scholarly journals Graft-Versus-Host Disease after Solid Organ Transplant Is Frequently Associated with Bone Marrow Failure and Hemophagocytosis

2020 ◽  
Vol 26 (3) ◽  
pp. S194
Author(s):  
Laura F. Newell ◽  
Jennifer B. Dunlap ◽  
Ken Gatter ◽  
Richard Press ◽  
Guang Fan ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Graft Versus Host Disease ◽  
Bone Marrow Failure ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Host Disease ◽  
Graft Versus Host

Solid Organ Transplant-Associated Acute Graft-Versus-Host Disease

2010 ◽  
Vol 134 (8) ◽  
pp. 1220-1224 ◽  
Author(s):  
Yaxia Zhang ◽  
Phillip Ruiz
Keyword(s):  
Bone Marrow ◽  
Graft Versus Host Disease ◽  
Clinical Symptoms ◽  
Bone Marrow Failure ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Multisystem Disease ◽  
Host Disease ◽  
Graft Versus Host

Abstract Solid organ transplant–associated graft-versus-host disease is an infrequent and potentially lethal complication. The incidence of this complication varies according to the type of organ transplant with higher rates associated with liver and small bowel transplants. The clinical presentation typically includes fever and skin rash, and most cases quickly advance to become a multisystem disease affecting the bone marrow and other nontransplanted solid organs. The diagnosis is based on the clinical symptoms, pathologic changes in biopsied tissues, and systemic lymphoid chimerism. The mortality of this disease can exceed 75% after liver transplant and most patients die from infections or hemorrhage due to bone marrow failure. There is no standard treatment strategy for this complication, and the management mainly consists of both prophylaxis and immediate treatment without delay. This short review summarizes the current pathogenesis, diagnosis, and treatment of this entity.

scholarly journals Graft Versus Host Disease

1970 ◽  
Vol 11 (2) ◽  
Author(s):  
Janeve Desy MD ◽  
Marc Deschenes MD
Keyword(s):  
Liver Transplantation ◽  
Graft Versus Host Disease ◽  
Rare Complication ◽  
Organ Transplant ◽  
Maculopapular Rash ◽  
Solid Organ Transplant ◽  
Hla Typing ◽  
Solid Organ ◽  
Host Disease ◽  
Graft Versus Host

Graft Versus Host Disease (GVHD) is a rare complication of liver transplantation with a mortality rate exceeding 65%. A 53-year-old male presented with a diffuse maculopapular rash, diarrhea, lymphopenia, fever, and confusion 14 days after orthotopic liver transplantation for hepatitis B cirrhosis. Skin biopsy and HLA- typing of peripheral blood confirmed a diagnosis of solid organ transplant related GVHD. This report summarizes what is known about this disease and emphasizes the importance of early diagnosis, which is one of the only factors known to improve the mortality of this deadly condition.

Extracorporeal photopheresis in solid organ transplant-associated acute graft-versus-host disease

Transfusion ◽  
2016 ◽  
Vol 56 (4) ◽  
pp. 962-969 ◽  
Author(s):  
Brett L. Houston ◽  
Matthew Yan ◽  
Kathryn Tinckam ◽  
Suzanne Kamel-Reid ◽  
Hong Chang ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Extracorporeal Photopheresis ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft

scholarly journals Mortality Predictors in Solid Organ Transplant Associated Graft Versus Host Disease. Single Center Experience

2021 ◽  
Vol 27 (3) ◽  
pp. S279-S280
Author(s):  
Nino Balanchivadze ◽  
Muhammad Shahid ◽  
Julia Bachler ◽  
George Divine ◽  
Kylie Springer ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Single Center ◽  
Host Disease ◽  
Graft Versus Host ◽  
Single Center Experience ◽  
Mortality Predictors

scholarly journals Skin-Limited Graft-versus-Host Disease after Pancreatic Transplantation

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Muneeb Ilyas ◽  
Elika Hoss ◽  
David J. DiCaudo ◽  
Hasan Khamash ◽  
Mark R. Pittelkow ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Organ Transplant ◽  
Organ Transplant Recipient ◽  
Solid Organ Transplant Recipient ◽  
Solid Organ ◽  
Pancreatic Transplantation ◽  
Case Presentation ◽  
Host Disease ◽  
Graft Versus Host

Introduction. The phenomenon of graft-versus-host disease, a solid organ transplant recipient, is a rare development with a very poor prognosis. Case Presentation. A 40-year-old woman with type 1 diabetes developed cutaneous graft-versus-host disease following second pancreas transplantation. Conclusion. The development of a nonspecific rash in the early posttransplant period following a pancreas transplant warrants suspicion for graft-versus-host disease.

scholarly journals Small bowel necrosis and perforation due to sodium polystyrene sulfonate in the setting of graft versus host disease and fulminant Clostridium difficile infection

2020 ◽  
Vol 2020 (8) ◽  
Author(s):  
Leah Sukri ◽  
Laura DiChiacchio ◽  
Philip J Wasicek ◽  
Stephen M Kavic
Keyword(s):  
Small Bowel ◽  
Clostridium Difficile ◽  
Graft Versus Host Disease ◽  
Organ Transplant ◽  
Common Adverse Event ◽  
Sodium Polystyrene Sulfonate ◽  
Solid Organ ◽  
Polystyrene Sulfonate ◽  
Host Disease ◽  
Graft Versus Host

Abstract Gastrointestinal injury is a common adverse event associated with use of sodium polystyrene sulfonate (SPS), tradename Kayexalate. Risk factors for SPS-mediated gastrointestinal necrosis include chronic kidney disease, solid organ transplant recipiency and recent surgery. This report presents a patient with past medical history significant for acute myeloid leukemia (AML) complicated by graft versus host disease (GvHD) and Clostridium difficile colitis who initially presented with small bowel obstruction. She was taken to the operating room and her small bowel pathology was significant for transmural necrosis with SPS crystals in the granulation tissue, despite last receiving SPS over a year ago. Previous mucosal damage should be considered as a risk factor for SPS-mediated injury and the effects of this medication may occur longer than previously thought.

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