Platelet transfusion reactions: Febrile nonhemolytic reaction or bacterial contamination? Diagnosis, detection, and current preventive modalities

2000 ◽  
Vol 14 (4) ◽  
pp. 460-466 ◽  
Author(s):  
Ajeet D. Sharma ◽  
Hilary P. Grocott
Keyword(s):  
Platelet Transfusion ◽  
Bacterial Contamination ◽  
Transfusion Reactions

scholarly journals Platelet transfusion therapy in sub-Saharan Africa: bacterial contamination, recipient characteristics, and acute transfusion reactions

Transfusion ◽  
2016 ◽  
Vol 56 (8) ◽  
pp. 1951-1959 ◽  
Author(s):  
Heather A. Hume ◽  
Henry Ddungu ◽  
Racheal Angom ◽  
Hannington Baluku ◽  
Henry Kajumbula ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Bacterial Contamination ◽  
Sub Saharan Africa ◽  
Transfusion Therapy ◽  
Sub Saharan ◽  
Transfusion Reactions

Apheresis technology correlates with bacterial contamination of platelets and reported septic transfusion reactions

Transfusion ◽  
2017 ◽  
Vol 57 (12) ◽  
pp. 2969-2976 ◽  
Author(s):  
Anne F. Eder ◽  
Beth A. Dy ◽  
Barbara DeMerse ◽  
Stephen J. Wagner ◽  
Susan L. Stramer ◽  
...  
Keyword(s):  
Bacterial Contamination ◽  
Transfusion Reactions

Removal of biologic response modifiers associated with platelet transfusion reactions: strategies worth considering?

Transfusion ◽  
2014 ◽  
Vol 54 (10) ◽  
pp. 2583-2583 ◽  
Author(s):  
Olivier Garraud ◽  
Fabrice Cognasse ◽  
Hind Hamzeh-Cognasse ◽  
Sherry Spinelli ◽  
Richard P. Phipps ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Biologic Response ◽  
Transfusion Reactions

Effect of premedication guidelines and leukoreduction on the rate of febrile nonhaemolytic platelet transfusion reactions

2000 ◽  
Vol 10 (3) ◽  
pp. 199-206 ◽  
Author(s):  
Patterson ◽  
Freedman ◽  
Blanchette ◽  
Sher ◽  
Pinkerton ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Transfusion Reactions

scholarly journals Hazards of Bacterial Contamination of Blood Products

1993 ◽  
Vol 21 (1) ◽  
pp. 20-23 ◽  
Author(s):  
T. Gottlieb
Keyword(s):  
Bacterial Contamination ◽  
Skin Surface ◽  
Blood Products ◽  
Gram Positive ◽  
Viral Pathogens ◽  
Gram Negative ◽  
Safe Blood ◽  
The Third World ◽  
Collection Practice ◽  
Transfusion Reactions

Post-transfusion bacterial sepsis is infrequent. It is, however, associated with a high mortality due to septic shock. This reflects the release of endotoxin from gram negative bacteria. Lesser transfusion reactions are usually under-reported. These are frequently caused by gram positive bacteria. Gram positive species such as staphylococci and other skin surface organisms may be cultured from platelets stored at room temperature. Typically, gram negative “psychrophyllic” species which survive storage at 4°C are cultured from stored refrigerated blood implicated in transfusion reactions. These include Yersinia enterocolitica, Pseudomonas fluorescens etc. Bacterial contamination of the blood supply can occur via an endogenous or an exogenous source. Endogenous donor bacteraemia due to Y.enterocolitica may be asymptomatic or may follow an episode of gastroenteritis. Exogenous infections occur through some defect in the usual collection practice. Transfusion-acquired syphilis is now extremely uncommon. In the third world, beside the need for effective screening for viral pathogens, infections with protozoa, in particular plasmodia, trypanosoma and leishmania remain a major obstacle to ensuring safe blood supplies. Prevention of transfusion reactions demands rigorous attention to details of collection, storage, reissuing and infusion of blood products, as well as prompt treatment, testing and reporting of suspected reactions.

scholarly journals A method to estimate the incidence of transfusion reactions for transfusion-treated diseases in Chinese hospitals

2020 ◽  
Author(s):  
Feng Lin ◽  
Xue Tian ◽  
Yonghua Yin ◽  
Zhong Liu
Keyword(s):  
Lower Bound ◽  
Association Rule ◽  
Association Rule Mining ◽  
Platelet Transfusion ◽  
Rule Mining ◽  
Mining Algorithm ◽  
Icd 10 ◽  
Life Threatening ◽  
Transfusion Reactions ◽  
Platelet Transfusions

AbstractAlthough transfusion reactions are directly related to transfusion components, transfusion components are clinically related to the diseases afflicting patients. As some transfusion reactions can be life-threatening, estimating the incidence of transfusion reactions (which, in this study, are strictly defined as allergic and febrile non-haemolytic transfusion reactions) of certain categories of diseases is helpful for clinicians. According to the reported blood use of specific departments, the numbers of transfusion patients in these departments can be estimated. By the Association rule mining algorithm, the categories of diseases that often correlate with transfusion reactions have been screened for. It is found that the diseases belonging to C00-C97, D00-D48, D50-D89, K00-K93, N00-N99 and O00-O99 (ICD-10) often correlate with transfusion reactions. Platelet transfusion patients whose diseases belong to C00-C97 encounter transfusion reactions with an incidence of about 1%, which is much higher than the average. The incidence of transfusion reactions in patients whose diseases belong to K00-K93 –who undergo plasma transfusions –might be higher than the average, as the lower bound of this incidence is equivalent to the average incidence. Based on this study, it is suggested that attention be paid to patients whose diseases belong to C00-C97 –who undergo platelet transfusions –to prevent them from experiencing allergic transfusion reactions.

Single-donor platelets reduce the risk of septic platelet transfusion reactions

Transfusion ◽  
2001 ◽  
Vol 41 (7) ◽  
pp. 857-861 ◽  
Author(s):  
Paul Ness ◽  
Hayden Braine ◽  
Karen King ◽  
Christine Barrasso ◽  
Thomas Kickler ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Single Donor ◽  
Transfusion Reactions

scholarly journals CD40 ligand (CD154) involvement in platelet transfusion reactions

2012 ◽  
Vol 19 (3) ◽  
pp. 98-103 ◽  
Author(s):  
J. Sahler ◽  
S. Spinelli ◽  
R. Phipps ◽  
N. Blumberg
Keyword(s):  
Platelet Transfusion ◽  
Cd40 Ligand ◽  
Transfusion Reactions
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