Effects of hyperbaric oxygen therapy on uncomplicated incisional and open wound healing in dogs

2018 ◽  
Vol 47 (6) ◽  
pp. 827-836 ◽  
Author(s):  
Christian R. Latimer ◽  
Cassie N. Lux ◽  
Sarah Roberts ◽  
Marti G. Drum ◽  
Cheryl Braswell ◽  
...  
Keyword(s):  
Wound Healing ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Open Wound

Does Hyperbaric Oxygen Therapy Work in Facilitating Acute Wound Healing

2014 ◽  
Vol 133 (2) ◽  
pp. 208e-215e ◽  
Author(s):  
Phillip B. Dauwe ◽  
Benson J. Pulikkottil ◽  
Lawrence Lavery ◽  
James M. Stuzin ◽  
Rod J. Rohrich
Keyword(s):  
Wound Healing ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Acute Wound

scholarly journals Oxidative stress is fundamental to hyperbaric oxygen therapy

2009 ◽  
Vol 106 (3) ◽  
pp. 988-995 ◽  
Author(s):  
Stephen R. Thom
Keyword(s):  
Oxidative Stress ◽  
Signal Transduction ◽  
Wound Healing ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Reactive Species ◽  
Controlled Clinical Trials ◽  
Therapeutic Mechanisms ◽  
Cell Signal Transduction

The goal of this review is to outline advances addressing the role that reactive species of oxygen and nitrogen play in therapeutic mechanisms of hyperbaric oxygen. The review will be organized around major categories of problems or processes where controlled clinical trials have demonstrated clinical efficacy for hyperbaric oxygen therapy. Reactive species are now recognized to play a major role in cell signal transduction cascades, and the discussion will focus on how hyperbaric oxygen acts through these pathways to mediate wound healing and ameliorate postischemic and inflammatory injuries.

The effect of hyperbaric oxygen therapy on the adverse effects of octreotide on wound healing

2004 ◽  
Vol 16 (5) ◽  
pp. 475-478 ◽  
Author(s):  
Senol Yildiz ◽  
Haldun Uluutku ◽  
Alp Gunay ◽  
I2smail Yildirim ◽  
??ukru Yildirim ◽  
...  
Keyword(s):  
Wound Healing ◽  
Adverse Effects ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy

scholarly journals BASIC MECHANISM OF HYPERBARIC OXYGEN IN INFECTIOUS DISEASE

2016 ◽  
Vol 2 (1) ◽  
pp. 49 ◽  
Author(s):  
Prihartini Widiyanti
Keyword(s):  
Infectious Disease ◽  
Wound Healing ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Side Effect ◽  
Oxygen Therapy ◽  
Basic Mechanism ◽  
Cumulative Number ◽  
Hyperbaric Chamber ◽  
Increased Pressure

Hyperbaric oxygen therapy (HBOT) is the inhalation of 100 percent oxygen inside a hyperbaric chamber that is pressurized to greater than 1 atmosphere (atm). HBOT causes both mechanical and physiologic effects by inducing a state of increased pressure and hyperoxia. HBOT is typically administered at 1 to 3 atm. While the duration of an HBOT session is typically 90 to 120 minutes, the duration, frequency, and cumulative number of sessions have not been standardized. HBO has been use widely in treating gangrene diabetic, stroke, osteomyelitis and accelerating wound healing. The use of HBO in infectious disease is wide, so the mechanism of hyperbaric oxygen in infectious disease should be well-understand. This understanding could bring the proper and wise management of infectious disease and to prevent the side effect of each therapy.

scholarly journals Hyperbaric Oxygen Therapy for Venous Leg Ulcers: A 6 Year Retrospective Study of Results of a Single Center

2021 ◽  
Vol 8 ◽  
Author(s):  
Rutger C. Lalieu ◽  
Ida Akkerman ◽  
Rob A. van Hulst
Keyword(s):  
Wound Healing ◽  
Pain Score ◽  
Outcome Measures ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Leg Ulcers ◽  
Single Center ◽  
Venous Leg Ulcers ◽  
Number Of Patients

Background: Venous leg ulcers (VLUs) are common and have a large impact on healthcare budgets worldwide. Hyperbaric oxygen therapy (HBOT) may improve healing of these ulcers.Methods: Retrospective, single-center cohort study between 2013 and 2019. All patients with a VLU from an outpatient clinic providing HBOT and wound care were included. The primary outcome measure was wound healing, determined at discharge from the center. Other outcome measures were improvement in patient related outcome measures (PROMs), as assessed by the EQ-5D-3L questionnaire and including quality of life (QoL) and pain score.Results: Fifty patients were included, 53% female, with a mean age of 73.4 (±12.2). Most wounds (83%) had existed longer than 3 months before starting treatment. Patients received an average of 43 (±20) sessions of HBOT. After treatment, 37 patients (63%) achieved complete or near-complete wound healing. Wound size decreased from a median of 14 cm2 [interquartile range (IQR) 32 cm2] to 0.5 cm2 (IQR 5.3 cm2), a median decrease of 7.5 (IQR 16.2 cm2) in cm2 (94%). Patients mostly reported improvement for all health aspects on the questionnaire. Pain score decreased from 5.7 (±2.5) to 2.1 (±2.2) (p < 0.0001) and health score increased from 57.2 (±15.6) to 69.9 (±18.9) (p = 0.02).Conclusions: Patients with non-healing VLUs may benefit from HBOT to achieve complete or substantial wound healing. We recommend a well-designed randomized clinical trial with a number of patients allowing enough statistical power, and of a reasonable duration, to establish the potential of additional HBOT on hard-to-heal venous ulcers.

Effect of HBO therapy on adipose-derived stem cells, fibroblasts and co-cultures: In vitro study of oxidative stress, angiogenic potential and production of pro-inflammatory growth factors in co-cultures1

2020 ◽  
pp. 1-13
Author(s):  
P. Engel ◽  
M. Ranieri ◽  
O. Felthaus ◽  
S. Geis ◽  
F. Haubner ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Wound Healing ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Reactive Oxygen ◽  
Adipose Derived Stem Cells ◽  
Oxygen Species

BACKGROUND: A key moderator of wound healing is oxygen. Wound healing is a dynamic and carefully orchestrated process involving blood cells, cytokines, parenchymal cells (i.e. fibroblasts and mesenchymal stem cells) and extracellular matrix reorganization. Human adipose derived stem cells as well as human fibroblasts produce soluble factors, exhibit diverse effects on inflammation and anti inflammation response and are involved in wound healing processes. Hyperbaric oxygen therapy is an effective adjunct treatment for ischemic disorders such as chronic infection or chronic wounds. In vitro effects of hyperbaric oxygen therapy on human cells were presented in many studies except for those on mono- and co-cultures of human adipose derived stem cells and fibroblasts. OBJECTIVE: The aim of this study was to investigate the effects of hyperbaric oxygen therapy on mono- and co-cultures of human adipose derived stem cells and fibroblasts. METHODS: Mono- and co-cultures from human adipose derived stem cells and fibroblasts were established. These cultures were exposed to hyperbaric oxygen therapy every 24 h for five consecutive days. Measuring experiments were performed on the first, third and fifth day. Therapy effects on the expression of VEGF, IL 6 and reactive oxygen species were investigated. RESULTS: After exposure to hyperbaric oxygen, cell culturess showed a significant increase in the expression of VEGF after 3 and 5 days. All cultures showed significantly reduced formation of reactive oxygen species throughout the experiments. The expression of IL-6 decreased during the experiment in mono-cultures of human adipose derived stem cells and co-cultures. In contrast, mono-cultures of human skin fibroblasts showed an overall significantly increased expression of IL-6. CONCLUSIONS: Hyperbaric oxygen therapy leads to immunmodulatory and proangiogenetic effects in a wound-like enviroment of adipose derived stem cells and fibroblasts.

scholarly journals Hyperbaric Oxygen Therapy to Treat Diabetes Impaired Wound Healing in Rats

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e108533 ◽  
Author(s):  
Bastiaan Tuk ◽  
Miao Tong ◽  
Esther M. G. Fijneman ◽  
Johan W. van Neck
Keyword(s):  
Wound Healing ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Impaired Wound Healing
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