Prevalence of Platelet Transfusion Reactions Before and After Implementation of Leukocyte-Depleted Platelet Concentrates by Filtration

Vox Sanguinis ◽  
1993 ◽  
Vol 65 (2) ◽  
pp. 103-107 ◽  
Author(s):  
Lawrence Tim Goodnough ◽  
James Riddell ◽  
Hillard Lazarus ◽  
Theresa L. Chafel ◽  
Greg Prince ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Platelet Concentrates ◽  
Before And After ◽  
Transfusion Reactions

Prevalence of Platelet Transfusion Reactions Before and After Implementation of Leukocyte-Depleted Platelet Concentrates by Filtration

Vox Sanguinis ◽  
1993 ◽  
Vol 65 (2) ◽  
pp. 103-107 ◽  
Author(s):  
Lawrence Tim Goodnough ◽  
James Riddell ◽  
Hillard Lazarus ◽  
Theresa L. Chafel ◽  
Greg Prince ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Platelet Concentrates ◽  
Before And After ◽  
Transfusion Reactions

Administration of platelet concentrates suspended in bicarbonated Ringer's solution in children who had platelet transfusion reactions

Vox Sanguinis ◽  
2017 ◽  
Vol 113 (2) ◽  
pp. 128-135 ◽  
Author(s):  
J. Kobayashi ◽  
R. Yanagisawa ◽  
T. Ono ◽  
Y. Tatsuzawa ◽  
Y. Tokutake ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Platelet Concentrates ◽  
Ringer’S Solution ◽  
Transfusion Reactions

Platelet transfusion reactions do not occur more often in recipients transfused with apheresis versus buffy coat platelet concentrates

Transfusion ◽  
2016 ◽  
Vol 56 (12) ◽  
pp. 3144-3146 ◽  
Author(s):  
Christine Cserti-Gazdewich ◽  
Alioska Escorcia ◽  
Jacob Pendergrast ◽  
Lani Lieberman ◽  
Robert Skeate ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Buffy Coat ◽  
Platelet Concentrates ◽  
Transfusion Reactions

scholarly journals Correction of poor platelet transfusion responses with leukocyte-poor HL-A-matched platelet concentrates

Blood ◽  
1975 ◽  
Vol 46 (5) ◽  
pp. 743-750 ◽  
Author(s):  
RH Herzig ◽  
GP Herzig ◽  
MI Bull ◽  
JA Decter ◽  
HP Lohrmann ◽  
...  
Keyword(s):  
Blood Cells ◽  
Platelet Transfusion ◽  
White Blood Cells ◽  
Innocent Bystander ◽  
Platelet Concentrates ◽  
Simple Method ◽  
The Poor ◽  
Starting Point ◽  
Antigen Antibody ◽  
Transfusion Reactions

Matching donor-recipient pairs for HL-A antigens provides a logical starting point for selecting donors for recipients with extensive prior transfusion histories. However, during the course of continued exposure to even HL-A-matched platelet concentrates, further sensitization occurs, as indicated by progressively poorer post-transfusion increments and transfusion reactions. There is evidence that such sensitization may be due to non-HL-A antigens. Finally, it is postulated that the poor post-transfusion platelet increments obtained when standard platelet concentrates are used result from the leukoagglutinin antigen-antibody reaction involving the platelet as an “innocent bystander.” The standard platelet concentrate can be purified by a simple method of centrifugation (178 g times 3 min), removing about 96% of the contaminating white blood cells with concomitant loss of about 21% of the platelets. The use of these leukocyte-poor platelet concentrates can restore compatible transfusion increments in highly alloimmunized thrombocytopenic recipients. The luekocyte-poor concentrates can diminish undesirable transfusion reactions following imcompatible platelet transfusions.

scholarly journals Correction of poor platelet transfusion responses with leukocyte-poor HL-A-matched platelet concentrates

Blood ◽  
1975 ◽  
Vol 46 (5) ◽  
pp. 743-750 ◽  
Author(s):  
RH Herzig ◽  
GP Herzig ◽  
MI Bull ◽  
JA Decter ◽  
HP Lohrmann ◽  
...  
Keyword(s):  
Blood Cells ◽  
Platelet Transfusion ◽  
White Blood Cells ◽  
Innocent Bystander ◽  
Platelet Concentrates ◽  
Simple Method ◽  
The Poor ◽  
Starting Point ◽  
Antigen Antibody ◽  
Transfusion Reactions

Abstract Matching donor-recipient pairs for HL-A antigens provides a logical starting point for selecting donors for recipients with extensive prior transfusion histories. However, during the course of continued exposure to even HL-A-matched platelet concentrates, further sensitization occurs, as indicated by progressively poorer post-transfusion increments and transfusion reactions. There is evidence that such sensitization may be due to non-HL-A antigens. Finally, it is postulated that the poor post-transfusion platelet increments obtained when standard platelet concentrates are used result from the leukoagglutinin antigen-antibody reaction involving the platelet as an “innocent bystander.” The standard platelet concentrate can be purified by a simple method of centrifugation (178 g times 3 min), removing about 96% of the contaminating white blood cells with concomitant loss of about 21% of the platelets. The use of these leukocyte-poor platelet concentrates can restore compatible transfusion increments in highly alloimmunized thrombocytopenic recipients. The luekocyte-poor concentrates can diminish undesirable transfusion reactions following imcompatible platelet transfusions.

Removal of biologic response modifiers associated with platelet transfusion reactions: strategies worth considering?

Transfusion ◽  
2014 ◽  
Vol 54 (10) ◽  
pp. 2583-2583 ◽  
Author(s):  
Olivier Garraud ◽  
Fabrice Cognasse ◽  
Hind Hamzeh-Cognasse ◽  
Sherry Spinelli ◽  
Richard P. Phipps ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Biologic Response ◽  
Transfusion Reactions

Effect of premedication guidelines and leukoreduction on the rate of febrile nonhaemolytic platelet transfusion reactions

2000 ◽  
Vol 10 (3) ◽  
pp. 199-206 ◽  
Author(s):  
Patterson ◽  
Freedman ◽  
Blanchette ◽  
Sher ◽  
Pinkerton ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Transfusion Reactions

scholarly journals A randomized, placebo-controlled trial of intravenous gammaglobulin in alloimmunized thrombocytopenic patients

Blood ◽  
1990 ◽  
Vol 75 (1) ◽  
pp. 313-316 ◽  
Author(s):  
T Kickler ◽  
HG Braine ◽  
S Piantadosi ◽  
PM Ness ◽  
JH Herman ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Controlled Trial ◽  
Parameter Estimate ◽  
Control Group ◽  
Platelet Recovery ◽  
Mean Values ◽  
Blinded Study ◽  
Before And After ◽  
Study Population ◽  
Intravenous Gammaglobulin

Abstract In a placebo-controlled, randomized blinded study, we evaluated the efficacy of intravenous gammaglobulin (IV-IgG) in alloimmunized thrombocytopenic patients. IV-IgG was administered at a dose of 400 mg/kg for 5 days. An incompatible platelet transfusion from the same donor was used before and after treatment. Seven patients received IV- IgG and five patients received placebo. Although platelet recovery in 1 to 6 hours was satisfactory in five patients after IV-IgG treatment, 24- hour survival was not improved in most patients. None of the patients receiving the placebo achieved satisfactory 1-hour platelet-corrected count increments (CCIs). By t test, the posttreatment mean values 1 hour after transfusion CCIs in the IV-IgG group were significantly greater than in the control group (8,413 v 1,050, P less than .007). Using a regression model to adjust for any distributional assumptions of the study population, the parameter estimate for IV-IgG treatment was positive, indicating that IV-IgG treatment is associated with higher CCIs. Although IV-IgG may improve 1-hour platelet recovery, clinical benefit was not demonstrated since 24-hour survival was not improved. IV-IgG treatment before unmatched platelet transfusions should not be considered as a replacement for HLA-compatible platelets in alloimmunized patients.

Relationship of the time of storage and transfusion reactions to platelet concentrates from buffy coats

Transfusion ◽  
1997 ◽  
Vol 37 (5) ◽  
pp. 528-530 ◽  
Author(s):  
D Riccardi ◽  
E Raspollini ◽  
P Rebulla ◽  
M Pappalettera ◽  
F Marangoni ◽  
...  
Keyword(s):  
Platelet Concentrates ◽  
Relationship Of ◽  
Transfusion Reactions

Global hemostasis tests in patients with cirrhosis before and after prophylactic platelet transfusion

2012 ◽  
Vol 33 (3) ◽  
pp. 362-367 ◽  
Author(s):  
Armando Tripodi ◽  
Massimo Primignani ◽  
Veena Chantarangkul ◽  
Laura Lemma ◽  
Manol Jovani ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Before And After
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