Reflectance confocal microscopy of Pigmented Bowen's disease: misleading dendritic cells

2016 ◽  
Vol 23 (1) ◽  
pp. 126-128 ◽  
Author(s):  
S. Debarbieux ◽  
J. L. Perrot ◽  
E. Cinotti ◽  
B. Labeille ◽  
J. Fontaine ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy ◽  
Bowen’S Disease ◽  
Bowen's Disease

scholarly journals Reflectance Confocal Microscopy of Pigmented Bowen’s Disease: A Case Series of Difficult to Diagnose Lesions

2020 ◽  
Vol 12 (2) ◽  
pp. 98-106
Author(s):  
Sara Mazzilli ◽  
Reyes Gamo-Villegas ◽  
Ana Pampin-Franco ◽  
Jose Luis Lopez Estebaran ◽  
Fernando Pinedo ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Cell Carcinoma ◽  
Histopathological Examination ◽  
Case Series ◽  
The Body ◽  
Reflectance Confocal Microscopy ◽  
Bowen’S Disease ◽  
Seborrheic Keratosis ◽  
Bowen's Disease ◽  
Precise Diagnosis

Pigmented Bowen’s disease is a rare variant of in situ squamous skin cell carcinoma. It mainly affects patients between 60 and 70 years of age. Its clinical features include well-demarcated, pigmented plaque arising in photo-exposed areas of the body. The best-characterized feature of the disease by histological examination is the presence of atypical keratinocytes, hyperpigmentation of the epidermis with trans-epidermal elimination of melanin and dermal melanophages. Precise diagnosis is often difficult, both clinically and dermoscopically, as Bowen’s disease is often mistaken with keratinocyte tumors such as solar lentigines, seborrheic keratosis, Bowenoid papulosis, pigmented basal cell carcinoma, pigmented actinic keratosis; or even melanocytic lesions such as melanocytic nevus, pigmented epithelioid melanocytoma, and melanoma. Precise diagnosis often requires biopsy and histopathological examination of the tissue. Reflectance confocal microscopy is a noninvasive technique to diagnose pigmented skin lesions. To date, not much data are available regarding its use in the diagnosis of pigmented Bowen’s disease. Herein, we report a well-represented case series of pigmented Bowen’s disease imaged using dermoscopy and reflectance confocal microscopy.

scholarly journals Langerhans Cells as Morphologic Mimickers of Atypical Melanocytes on Reflectance Confocal Microscopy: A Case Report and Review of the Literature

2021 ◽  
pp. 2021078
Author(s):  
Nadiya Chuchvara ◽  
Lauren Berger ◽  
Catherine Reilly ◽  
Amin Maghari ◽  
Babar Rao
Keyword(s):  
Dendritic Cells ◽  
Confocal Microscopy ◽  
Langerhans Cells ◽  
Melanocytic Nevus ◽  
Reflectance Confocal Microscopy ◽  
Lentigo Maligna ◽  
Lentigo Maligna Melanoma ◽  
Atypical Cells ◽  
Neoplastic Process ◽  
Solar Lentigo

Pagetoid spread of melanocytes in the epidermis is a common indicator of melanocytic atypia, both histopathologically and with reflectance confocal microscopy (RCM). Specifically on RCM, large, bright, atypical dendritic and/or roundish cells are characteristic of melanoma. However, intraepidermal Langerhans cells (ILC) create the potential for diagnostic ambiguity on RCM. We describe one case of a pigmented facial lesion that was initially diagnosed as lentigo maligna (LM) due to numerous atypical perifollicular dendritic cells on RCM. Additionally, we present the findings of a literature review for similar reported cases conducted by searching the following terms on PubMed: reflectance confocal microscopy, RCM, lentigo maligna, melanoma, Langerhans cells, dendritic cells, and atypical cells. In our case, the lesion was determined to be a solar lentigo on histopathology. Immunohistochemistry (IHC) with CD1a identified the atypical-appearing cells as ILC, as it did in 54 reported cases of benign lesions (benign melanocytic nevus, Sutton/halo nevus, labial melanotic macule, and solar lentigo) misdiagnosed as malignant on RCM (melanoma, lip melanoma, lentigo maligna, and LM melanoma). According to our case and the literature, both ILC and atypical melanocytes can present with atypical-appearing dendritic and/or roundish cells under RCM. Currently, there is no method to distinguish the two without IHC. Therefore, the presence of pagetoid cells should continue to alert the confocalist of a potential neoplastic process, prompting biopsy, histopathologic diagnosis, and IHC differentiation.    

Treatment of multifocal Bowen's disease with a specially designed radioactive skin patch

1998 ◽  
Vol 139 (5) ◽  
pp. 938-939 ◽  
Author(s):  
Chung ◽  
Bang ◽  
Lee ◽  
Sung ◽  
Park ◽  
...  
Keyword(s):  
Bowen’S Disease ◽  
Bowen's Disease ◽  
Skin Patch

Macular Bowen's disease

1978 ◽  
Vol 114 (2) ◽  
pp. 282-282
Author(s):  
D. A. Weigand
Keyword(s):  
Bowen’S Disease ◽  
Bowen's Disease
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