Histopathologic and immunophenotypic features of cutaneous solid organ transplant‐associated graft‐versus‐host disease: Comparison with acute hematopoietic cell transplant‐associated graft‐versus‐host disease and cutaneous drug eruption

2021 ◽  
Author(s):  
Aaron J. Russell ◽  
Amy C. Musiek ◽  
Karl W. Staser ◽  
Ilana S. Rosman
Keyword(s):  
Graft Versus Host Disease ◽  
Drug Eruption ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Hematopoietic Cell ◽  
Solid Organ ◽  
Cell Transplant ◽  
Hematopoietic Cell Transplant ◽  
Host Disease ◽  
Graft Versus Host

scholarly journals The Impact of Graft-Versus-Host Disease on Survival in Children with Non-Malignant Disorders Receiving Allogeneic Hematopoietic Cell Transplant

2021 ◽  
Author(s):  
Biljana Horn ◽  
Paul Castillo ◽  
Mustafa Hanif ◽  
Jorge GalvezSilva ◽  
Edward Ziga ◽  
...  
Keyword(s):  
Risk Factors ◽  
Graft Versus Host Disease ◽  
Survival Rates ◽  
Hematopoietic Cell ◽  
Cell Transplant ◽  
Hematopoietic Cell Transplant ◽  
Host Disease ◽  
Graft Versus Host ◽  
The Impact ◽  
Grade Iii

Abstract Background: Graft-versus-host disease (GVHD) is a common and undesirable complication of hematopoietic cell transplant (HCT) for non-malignant disorders (NMD). Understanding the incidence and risk factors for GVHD in children with NMD is an important step in developing strategies for its prevention. Study Design: This is a retrospective, registry, study that included children with NMD receiving HCT in 5 centers in Florida between 2010 and 2019. Results: Among 183 patients evaluable for GVHD, acute GVHD (aGVHD) grades I, II, III, and IV were present in 18%, 12.6%, 3.8% and 5.5% of patients, respectively. Limited and extensive chronic GVHD (cGVHD), were observed in 8.7% and 12.6% of patients. Patients with aGVHD grade III/IV had significantly lower 3-year survival rates than those without aGVHD, or those with aGVHD grade I/II (52.9% [95% confidence interval (CI) 34-83] vs. 90.1% [95% CI 84-96], vs. 98.1% [95%CI 95-100], p<0.001). Patients without cGVHD and those with limited and extensive cGVHD had 3-year survival rates of 88.9% [95%CI 84-94], 91.7% [95%CI 77-100], and 84.8% [95%CI 70-100], respectively, log rank p=0.3. Receiving transplant from an HLA-mismatched unrelated donor (MMUD), as compared to a matched related donor (MRD), increased the risk for aGVHD grade III/IV (Odds ratio 10.4 [95% CI 2.5-47.6]). There were no cases of aGVHD grade III/IV among recipients of mismatched related/haploidentical transplants. Conclusions: Grade III/IV aGVHD, which significantly reduced overall survival, was reported in 9.3% of children with NMD receiving HCT. Risk factors included HCT from a MMUD but not mismatched related donors.

scholarly journals Graft Versus Host Disease

1970 ◽  
Vol 11 (2) ◽  
Author(s):  
Janeve Desy MD ◽  
Marc Deschenes MD
Keyword(s):  
Liver Transplantation ◽  
Graft Versus Host Disease ◽  
Rare Complication ◽  
Organ Transplant ◽  
Maculopapular Rash ◽  
Solid Organ Transplant ◽  
Hla Typing ◽  
Solid Organ ◽  
Host Disease ◽  
Graft Versus Host

Graft Versus Host Disease (GVHD) is a rare complication of liver transplantation with a mortality rate exceeding 65%. A 53-year-old male presented with a diffuse maculopapular rash, diarrhea, lymphopenia, fever, and confusion 14 days after orthotopic liver transplantation for hepatitis B cirrhosis. Skin biopsy and HLA- typing of peripheral blood confirmed a diagnosis of solid organ transplant related GVHD. This report summarizes what is known about this disease and emphasizes the importance of early diagnosis, which is one of the only factors known to improve the mortality of this deadly condition.

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