scholarly journals Screening of at‐risk blood donors for Chagas disease in non‐endemic countries: Lessons from a 2‐year experience in Tuscany, Italy

2020 ◽  
Author(s):  
Valentina D. Mangano ◽  
Marco Prato ◽  
Antonella Marvelli ◽  
Giovanna Moscato ◽  
Fabrizio Bruschi
Keyword(s):  
At Risk ◽  
Chagas Disease ◽  
Blood Donors

scholarly journals Treatment of T. cruzi infected human platelet concentrates with aminomethyltrimethyl psoralen (AMT) and ultravioleta (UV-A) light: preliminary results

1996 ◽  
Vol 29 (1) ◽  
pp. 47-49 ◽  
Author(s):  
Hélio Moraes-Souza ◽  
José Orlando Bordin ◽  
Leslie Bardossy ◽  
Morris A. Blajchman
Keyword(s):  
Ascorbic Acid ◽  
Chagas Disease ◽  
Untreated Control ◽  
Blood Donors ◽  
Human Platelet ◽  
Gentian Violet ◽  
Platelet Concentrates ◽  
Preliminary Results ◽  
Combined Use

The present measures adopted to prevent transfusion-associated Chagas' disease include screening of blood donors. and/or the inactivation of T. cruzi in collected blood using gentian violet (GV) as a trypanocidal agent. In this study, we investigated the efficacy of the combined use of AMT and UV-A in inactirating T. cruzi in infected human platelet cuncentrates. Human platelet concentrates were infected with T. cruzi (2x10/ml) of the Y strain transfered to PL 269 (Fenwal Laboratories) containers and treated with GV (250řg,/ml). and ascorbic acid (1 mg/ml); GV. ascorbic acid and UV-A; GV and UV-A; AMT (40/tG/ml) and ascorbic acid; AMT, ascorbic acid and UV-A; AMT and UV-A; UV-A alone; and untreated (control). All UV-A treated platelet concentrates were exposed to UV-A doses of 24, 92, 184, 276, 368 and 644 kj/m². and the microscopical research of active T. cruzi was performed, using the microhematocrit technique, 1, 6 and 24 hours after each treatment. A high number of active forms of T. cruzi was observed in all condictions, except when GV was used as the trypanocidal agent, providing evidence of the failure of AMT and UV-A in inactivating T cruzi in infected human platelet concentrates.

scholarly journals SEROPREVALENCE OF CHAGASIC INFECTION IN YOUNG INDIVIDUALS IN A BLOOD CENTER IN THE STATE OF SAO PAULO, BRAZIL

2013 ◽  
Vol 55 (4) ◽  
pp. 245-250 ◽  
Author(s):  
Elaine Cristina Navarro ◽  
Renata Leme Goto ◽  
Isabella Silva Ricoboni ◽  
Jose Eduardo Corrente ◽  
Rita Maria Saccomano Henriques ◽  
...  
Keyword(s):  
Public Health ◽  
Chagas Disease ◽  
Blood Donors ◽  
Public Health Problem ◽  
Sao Paulo ◽  
São Paulo ◽  
Blood Center ◽  
Negative Results ◽  
Central Regions ◽  
The City

SUMMARY This study aimed at estimating the number of cases of non-negative serological reactions to Chagas disease in blood donors at the Blood Center of Botucatu, São Paulo, Brazil, from 2003 to 2010 and at relating them to their cities of origin. Five hundred and seventy-four non-negative results for Chagas disease were evaluated. Of these, 371 (64.8%) were reagent, and 203 (35.4%) were inconclusive. The prevalence of Chagas disease in blood donors was 0.05%. There were, on average, 72 cases/year, and a prevalence of males was observed (64.8%). Forty-three (7.49%) individuals were 18 to 30 years old; 92 (16.02%) were 31 to 40; 147 (25.61%) 41 to 50, and 292 (50.87%) were older than 50 years. It was observed that 29.3% of females with reagent serology were at their fertile age (18 and 45 years). The majority of donors were originally from cities in the southwestern and central regions of São Paulo, but individuals from other states contributed with 20%. The provenance of most donors was the city of Botucatu/SP, followed by the city of Taquarituba/SP. Therefore, the profile of donors at this blood center favors the occurrence of a larger number of non-negative serological reactions. Although there has been a significant reduction in the number of new cases/year for this disease, it is still a public-health problem, and results suggest the need for new epidemiological assessments in the studied region.

BLOOD DONORS AND BLOOD COLLECTION: Testing blood donors for Chagas disease in the Paris area, France: first results after 18 months of screening

Transfusion ◽  
2009 ◽  
Vol 50 (3) ◽  
pp. 575-583 ◽  
Author(s):  
Marie-Hélène El Ghouzzi ◽  
Elisabeth Boiret ◽  
Françoise Wind ◽  
Claudine Brochard ◽  
Sébastien Fittere ◽  
...  
Keyword(s):  
Chagas Disease ◽  
Blood Donors ◽  
Blood Collection ◽  
Paris Area ◽  
First Results

scholarly journals Prevalence of Chagas disease in blood donors at the Uberaba Regional Blood Center, Brazil, from 1995 to 2009

2012 ◽  
Vol 45 (6) ◽  
pp. 723-726 ◽  
Author(s):  
Laryssa Manso de Lima ◽  
Nathália Passos Alves ◽  
Valdirene de Fátima Barbosa ◽  
Gustavo Alves Pimenta ◽  
Helio Moraes-Souza ◽  
...  
Keyword(s):  
Chagas Disease ◽  
Blood Donors ◽  
Retrospective Studies ◽  
Chi Square ◽  
Significant Drop ◽  
Blood Center ◽  
Epidemiologic Profile ◽  
Chi Square Test ◽  
Consistent Increase

INTRODUCTION: A retrospective study was conducted to assess the occurrence of blood donations that were ineligible due to Chagas disease infection from 1995 to 2009 at the Uberaba Regional Blood Center (HRU), Brazil, verify the tendency of this ineligibility, and describe the epidemiologic profile of the donors. METHODS: Retrospective studies of serological ineligibility due to Chagas disease, statistical analysis by means of the chi-square test and odds ratio, study of the tendencies using a dispersion graph and the linear correlation coefficient (r) were performed. RESULTS: In the period under study, a 0.2% serum prevalence of ineligibility due to Chagas disease was found, with a significant drop in ineligible donations from 2001 to 2009. Among the serum positive-donors, there was a significant predominance among those aged 30 years or above and non-single individuals. CONCLUSIONS: The results show a rate of occurrence that is lower than that described in literature, as well as a progressive drop during the 15 years under assessment. Such results are a consequence of systematic combat of the vector since the 70s and the progressive and consistent increase of returning donors, resulting in a drop of the contamination risk factor by means of blood transfusion and in the improvement of the quality of hemotherapy practices in the HRU.

scholarly journals Chagas disease: Performance analysis of immunodiagnostic tests anti-Trypanosoma cruzi in blood donors with inconclusive screening results

2020 ◽  
Author(s):  
Márcia M Ferreira-Silva ◽  
Gilberto de Araújo Pereira ◽  
Virmondes Rodrigues-Júnior ◽  
Wendell SF Meira ◽  
Fernando V Basques ◽  
...  
Keyword(s):  
Performance Analysis ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Blood Donors ◽  
Immunodiagnostic Tests

Use of a questionnaire to identify potential blood donors at risk for infection with Trypanosoma cruzi

Transfusion ◽  
1993 ◽  
Vol 33 (1) ◽  
pp. 61-64 ◽  
Author(s):  
MD Appleman ◽  
IA Shulman ◽  
S Saxena ◽  
LV Kirchhoff
Keyword(s):  
At Risk ◽  
Trypanosoma Cruzi ◽  
Blood Donors

Seroprevalence ofTrypanosoma cruziinfection in at-risk blood donors in Catalonia (Spain)

Transfusion ◽  
2008 ◽  
Vol 48 (9) ◽  
pp. 1862-1868 ◽  
Author(s):  
Maria Piron ◽  
Mireia Vergés ◽  
José Muñoz ◽  
Natàlia Casamitjana ◽  
Sergi Sanz ◽  
...  
Keyword(s):  
At Risk ◽  
Blood Donors

scholarly journals Seroepidemiology ofTrypanosoma cruzi, Etiologic Agent of Chagas' Disease, in US Blood Donors

1997 ◽  
Vol 176 (4) ◽  
pp. 1047-1052 ◽  
Author(s):  
David A. Leiby ◽  
Elizabeth J. Read ◽  
Bruce A. Lenes ◽  
A. Jeffrey Yund ◽  
Robert J. Stumpf ◽  
...  
Keyword(s):  
Chagas Disease ◽  
Blood Donors ◽  
Etiologic Agent

Screening potential blood donors at risk for human immunodeficiency virus

Transfusion ◽  
1991 ◽  
Vol 31 (5) ◽  
pp. 466-474 ◽  
Author(s):  
DJ Mayo ◽  
AM Rose ◽  
SE Matchett ◽  
PA Hoppe ◽  
JM Solomon ◽  
...  
Keyword(s):  
At Risk ◽  
Human Immunodeficiency Virus ◽  
Blood Donors ◽  
Immunodeficiency Virus
Sign in / Sign up

Export Citation Format

Share Document