Administration of platelet concentrates suspended in bicarbonated Ringer's solution in children who had platelet transfusion reactions

Vox Sanguinis ◽  
2017 ◽  
Vol 113 (2) ◽  
pp. 128-135 ◽  
Author(s):  
J. Kobayashi ◽  
R. Yanagisawa ◽  
T. Ono ◽  
Y. Tatsuzawa ◽  
Y. Tokutake ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Platelet Concentrates ◽  
Ringer’S Solution ◽  
Transfusion Reactions

Platelet transfusion reactions do not occur more often in recipients transfused with apheresis versus buffy coat platelet concentrates

Transfusion ◽  
2016 ◽  
Vol 56 (12) ◽  
pp. 3144-3146 ◽  
Author(s):  
Christine Cserti-Gazdewich ◽  
Alioska Escorcia ◽  
Jacob Pendergrast ◽  
Lani Lieberman ◽  
Robert Skeate ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Buffy Coat ◽  
Platelet Concentrates ◽  
Transfusion Reactions

scholarly journals Correction of poor platelet transfusion responses with leukocyte-poor HL-A-matched platelet concentrates

Blood ◽  
1975 ◽  
Vol 46 (5) ◽  
pp. 743-750 ◽  
Author(s):  
RH Herzig ◽  
GP Herzig ◽  
MI Bull ◽  
JA Decter ◽  
HP Lohrmann ◽  
...  
Keyword(s):  
Blood Cells ◽  
Platelet Transfusion ◽  
White Blood Cells ◽  
Innocent Bystander ◽  
Platelet Concentrates ◽  
Simple Method ◽  
The Poor ◽  
Starting Point ◽  
Antigen Antibody ◽  
Transfusion Reactions

Matching donor-recipient pairs for HL-A antigens provides a logical starting point for selecting donors for recipients with extensive prior transfusion histories. However, during the course of continued exposure to even HL-A-matched platelet concentrates, further sensitization occurs, as indicated by progressively poorer post-transfusion increments and transfusion reactions. There is evidence that such sensitization may be due to non-HL-A antigens. Finally, it is postulated that the poor post-transfusion platelet increments obtained when standard platelet concentrates are used result from the leukoagglutinin antigen-antibody reaction involving the platelet as an “innocent bystander.” The standard platelet concentrate can be purified by a simple method of centrifugation (178 g times 3 min), removing about 96% of the contaminating white blood cells with concomitant loss of about 21% of the platelets. The use of these leukocyte-poor platelet concentrates can restore compatible transfusion increments in highly alloimmunized thrombocytopenic recipients. The luekocyte-poor concentrates can diminish undesirable transfusion reactions following imcompatible platelet transfusions.

Prevalence of Platelet Transfusion Reactions Before and After Implementation of Leukocyte-Depleted Platelet Concentrates by Filtration

Vox Sanguinis ◽  
1993 ◽  
Vol 65 (2) ◽  
pp. 103-107 ◽  
Author(s):  
Lawrence Tim Goodnough ◽  
James Riddell ◽  
Hillard Lazarus ◽  
Theresa L. Chafel ◽  
Greg Prince ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Platelet Concentrates ◽  
Before And After ◽  
Transfusion Reactions

scholarly journals Correction of poor platelet transfusion responses with leukocyte-poor HL-A-matched platelet concentrates

Blood ◽  
1975 ◽  
Vol 46 (5) ◽  
pp. 743-750 ◽  
Author(s):  
RH Herzig ◽  
GP Herzig ◽  
MI Bull ◽  
JA Decter ◽  
HP Lohrmann ◽  
...  
Keyword(s):  
Blood Cells ◽  
Platelet Transfusion ◽  
White Blood Cells ◽  
Innocent Bystander ◽  
Platelet Concentrates ◽  
Simple Method ◽  
The Poor ◽  
Starting Point ◽  
Antigen Antibody ◽  
Transfusion Reactions

Abstract Matching donor-recipient pairs for HL-A antigens provides a logical starting point for selecting donors for recipients with extensive prior transfusion histories. However, during the course of continued exposure to even HL-A-matched platelet concentrates, further sensitization occurs, as indicated by progressively poorer post-transfusion increments and transfusion reactions. There is evidence that such sensitization may be due to non-HL-A antigens. Finally, it is postulated that the poor post-transfusion platelet increments obtained when standard platelet concentrates are used result from the leukoagglutinin antigen-antibody reaction involving the platelet as an “innocent bystander.” The standard platelet concentrate can be purified by a simple method of centrifugation (178 g times 3 min), removing about 96% of the contaminating white blood cells with concomitant loss of about 21% of the platelets. The use of these leukocyte-poor platelet concentrates can restore compatible transfusion increments in highly alloimmunized thrombocytopenic recipients. The luekocyte-poor concentrates can diminish undesirable transfusion reactions following imcompatible platelet transfusions.

Prevalence of Platelet Transfusion Reactions Before and After Implementation of Leukocyte-Depleted Platelet Concentrates by Filtration

Vox Sanguinis ◽  
1993 ◽  
Vol 65 (2) ◽  
pp. 103-107 ◽  
Author(s):  
Lawrence Tim Goodnough ◽  
James Riddell ◽  
Hillard Lazarus ◽  
Theresa L. Chafel ◽  
Greg Prince ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Platelet Concentrates ◽  
Before And After ◽  
Transfusion Reactions

Removal of biologic response modifiers associated with platelet transfusion reactions: strategies worth considering?

Transfusion ◽  
2014 ◽  
Vol 54 (10) ◽  
pp. 2583-2583 ◽  
Author(s):  
Olivier Garraud ◽  
Fabrice Cognasse ◽  
Hind Hamzeh-Cognasse ◽  
Sherry Spinelli ◽  
Richard P. Phipps ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Biologic Response ◽  
Transfusion Reactions

Effect of premedication guidelines and leukoreduction on the rate of febrile nonhaemolytic platelet transfusion reactions

2000 ◽  
Vol 10 (3) ◽  
pp. 199-206 ◽  
Author(s):  
Patterson ◽  
Freedman ◽  
Blanchette ◽  
Sher ◽  
Pinkerton ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Transfusion Reactions

Relationship of the time of storage and transfusion reactions to platelet concentrates from buffy coats

Transfusion ◽  
1997 ◽  
Vol 37 (5) ◽  
pp. 528-530 ◽  
Author(s):  
D Riccardi ◽  
E Raspollini ◽  
P Rebulla ◽  
M Pappalettera ◽  
F Marangoni ◽  
...  
Keyword(s):  
Platelet Concentrates ◽  
Relationship Of ◽  
Transfusion Reactions

scholarly journals High-dose intravenous gammaglobulin in alloimmunized platelet transfusion recipients

Blood ◽  
1984 ◽  
Vol 64 (4) ◽  
pp. 937-940 ◽  
Author(s):  
CA Schiffer ◽  
DE Hogge ◽  
J Aisner ◽  
JP Dutcher ◽  
EJ Lee ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Reticuloendothelial System ◽  
Final Concentration ◽  
Red Cross ◽  
High Dose ◽  
Platelet Concentrates ◽  
Intravenous Gammaglobulin ◽  
G Prior ◽  
Polyvalent Immunoglobulin ◽  
Lymphocytotoxic Antibody

Abstract High-dose intravenous gammaglobulin (polyvalent immunoglobulin G) has been shown to be of benefit in some patients with immune thrombocytopenic purpura (ITP), possibly by producing reticuloendothelial system blockade. We studied this approach in patients refractory to random donor platelet transfusion using an IV IgG preparation manufactured by the Swiss Red Cross. Eleven adult patients with acute leukemia received either 0.4 g IgG/kg/d intravenously X five days (four patients) or 0.6 g/kg/d X five days (seven patients). All patients had high levels of lymphocytotoxic antibody and poor responses to random donor platelets. Except for mild headaches in two patients, there were no side effects related to the IgG infusions. All patients had significant elevations of serum IgG on the day after completion of treatment. Either random donor or partially HLA-matched platelet transfusions were administered the day after and, in some cases, during the IgG therapy. No patient had an improvement in one hour posttransfusion platelet count increments. Two additional patients received pooled platelet concentrates incubated for 30 minutes at 37 degrees C with IgG at a final concentration of 3 g% prior to transfusions. These results indicate that high-dose IgG, an extremely expensive treatment, cannot be recommended for alloimmunized adults with leukemia.

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