Extracorporeal photopheresis in solid organ transplant-associated acute graft-versus-host disease

Transfusion ◽  
2016 ◽  
Vol 56 (4) ◽  
pp. 962-969 ◽  
Author(s):  
Brett L. Houston ◽  
Matthew Yan ◽  
Kathryn Tinckam ◽  
Suzanne Kamel-Reid ◽  
Hong Chang ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Extracorporeal Photopheresis ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft

scholarly journals Graft Versus Host Disease

1970 ◽  
Vol 11 (2) ◽  
Author(s):  
Janeve Desy MD ◽  
Marc Deschenes MD
Keyword(s):  
Liver Transplantation ◽  
Graft Versus Host Disease ◽  
Rare Complication ◽  
Organ Transplant ◽  
Maculopapular Rash ◽  
Solid Organ Transplant ◽  
Hla Typing ◽  
Solid Organ ◽  
Host Disease ◽  
Graft Versus Host

Graft Versus Host Disease (GVHD) is a rare complication of liver transplantation with a mortality rate exceeding 65%. A 53-year-old male presented with a diffuse maculopapular rash, diarrhea, lymphopenia, fever, and confusion 14 days after orthotopic liver transplantation for hepatitis B cirrhosis. Skin biopsy and HLA- typing of peripheral blood confirmed a diagnosis of solid organ transplant related GVHD. This report summarizes what is known about this disease and emphasizes the importance of early diagnosis, which is one of the only factors known to improve the mortality of this deadly condition.

Solid Organ Transplant-Associated Acute Graft-Versus-Host Disease

2010 ◽  
Vol 134 (8) ◽  
pp. 1220-1224 ◽  
Author(s):  
Yaxia Zhang ◽  
Phillip Ruiz
Keyword(s):  
Bone Marrow ◽  
Graft Versus Host Disease ◽  
Clinical Symptoms ◽  
Bone Marrow Failure ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Multisystem Disease ◽  
Host Disease ◽  
Graft Versus Host

Abstract Solid organ transplant–associated graft-versus-host disease is an infrequent and potentially lethal complication. The incidence of this complication varies according to the type of organ transplant with higher rates associated with liver and small bowel transplants. The clinical presentation typically includes fever and skin rash, and most cases quickly advance to become a multisystem disease affecting the bone marrow and other nontransplanted solid organs. The diagnosis is based on the clinical symptoms, pathologic changes in biopsied tissues, and systemic lymphoid chimerism. The mortality of this disease can exceed 75% after liver transplant and most patients die from infections or hemorrhage due to bone marrow failure. There is no standard treatment strategy for this complication, and the management mainly consists of both prophylaxis and immediate treatment without delay. This short review summarizes the current pathogenesis, diagnosis, and treatment of this entity.

scholarly journals Mortality Predictors in Solid Organ Transplant Associated Graft Versus Host Disease. Single Center Experience

2021 ◽  
Vol 27 (3) ◽  
pp. S279-S280
Author(s):  
Nino Balanchivadze ◽  
Muhammad Shahid ◽  
Julia Bachler ◽  
George Divine ◽  
Kylie Springer ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Single Center ◽  
Host Disease ◽  
Graft Versus Host ◽  
Single Center Experience ◽  
Mortality Predictors

scholarly journals Outcomes of Extracorporeal Photopheresis (ECP) in Treatment of Severe Acute Graft-Versus-Host Disease (aGvHD)

2021 ◽  
Vol 27 (3) ◽  
pp. S297-S298
Author(s):  
Zachary J Sebghati ◽  
Haitham Abdelhakim ◽  
Anurag K Singh ◽  
Leyla Shune ◽  
Siddhartha Ganguly ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Extracorporeal Photopheresis ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft

scholarly journals Experience with the Use of Infliximab and/or Extracorporeal Photopheresis in Steroid-Refractory Acute Graft Versus Host Disease

2018 ◽  
Vol 24 (3) ◽  
pp. S194 ◽  
Author(s):  
Marietta Nygaard ◽  
Tonny Karlsmark ◽  
Niels Smedegaard ◽  
Ida Schjødt ◽  
Lone S. Friis ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Extracorporeal Photopheresis ◽  
Host Disease ◽  
Graft Versus Host ◽  
Steroid Refractory ◽  
Acute Graft
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