Decreased expression of miR ‐24 in peripheral plasma of type 2 diabetes mellitus patients associated with diabetic foot ulcer

2020 ◽  
Vol 28 (6) ◽  
pp. 728-738
Author(s):  
Xueting Li ◽  
Ying Tang ◽  
Zeguo Jia ◽  
Xiaotong Zhao ◽  
Mingwei Chen
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Peripheral Plasma

scholarly journals Comparison Pai-1 Level in Type 2 Diabetes Mellitus with and Without Diabetic Foot Ulcer

2018 ◽  
Vol 1 (1) ◽  
pp. 1-5
Author(s):  
Alfi Dewi Sholat ◽  
Dairion Gatot ◽  
Savina Handayani ◽  
Andri Iskandar Mardia ◽  
Santi Syafril
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Diabetic Patients ◽  
Significant Difference ◽  
Pai 1

In type 2 diabetes mellitus, there are changes in hemostasis components, including overexpression of PAI-1. By these facts, the authors are interested in conducting the study of PAI-1 level in diabetic patients with and without foot ulcer. Methods: The sample of this research was collected cross-sectionally on 20 type 2 diabetic patients with foot ulcer and 20 without foot ulcer. Blood samples were taken to measure serum PAI-1 level, complete blood count and hemostasis screening test. Results: Statistical analysis showed there are significant differences in hemoglobin, trombosit, Fibrinogen and D-dimer levels in the ulcer and non-ulcer groups but no significant difference in PAI-1 level. Conclusions: No higher PAI – 1 level were found in diabetic foot ulcer group than those without diabetic foot ulcer. There was no significant difference between PAI-1 level and grade of diabetic foot ulcer.

scholarly journals Perilaku self-management dengan kejadian ulkus diabetikum pada pasien diabetes mellitus tipe 2

2020 ◽  
Vol 14 (3) ◽  
pp. 391-400
Author(s):  
Eka Yudha Chrisanto ◽  
Agustama Agustama
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Self Management ◽  
Diabetes Diet ◽  
Diabetes Melitus

Self-management behaviour of diabetic foot ulcer occurrence among patient with  type 2 diabetes mellitusBackground: Diabetes mellitus is one of the silent killers. Indonesia is a country with the 4th largest number of people with diabetes mellitus after China, India, and the United States. In Indonesia people with diabetes mellitus increased from 8.4 million in 2000 to 21.3 million in 2030.Purpose: To determine the self-management behaviour and diabetic foot ulcer occurrence among patient with  type 2 diabetes mellitus.Method: A quantitative research type, with cross sectional analytic and analytical research designs. The population of all people with diabetes mellitus as many as 432 people and a sample of 38 people with a total sampling technique. Data collection using questionnaire sheets and statistical tests used were Chi-Square statistical tests.Results: The frequency distribution of the incidence of diabetic ulcers in patients with type 2 diabetes mellitus, with the category of diabetic ulcers occurring as many as 14 respondents (36.8%). Diabetes diet adherence in patients with diabetes mellitus, with the category of non-compliance with 16 respondents (42.1%). Monitoring blood sugar levels in patients with type 2 diabetes mellitus, with non-routine categories of 15 respondents (39.5%). Physical activity in patients with type 2 diabetes mellitus, with a less good category of 19 respondents (50%).Conclusion: There is a relationship between blood sugar and diabetic ulcer diabetes in type 2 diabetes mellitus patients. There is a relationship between diabetes diet and diabetic ulcer diabetes in type 2 diabetes mellitus patients. There is a relationship between physical activity and the incidence of diabetic ulcers in patients with type 2 diabetes mellitus. It is expected that DM patients can routinely carry out physical and routine activities with high salt levels) in health care facilities and carry out a diabetes diet in accordance with the rules proposed by nutritionists.Keywords: Self-management; Behaviour; Diabetic foot ulcer; Occurrence; Patient; Type 2 diabetes mellitusPendahuluan: Diabetes melitus salah satu the silent killer. Indonesia merupakan negara dengan jumlah penderita diabetes melitus ke-4 terbanyak setelah Cina, India, dan Amerika Serikat.di Indonesia penyandang diabetes melitus mengalami kenaikan dari 8,4 juta pada tahun 2000 menjadi 21,3 juta pada tahun 2030.Tujuan: Diketahui hubungan perilaku self-management dengan kejadian ulkus diabetikum pada pasien diabetes mellitus tipe 2Metode: Jenis penelitian kuantitatif, dengan rancangan penelitian analitik dan pendekatan cross sectional. Populasi seluruh seluruh penderita diabetes melitus sebanyak 432 orang dan sampel sebanyak 38 orang dengan teknik total Sampling. Pengumpulan data menggunakan lembar kuesioner dan Uji statistik yang digunakan adalah uji statistik Chi-Square.Hasil: Distribusi frekuensi kejadian ulkus diabetikum pada penderita diabetes melitus tipe 2, dengan kategori terjadi ulkus diabetikum sebanyak 14 responden (36,8%). Kepatuhan diet diabetes pada pasien diabetes melitus, dengan kategori tidak patuh sebanyak 16 responden (42,1%). Pemantauan kadar gula darah pada pasien diabetes melitus tipe 2, dengan kategori tidak rutin sebanyak 15 responden (39,5%). Aktivitas fisik pada pasien diabetes melitus tipe 2, dengan kategori kurang baik sebanyak 19 responden (50%).Simpulan: Ada hubungan pemantauan kadar gula darah dengan kejadian ulkus diabetikum pada pasien diabetes melitus tipe 2. Ada hubungan kepatuhan diet diabetes dengan kejadian ulkus diabetikum pada pasien diabetes melitus tipe 2. Ada hubungan aktivitas fisik dengan kejadian ulkus diabetikum pada pasien diabetes melitus tipe 2. Diharapkan pasien DM agar rutin melakukan aktivitas fisik  serta rutin mengontrol kadar gula darah pada fasilitas pelayanan kesehatan Serta menjalankan diet diabetes sesuai dengan aturan yang disarankan ahli gizi.

scholarly journals Angiopoietin 2 in type 2 diabetes mellitus patients and those with complications: an observational comparative study

2020 ◽  
Vol 7 (5) ◽  
pp. 733
Author(s):  
Kishan Raj K.
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Study Groups ◽  
Diabetic Patients ◽  
Duration Of Diabetes ◽  
Angiopoietin 2

Background: Angiopoietin 2 levels in blood signifies neo vascularization. Only biomarker available now for routine check up is HbA1c. However, it doesn’t suggest if patient is more prone to get into complications than the other. Here, we try to bring in another biomarker Angiopoietin 2 and elucidate if it can identify patients going in for complications of type 2 diabetes mellitus early.Methods: Total 60 diabetic patients were studied over a span of 1 year. 30 were diabetic without any complciations and another 30 were with complications (Diabetic foot ulcer, Diabetic retinopathy, Diabetic nephropathy, Diabetic neuropathy). Angiopoietin 2 levels were estimated in both the groups and compared.Results: Analysis showed Mean duration of Diabetes was significantly lower in patients without complication than those with complications. Human angiopoietin 2 levels were elevated in both the study groups. More so, in the study group with Diabetic patients with complications. It was statistically significant. (p<0.001).There was no significant relationship between duration of diabetes and Human angiopoietin 2 levels.Conclusions: It was found that angiopoietin 2 is also a good biomarker for diabetes as HbA1c. It also helps in detection of complications earlier and thus may help in reducing morbidity as well as mortality. Further studies are required to strengthen the information got from this study to compare efficacy of HbA1c and angiopoietin 2 as well as how early can we detect the patients who may land up in complications. 

scholarly journals Pengaruh Range of Motion (ROM) Aktif Kaki terhadap Risiko terjadinya Ulkus Kaki Diabetik pada Pasien Diabetes Mellitus Tipe 2 di Desa Kaliwining Kabupaten Jember

2018 ◽  
Vol 6 (2) ◽  
pp. 305
Author(s):  
Yulfa Intan Lukita ◽  
Nur Widyati ◽  
Wantiyah Wantiyah
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Range Of Motion ◽  
Diabetic Foot ◽  
Intervention Group ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Control Group ◽  
Significant Difference

Diabetic foot ulcer is one of serious complications in diabetic patients which can lead to amputation.Active Leg range of motion (ROM) exercise is one of physical activities which can improve bloodcirculation in lower extremities. The objective of this research was to analyze the effect of active legROM on the risk of diabetic foot ulcer. This research employed non randomized control group pretestpostest design. The sampling technique was purposive sampling involving 30 repondents whichwere divided into 15 respondents as intervention group and 15 respondents as control group. Thedata were analyzed using dependent t test and independent t test with significant level of 0.05. Theresult revealed a significant difference between pretest and posttest in the intervention group (p =0.000) but no significant difference in the control group (p = 0.582). Furthemore, independent t testshowed a significant difference between intervention group and control group (p = 0.000). This resultindicates that there is a significant effect of active leg ROM on the risk of diabetic foot ulcer in clientwith type 2 diabetes mellitus. Nurse is expected to apply range of motion as one of intervention toprevent diabetic foot ulcer in diabetes mellitus patients.Keywords: type 2 diabetes mellitus, active leg range of motion, risk of diabetic foot ulcer

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