Red cell exchange to mitigate a delayed hemolytic transfusion reaction in a patient transfused with incompatible red blood cells

2016 ◽  
Vol 32 (1) ◽  
pp. 59-61 ◽  
Author(s):  
Mehraboon S. Irani ◽  
Matthew S. Karafin ◽  
Luke Ernster
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Red Cell ◽  
Transfusion Reaction ◽  
Hemolytic Transfusion Reaction ◽  
Delayed Hemolytic Transfusion Reaction

Retrospektywna analiza przypadku wzmożonej hemolizy u pacjentki z opóźnioną hemolityczną reakcją poprzetoczeniową spowodowaną przeciwciałami anty-K

2018 ◽  
Vol 21 (2) ◽  
Author(s):  
Bożena Andrys ◽  
Katarzyna Korybalska
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Genetic Disorders ◽  
Hematological Parameters ◽  
Transfusion Reaction ◽  
Ferritin Concentration ◽  
Packed Red Blood Cells ◽  
Human Red Blood Cells ◽  
Hemolytic Transfusion Reaction ◽  
Life Threatening

Hyperhemolysis is a life-threatening undesirable post-transfusion reaction characterized by a decrease in hemoglobin (Hb), hematocrit (Hct), reticulocytopenia and increase in ferritin concentration. It usually occurs in patients with hemoglobinopathies, rarely in people without genetic disorders of human red blood cells. The case concerns a 79-year-old woman who, due to a trophic ulcer and erysipelas, received one unit of kell positive packed red blood cells (pRBC). The patient did not exhibit symptoms of hypoxia despite the reduced value of hematological parameters (Hb: 10.4 g/dl, Hct: 31%). Delayed hemolytic transfusion reaction (DHTR) occurred after 11 days, with the presence of anti-K antibodies (Hb: 6.1 g/dl, Hct: 17%). Despite transfusion of three pRBC properly selected against patient’s antigens, only a transient increase in Hb and Hct was observed (Hb: 8.1 g/dl, Hct: 22%). These parameters rapidly decreased within 18 hours (Hb: 6.7 g/dl, Hct: 18%). The patient died due to circulatory and respiratory failure.

A Hemolytic Transfusion Reaction Caused by an Unexpected Leb Antibody

2021 ◽  
Author(s):  
Alexander A Delk ◽  
Richard R Gammon ◽  
Harold Alvarez ◽  
Nancy Benitez ◽  
Frieda Bright
Keyword(s):  
Sickle Cell Disease ◽  
Red Blood Cells ◽  
Black Male ◽  
Blood Cells ◽  
Reference Laboratory ◽  
Transfusion Reaction ◽  
Cell Disease ◽  
Hemolytic Transfusion Reaction ◽  
History Of ◽  
Possible Cause

Abstract A Black male patient aged 21 years with a history of sickle cell disease and HIV was admitted to the hospital with vaso-occlusive crisis. A transfusion reaction was called after the patient developed a fever (39.5°C), tachycardia, chills, and hematuria after receiving 300 mL of red blood cells. A posttransfusion specimen was submitted to the Immunohematology Reference Laboratory for investigation. Antibody identification revealed an anti-Leb as the probable cause of the immediate acute hemolytic transfusion reaction. Lewis antibodies are considered clinically insignificant. This case shows the importance of considering cold antibodies, including Lewis antibodies, as a possible cause of an acute hemolytic transfusion reaction.

scholarly journals Delayed Hemolytic Transfusion Reaction - A Case Report

2012 ◽  
Vol 4 (2) ◽  
pp. 15-19
Author(s):  
Rajay A. D. Kamath ◽  
Kiran V. Neswi ◽  
Shiva Bharani K.S.N. ◽  
M.A. Giri Sankar
Keyword(s):  
Case Report ◽  
Blood Transfusion ◽  
Blood Cells ◽  
Blood Transfusions ◽  
Transfusion Reaction ◽  
Blood Products ◽  
Hemolytic Transfusion Reaction ◽  
Delayed Hemolytic Transfusion Reaction ◽  
Cross Matching ◽  
Hematological Tests

Abstract Blood transfusion is the process of receiving blood products into one's circulation intravenously. Transfusions are used in a variety of medical conditions to replace lost components of the blood. Transfusions of blood products are associated with several complications, many of which can be grouped as immunological or infection. Acute hemolytic reactions occur with transfusion of red blood cells and are due to destruction of donor erythrocytes by preformed recipient antibodies. Most often this occurs due to clerical” errors or improper typing and cross matching. Delayed hemolytic reactions occur more frequently and are due to the same mechanism as in acute hemolytic reactions. However, the consequences are generally mild and a great proportion of patients may not have symptoms. However, evidence of hemolysis and falling hemoglobin levels may still occur. Treatment is generally not needed, but due to the presence of recipient antibodies, future compatibility may be affected. Hereby we share our experience of such a case of delayed hemolytic transfusion reaction and discussing the various measures to be taken during any such incidence and the biochemical and hematological tests to confirm the diagnosis.

Colloid osmotic pressure changes of dog's blood exposed to different mixtures of CO2 and air

1978 ◽  
Vol 44 (2) ◽  
pp. 254-257 ◽  
Author(s):  
Y. Kakiuchi ◽  
A. B. DuBois ◽  
D. Gorenberg
Keyword(s):  
Red Blood Cells ◽  
Osmotic Pressure ◽  
Cell Volume ◽  
Blood Cells ◽  
Freezing Point ◽  
Colloid Osmotic Pressure ◽  
Red Cell ◽  
Freezing Point Depression ◽  
Pressure Changes ◽  
Different Levels

Hansen's membrane manometer method for measuring plasma colloid osmotic pressure was used to obtain the osmolality changes of dogs breathing different levels of CO2. Osmotic pressure was converted to osmolality by calibration of the manometer with saline and plasma, using freezing point depression osmometry. The addition of 10 vol% of CO2 to tonometered blood caused about a 2.0 mosmol/kg H2O increase of osmolality, or 1.2% increase of red blood cell volume. The swelling of the red blood cells was probably due to osmosis caused by Cl- exchanged for the HCO3- which was produced rapidly by carbonic anhydrase present in the red blood cells. The change in colloid osmotic pressure accompanying a change in co2 tension was measured on blood obtained from dogs breathing different CO2 mixtures. It was approximately 0.14 mosmol/kg H2O per Torr Pco2. The corresponding change in red cell volume could not be calculated from this because water can exchange between the plasma and tissues.

THE UNIQUE FETAL RED CELL AND ITS FUNCTION

PEDIATRICS ◽  
1973 ◽  
Vol 51 (3) ◽  
pp. 494-500 ◽  
Author(s):  
Frank A. Oski
Keyword(s):  
Red Blood Cells ◽  
Newborn Infant ◽  
Blood Cells ◽  
Human Fetus ◽  
Exchange Transfusion ◽  
Oxygen Atmosphere ◽  
Hypoxic Stress ◽  
Red Cell ◽  
Low Oxygen ◽  
Rapid Replacement

The red blood cells of the human fetus differ in many major respects from the red cells of the normal adult. These differences appear admirably suited for the acquisition, transport, and release of oxygen in the low oxygen atmosphere of intrauterine existence. These same differences appear to confer a handicap to the cell in the extrauterine environment, particularly under conditions of hypoxic stress. The rapid replacement of these cells by artificial means, such as early exchange transfusion, may offer an advantage to the newborn infant in certain clinical situations.

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