Transfusion reaction due toKlebsiella pneumoniae-contaminated red blood cells: a case report

2013 ◽  
Vol 23 (6) ◽  
pp. 445-446 ◽  
Author(s):  
P. Warnke ◽  
V. Kiefel ◽  
H. Schäffler ◽  
A. Podbielski
Keyword(s):  
Case Report ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Transfusion Reaction

A case study of a patient with anti-Yta alloantibodies against the high-prevalence antigen of red blood cells qualified for heart transplantation

2021 ◽  
Vol 56 (3) ◽  
pp. 1-7
Author(s):  
Monika Witoszek ◽  
Małgorzata Kalaga
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Blood Donation ◽  
Heart Diseases ◽  
Blood Group System ◽  
Transfusion Reaction ◽  
Indirect Antiglobulin Test ◽  
High Prevalence ◽  
Compatible Blood

The Yta antigen from the Cartwright blood group system is a high-prevalence antigen found in 99.8% of the population. The literature data shows that antibodies anti-Yta demonstrate the variable clinical significance and are rarely the cause of a hemolytic post-transfusion reaction. The study aims to present the difficulties related to the selection and sustainable supply of blood for transfusion for the patient of the Silesian Centre for Heart Diseases with anti-Yta alloantibodies, qualified for a heart transplant. If Yt(a-) blood is not available Institute of Hematology and Transfusion Medicine in Warsaw, referring to reports in the publications, allowed transfusion of the least incompatible red blood cells in indirect antiglobulin test. One hour after transfusion of leucocyte-depleted concentrate of red blood cells (RBCs), issued in accordance with the above recommendations by Regional Blood Donation Center in Katowice as the least incompatible, the patient was observed to experience symptoms of an adverse post-transfusion reaction. For subsequent transfusions, RBCs from Yt(a-) donors were selected, of which only eight were registered in Poland at that time. Medical decisions on RBCs transfusion in patients for whom no compatible blood can be selected is very difficult, and the benefits of incompatible transfusion should be weighed against the risk of possible complications. To avoid this, it should be remembered that the early identification of antibodies increases the chance of finding serologically compatible blood and in many cases allows to supply blood for a patient with autologous donations.

Retrospektywna analiza przypadku wzmożonej hemolizy u pacjentki z opóźnioną hemolityczną reakcją poprzetoczeniową spowodowaną przeciwciałami anty-K

2018 ◽  
Vol 21 (2) ◽  
Author(s):  
Bożena Andrys ◽  
Katarzyna Korybalska
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Genetic Disorders ◽  
Hematological Parameters ◽  
Transfusion Reaction ◽  
Ferritin Concentration ◽  
Packed Red Blood Cells ◽  
Human Red Blood Cells ◽  
Hemolytic Transfusion Reaction ◽  
Life Threatening

Hyperhemolysis is a life-threatening undesirable post-transfusion reaction characterized by a decrease in hemoglobin (Hb), hematocrit (Hct), reticulocytopenia and increase in ferritin concentration. It usually occurs in patients with hemoglobinopathies, rarely in people without genetic disorders of human red blood cells. The case concerns a 79-year-old woman who, due to a trophic ulcer and erysipelas, received one unit of kell positive packed red blood cells (pRBC). The patient did not exhibit symptoms of hypoxia despite the reduced value of hematological parameters (Hb: 10.4 g/dl, Hct: 31%). Delayed hemolytic transfusion reaction (DHTR) occurred after 11 days, with the presence of anti-K antibodies (Hb: 6.1 g/dl, Hct: 17%). Despite transfusion of three pRBC properly selected against patient’s antigens, only a transient increase in Hb and Hct was observed (Hb: 8.1 g/dl, Hct: 22%). These parameters rapidly decreased within 18 hours (Hb: 6.7 g/dl, Hct: 18%). The patient died due to circulatory and respiratory failure.

A Hemolytic Transfusion Reaction Caused by an Unexpected Leb Antibody

2021 ◽  
Author(s):  
Alexander A Delk ◽  
Richard R Gammon ◽  
Harold Alvarez ◽  
Nancy Benitez ◽  
Frieda Bright
Keyword(s):  
Sickle Cell Disease ◽  
Red Blood Cells ◽  
Black Male ◽  
Blood Cells ◽  
Reference Laboratory ◽  
Transfusion Reaction ◽  
Cell Disease ◽  
Hemolytic Transfusion Reaction ◽  
History Of ◽  
Possible Cause

Abstract A Black male patient aged 21 years with a history of sickle cell disease and HIV was admitted to the hospital with vaso-occlusive crisis. A transfusion reaction was called after the patient developed a fever (39.5°C), tachycardia, chills, and hematuria after receiving 300 mL of red blood cells. A posttransfusion specimen was submitted to the Immunohematology Reference Laboratory for investigation. Antibody identification revealed an anti-Leb as the probable cause of the immediate acute hemolytic transfusion reaction. Lewis antibodies are considered clinically insignificant. This case shows the importance of considering cold antibodies, including Lewis antibodies, as a possible cause of an acute hemolytic transfusion reaction.

scholarly journals Delayed Hemolytic Transfusion Reaction - A Case Report

2012 ◽  
Vol 4 (2) ◽  
pp. 15-19
Author(s):  
Rajay A. D. Kamath ◽  
Kiran V. Neswi ◽  
Shiva Bharani K.S.N. ◽  
M.A. Giri Sankar
Keyword(s):  
Case Report ◽  
Blood Transfusion ◽  
Blood Cells ◽  
Blood Transfusions ◽  
Transfusion Reaction ◽  
Blood Products ◽  
Hemolytic Transfusion Reaction ◽  
Delayed Hemolytic Transfusion Reaction ◽  
Cross Matching ◽  
Hematological Tests

Abstract Blood transfusion is the process of receiving blood products into one's circulation intravenously. Transfusions are used in a variety of medical conditions to replace lost components of the blood. Transfusions of blood products are associated with several complications, many of which can be grouped as immunological or infection. Acute hemolytic reactions occur with transfusion of red blood cells and are due to destruction of donor erythrocytes by preformed recipient antibodies. Most often this occurs due to clerical” errors or improper typing and cross matching. Delayed hemolytic reactions occur more frequently and are due to the same mechanism as in acute hemolytic reactions. However, the consequences are generally mild and a great proportion of patients may not have symptoms. However, evidence of hemolysis and falling hemoglobin levels may still occur. Treatment is generally not needed, but due to the presence of recipient antibodies, future compatibility may be affected. Hereby we share our experience of such a case of delayed hemolytic transfusion reaction and discussing the various measures to be taken during any such incidence and the biochemical and hematological tests to confirm the diagnosis.

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