Establishment of normal reference intervals in dogs using a viscoelastic point‐of‐care coagulation monitor and its comparison with thromboelastography

2020 ◽  
Author(s):  
Yekaterina Buriko ◽  
Kenneth Drobatz ◽  
Deborah C. Silverstein
Keyword(s):  
Point Of Care ◽  
Reference Intervals ◽  
Normal Reference

Assessment of the Size and Shape of the 4-Chamber View and the Right and Left Ventricles using Fetal Speckle Tracking in Normal Fetuses at 17-24 Gestational Weeks

2021 ◽  
Author(s):  
Sanitra Anuwutnavin ◽  
Kusol Russameecharoen ◽  
Pornpimol Ruangvutilert ◽  
Sommai Viboonchard ◽  
Mark Sklansky ◽  
...  
Keyword(s):  
Speckle Tracking ◽  
Fetal Heart ◽  
Reference Intervals ◽  
Reference Ranges ◽  
Z Score ◽  
Size And Shape ◽  
Chamber View ◽  
Normal Reference ◽  
Length Width ◽  
The Right

Introduction: The aim of the study was to establish normal reference values obtained by fetal speckle tracking analysis of the fetal heart between 17-24 weeks of gestation among Thai fetuses and compare the nomograms with previous studies. Methods: The 4-chamber view of the fetal heart in 79 normal fetuses was analyzed by speckle tracking analysis to determine the best-fit regression model. The 95% reference intervals and Z-score equations of fetal cardiac parameters were computed. Results: The end-diastolic length, width, area, and circumference of the 4-chamber view (4CV) as well as the ventricular end-diastolic length, 24-segment widths, and area were all increased as a function of gestational age (GA) and 5 fetal biometric parameters. In contrast, the global sphericity index (SI), 24-segment SI, and right ventricle/left ventricle width and area ratios did not change with GA or fetal biometric measurements. There were few differences in Z-score reference ranges of fetal cardiac measurements between the current study and previous studies conducted in different patient populations. Conclusion: Our study provided z-score and corresponding centile calculators, 5th and 95th centile reference tables, and corresponding graphs for evaluating the size and shape of the 4CV and the right and left ventricles using 6 independent variables between 17 and 24 weeks of gestation. These results provide normal reference ranges for future studies of fetuses with pathologies that may alter the size and shape of the 4-chamber view and ventricles.

Reference intervals for coagulation times using two point-of-care analysers in healthy pet rabbits (Oryctolagus cuniculus)

2014 ◽  
Vol 174 (26) ◽  
pp. 658-658 ◽  
Author(s):  
V. Mentré ◽  
C. Bulliot ◽  
A. Linsart ◽  
P. Ronot
Keyword(s):  
Oryctolagus Cuniculus ◽  
Point Of Care ◽  
Reference Intervals

Automated kinetic assay of angiotensin-converting enzyme in serum.

1986 ◽  
Vol 32 (5) ◽  
pp. 884-886 ◽  
Author(s):  
B Beneteau ◽  
B Baudin ◽  
G Morgant ◽  
J Giboudeau ◽  
F C Baumann
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Oral Contraceptives ◽  
Kinetic Method ◽  
Reference Intervals ◽  
Converting Enzyme ◽  
Kinetic Assay ◽  
Reaction Conditions ◽  
Normal Reference ◽  
Analytical Reliability ◽  
Normal Adults

Abstract We have developed and validated an automated kinetic method for angiotensin-converting enzyme (EC 3.4.15.1) on the Olli C + D analyzer, modified from that of Ronca-Testoni (Clin Chem 1983;29:1093-6) with N-[3-(2-furyl)-acryloyl]-L-phenylalanylglycylglycine used as substrate. We have determined appropriate reaction conditions for the assay, verified the principal analytical reliability criteria (repeatability, reproducibility, sensitivity), and established normal reference intervals (mean +/- SD) for the enzyme's activity, using serum of normal adults (100 +/- 35 U/L, n = 150), newborns (130 +/- 27 U/L, n = 10), women taking oral contraceptives (103 +/- 30 U/L, n = 10), smokers (109 +/- 38 U/L, n = 27), and patients with sarcoidosis (220 +/- 48 U/L, n = 15).

scholarly journals Establishment of Normal Reference Intervals for CD3+, CD4+, CD8+, and CD4+to CD8+Ratio of T Lymphocytes in HIV Negative Adults from University of Gondar Hospital, North West Ethiopia

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Addisu Gize ◽  
Biniam Mathewos ◽  
Beyene Moges ◽  
Meseret Workineh ◽  
Lealem Gedefaw
Keyword(s):  
T Lymphocytes ◽  
T Lymphocyte ◽  
Lymphocyte Subsets ◽  
Reference Interval ◽  
Reference Intervals ◽  
University Hospital ◽  
T Lymphocyte Subsets ◽  
Cross Sectional ◽  
North West ◽  
Normal Reference

Background.Reference values for the CD3+, CD4+, CD8+, and CD4+to CD8+ratio T lymphocyte subsets are adopted from textbooks. But for appropriate diagnosis, treatment, and follow-up of patients, correct interpretations of the laboratory results from normal reference interval are mandatory. This study was, therefore, planned to establish normal reference interval for T lymphocytes subset count and CD4+to CD8+ratio.Methods.A cross-sectional study was conducted on apparently healthy adult individuals who visited voluntary counseling and HIV testing clinic Gondar University Hospital from April to May, 2013. Whole blood was analyzed using fluorescence-activated cell sorting (BD FACS, San Jose, CA) machine to enumerate the T-cell subpopulations.Results.Out of the total 320 study participants, 161 (50.3%) were men and 159 (49.7%) were women. The normal reference intervals were (655–2,823 cells/μL), (321–1,389 cells/μL), and (220–1,664 cells/μL) for CD3+, CD4+, and CD8+T lymphocyte subsets, respectively, and CD4+to CD8+ratio was 0.5–2.5.Conclusion.The overall CD3+T lymphocytes reference interval in the current study was wide; low CD4+T lymphocytes, CD4 to CD8 ratio, and high CD8+T lymphocytes values were observed.

Normal reference interval for thyrotropin response to thyroliberin: dependence on age, sex, free thyroxin index, and basal concentrations of thyrotropin.

1984 ◽  
Vol 30 (2) ◽  
pp. 196-199 ◽  
Author(s):  
E M Erfurth ◽  
N E Nordén ◽  
P Hedner ◽  
A Nilsson ◽  
L Ek
Keyword(s):  
Linear Regression Analysis ◽  
Reference Interval ◽  
Multiple Linear Regression Analysis ◽  
Reference Intervals ◽  
Multivariate Statistical Methods ◽  
Individual Values ◽  
Multivariate Statistical ◽  
Normal Reference ◽  
Age Related ◽  
Basal Concentration

Abstract We measured the thyrotropin response (delta TSH) to 200 micrograms of thyroliberin in 131 subjects without thyroid dysfunction or other disease and with basal values for thyroid function that were within the normal reference intervals for our laboratory. By univariate and multivariate statistical methods we found delta TSH to be significantly influenced by the basal concentration of thyrotropin (TSH0) and the free thyroxin index (FT4I). When the effects of variations in TSH0 and FT4I were eliminated, delta TSH in men under 40 years of age did not differ from that in women. A decrease in delta TSH with increasing age was found in men but not in women. Thus a reference interval for delta TSH should consider TSH0, FT4I, and, in men, age. On the basis of multiple linear regression analysis, we constructed a formula for delta TSH reference intervals that takes into account individual values for TSH0 and FT4I. The formula should be applicable for women, regardless of age, up to 77 years and for men under 40 years. For older men a correction for the age-related decrease in delta TSH must be applied.

Comparison of serum and plasma SDMA measured with point-of-care and reference laboratory analysers: implications for interpretation of SDMA in cats

2021 ◽  
pp. 1098612X2098326
Author(s):  
Randolph M Baral ◽  
Kathleen P Freeman ◽  
Bente Flatland
Keyword(s):  
Point Of Care ◽  
Total Error ◽  
Clinical Results ◽  
Reference Intervals ◽  
Clinical Samples ◽  
Performance Goals ◽  
Specific Reference ◽  
Reference Laboratory ◽  
Laboratory Equipment ◽  
Commercial Laboratory

Objectives Symmetric dimethylarginine (SDMA) reflects the glomerular filtration rate (GFR) in people, dogs and cats. Initial assays used a liquid chromatography-mass spectroscopy (LC-MS) technique. A veterinary immunoassay has been developed for use in commercial laboratories and point-of-care (POC) laboratory equipment. This study sought to: determine POC and commercial laboratory (CL) SDMA assay imprecision; determine any bias of the POC assay compared with the CL assay; calculate observed total error of the POC assay and compare with analytical performance goals; and calculate dispersion and sigma metrics (σ) for POC and CL SDMA methods. Methods Two separate studies were performed that assessed: (1) imprecision, determined by evaluation of pooled feline plasma or serum; and (2) bias, assessed by comparing pooled plasma and serum results, as well as paired analyses of clinical samples from a single venepuncture measured using both analysers. Results were assessed in relation to performance goals. Dispersion and σ were calculated for both analysers. Results Bias between CL and POC analysers was consistent and high numbers of clinical results were outside performance goals across both studies. Imprecision was poor for both analysers for study 1 and improved to within quality goals for the CL analyser for study 2. Dispersion was at least 40%, meaning a measured result of 14 μg/dl represents a range of possible results from 8 μg/dl to 20 μg/dl. Conclusions and relevance Clinicians should be careful ascribing medical significance to small changes in SDMA concentration, as these may reflect analytical and biological variability. Analyser-specific reference intervals are likely required.

scholarly journals Establishment of normal reference intervals in serum biochemical parameters of domestic sows in Korea

2021 ◽  
Vol 36 (4) ◽  
pp. 261-269
Author(s):  
Dongyub Kim ◽  
Hwan-Deuk Kim ◽  
Youngmin Son ◽  
Sungho Kim ◽  
Min Jang ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Reference Intervals ◽  
Serum Biochemical Parameters ◽  
Normal Reference ◽  
Serum Biochemical
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