  
Colloidal Gold ◽  
Phosphotungstic Acid ◽  
Uranyl Acetate ◽  
Hantavirus Pulmonary Syndrome ◽  
Deer Mice ◽  
Immune Electron Microscopy ◽  
Negative Stain

An outbreak of unexplained acute pulmonary syndrome with high fatality was recognized in the spring of 1993 in the southwestern United States. The cause of the illness was quickly identified serologically and genetically as a hantavirus and the disease was named hantavirus pulmonary syndrome (HPS). Recently, the virus was isolated from deer mice which had been trapped near the homes of HPS patients, and cultivated in Vero E6 cells. We identified the cultivated virus by negative-stain direct and colloidal gold immune electron microscopy (EM).Virus was extracted, clarified, and concentrated from unfixed and 0.25% glutaraldehyde fixed supernatant fluids of infected Vero E6 cells by a procedure described previously. Concentrated virus suspensions tested by direct EM were applied to glow-discharge treated formvar-carbon filmed grids, blotted, and stained with 0.5% uranyl acetate (UA) or with 2% phosphotungstic acid (PTA) pH 6.5. Virus suspensions for immune colloidal gold identification were adsorbed similarly to filmed grids but incubated for 1 hr on drops of 1:50 diluted monoclonal antibody to Prospect Hill virus nucleoprotein or with 1:50 diluted sera from HPS virus infected deer mice.

Direct molecular evidence for the expression of the 5-HT4 receptor in rat colonocytes

2001 ◽  
Vol 120 (5) ◽  
pp. A171-A171
Author(s):  
M STONER ◽  
D YAGER ◽  
J KELLUM
Keyword(s):  
Molecular Evidence
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