Hyperbaric oxygen therapy activates hypoxia-inducible factor 1 (HIF-1), which contributes to improved wound healing in diabetic mice

2015 ◽  
Vol 23 (1) ◽  
pp. 98-103 ◽  
Author(s):  
Vivekananda Gupta Sunkari ◽  
Folke Lind ◽  
Ileana Ruxandra Botusan ◽  
Abad Kashif ◽  
Zhao-Jun Liu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Hypoxia Inducible Factor ◽  
Diabetic Mice ◽  
Hypoxia Inducible Factor 1

Hyperbaric oxygen therapy accelerates wound healing in diabetic mice by decreasing active matrix metalloproteinase‐9

2019 ◽  
Vol 28 (2) ◽  
pp. 194-201 ◽  
Author(s):  
Trung T. Nguyen ◽  
Jeffrey I. Jones ◽  
William R. Wolter ◽  
Rocio L. Pérez ◽  
Valerie A. Schroeder ◽  
...  
Keyword(s):  
Wound Healing ◽  
Matrix Metalloproteinase ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Matrix Metalloproteinase 9 ◽  
Diabetic Mice ◽  
Active Matrix ◽  
Metalloproteinase 9

Does Hyperbaric Oxygen Therapy Work in Facilitating Acute Wound Healing

2014 ◽  
Vol 133 (2) ◽  
pp. 208e-215e ◽  
Author(s):  
Phillip B. Dauwe ◽  
Benson J. Pulikkottil ◽  
Lawrence Lavery ◽  
James M. Stuzin ◽  
Rod J. Rohrich
Keyword(s):  
Wound Healing ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Acute Wound

scholarly journals Oxidative stress is fundamental to hyperbaric oxygen therapy

2009 ◽  
Vol 106 (3) ◽  
pp. 988-995 ◽  
Author(s):  
Stephen R. Thom
Keyword(s):  
Oxidative Stress ◽  
Signal Transduction ◽  
Wound Healing ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Reactive Species ◽  
Controlled Clinical Trials ◽  
Therapeutic Mechanisms ◽  
Cell Signal Transduction

The goal of this review is to outline advances addressing the role that reactive species of oxygen and nitrogen play in therapeutic mechanisms of hyperbaric oxygen. The review will be organized around major categories of problems or processes where controlled clinical trials have demonstrated clinical efficacy for hyperbaric oxygen therapy. Reactive species are now recognized to play a major role in cell signal transduction cascades, and the discussion will focus on how hyperbaric oxygen acts through these pathways to mediate wound healing and ameliorate postischemic and inflammatory injuries.

Effects of hyperbaric oxygen therapy on uncomplicated incisional and open wound healing in dogs

2018 ◽  
Vol 47 (6) ◽  
pp. 827-836 ◽  
Author(s):  
Christian R. Latimer ◽  
Cassie N. Lux ◽  
Sarah Roberts ◽  
Marti G. Drum ◽  
Cheryl Braswell ◽  
...  
Keyword(s):  
Wound Healing ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Open Wound

The effect of hyperbaric oxygen therapy on the adverse effects of octreotide on wound healing

2004 ◽  
Vol 16 (5) ◽  
pp. 475-478 ◽  
Author(s):  
Senol Yildiz ◽  
Haldun Uluutku ◽  
Alp Gunay ◽  
I2smail Yildirim ◽  
??ukru Yildirim ◽  
...  
Keyword(s):  
Wound Healing ◽  
Adverse Effects ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy

scholarly journals BASIC MECHANISM OF HYPERBARIC OXYGEN IN INFECTIOUS DISEASE

2016 ◽  
Vol 2 (1) ◽  
pp. 49 ◽  
Author(s):  
Prihartini Widiyanti
Keyword(s):  
Infectious Disease ◽  
Wound Healing ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Side Effect ◽  
Oxygen Therapy ◽  
Basic Mechanism ◽  
Cumulative Number ◽  
Hyperbaric Chamber ◽  
Increased Pressure

Hyperbaric oxygen therapy (HBOT) is the inhalation of 100 percent oxygen inside a hyperbaric chamber that is pressurized to greater than 1 atmosphere (atm). HBOT causes both mechanical and physiologic effects by inducing a state of increased pressure and hyperoxia. HBOT is typically administered at 1 to 3 atm. While the duration of an HBOT session is typically 90 to 120 minutes, the duration, frequency, and cumulative number of sessions have not been standardized. HBO has been use widely in treating gangrene diabetic, stroke, osteomyelitis and accelerating wound healing. The use of HBO in infectious disease is wide, so the mechanism of hyperbaric oxygen in infectious disease should be well-understand. This understanding could bring the proper and wise management of infectious disease and to prevent the side effect of each therapy.

scholarly journals Hyperbaric Oxygen Therapy for Venous Leg Ulcers: A 6 Year Retrospective Study of Results of a Single Center

2021 ◽  
Vol 8 ◽  
Author(s):  
Rutger C. Lalieu ◽  
Ida Akkerman ◽  
Rob A. van Hulst
Keyword(s):  
Wound Healing ◽  
Pain Score ◽  
Outcome Measures ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Leg Ulcers ◽  
Single Center ◽  
Venous Leg Ulcers ◽  
Number Of Patients

Background: Venous leg ulcers (VLUs) are common and have a large impact on healthcare budgets worldwide. Hyperbaric oxygen therapy (HBOT) may improve healing of these ulcers.Methods: Retrospective, single-center cohort study between 2013 and 2019. All patients with a VLU from an outpatient clinic providing HBOT and wound care were included. The primary outcome measure was wound healing, determined at discharge from the center. Other outcome measures were improvement in patient related outcome measures (PROMs), as assessed by the EQ-5D-3L questionnaire and including quality of life (QoL) and pain score.Results: Fifty patients were included, 53% female, with a mean age of 73.4 (±12.2). Most wounds (83%) had existed longer than 3 months before starting treatment. Patients received an average of 43 (±20) sessions of HBOT. After treatment, 37 patients (63%) achieved complete or near-complete wound healing. Wound size decreased from a median of 14 cm2 [interquartile range (IQR) 32 cm2] to 0.5 cm2 (IQR 5.3 cm2), a median decrease of 7.5 (IQR 16.2 cm2) in cm2 (94%). Patients mostly reported improvement for all health aspects on the questionnaire. Pain score decreased from 5.7 (±2.5) to 2.1 (±2.2) (p < 0.0001) and health score increased from 57.2 (±15.6) to 69.9 (±18.9) (p = 0.02).Conclusions: Patients with non-healing VLUs may benefit from HBOT to achieve complete or substantial wound healing. We recommend a well-designed randomized clinical trial with a number of patients allowing enough statistical power, and of a reasonable duration, to establish the potential of additional HBOT on hard-to-heal venous ulcers.

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