scholarly journals Impact of diabetes-related gene polymorphisms on the clinical characteristics of type 2 diabetes Chinese Han population

Oncotarget ◽  
2016 ◽  
Vol 7 (51) ◽  
pp. 85464-85471 ◽  
Author(s):  
Jing Li ◽  
Jiachen Wei ◽  
Pengcheng Xu ◽  
Mengdan Yan ◽  
Jingjie Li ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gene Polymorphisms ◽  
Clinical Characteristics ◽  
Chinese Han Population ◽  
Related Gene ◽  
Chinese Han ◽  
Han Population

Relationship Between SLC22A1 and SLC22A4 Gene Polymorphisms and Risk of Type 2 Diabetes in Chinese Han Population

2018 ◽  
Vol 64 (09/2018) ◽  
Author(s):  
Guanghui Long ◽  
Guangtao Zhang ◽  
Fangting Zhang ◽  
Dongshuo Ye ◽  
Dengke Yang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Relationship between SLC22A1 and SLC22A4 gene polymorphisms and risks of type 2 diabetes in Chinese Han population

2018 ◽  
Vol 29 (5) ◽  
Author(s):  
Guanghui Long ◽  
Guangtao Zhang ◽  
Fangting Zhang ◽  
Dongshuo Ye ◽  
Dengke Yang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Impact of variants of the EXT2 gene on Type 2 diabetes and its related traits in the Chinese han population

2014 ◽  
Vol 40 (2) ◽  
pp. 79-82 ◽  
Author(s):  
Qian Ren ◽  
Jianzhong Xiao ◽  
Xueyao Han ◽  
Wenying Yang ◽  
Linong Ji
Keyword(s):  
Type 2 Diabetes ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Association between PNPLA2 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in a Chinese Han Population with Type 2 Diabetes

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Hailing Zhao ◽  
Haojun Zhang ◽  
Yan Wang ◽  
Tingting Zhao ◽  
Meihua Yan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Odds Ratio ◽  
Diabetic Kidney Disease ◽  
Adjusted Odds Ratio ◽  
Additive Model ◽  
Chinese Han Population ◽  
Dominant Model ◽  
Chinese Han ◽  
Han Population

Diabetic kidney disease (DKD) is one of the most common complications of diabetes and the leading cause of end-stage renal disease. Here, we investigated the association of PNPLA2 gene variations with DKD susceptibility in a Chinese Han population. A total of 818 participants with type 2 diabetes were recruited in the case-control study, including 379 patients diagnosed with DKD. We observed that 2 tagSNPs, PNPLA2 rs28633403 (A>G) and rs1138714 (A>G), were associated with DKD (rs28633403: genotype, P=0.017; allele, P=0.015; rs1138714: genotype, P=0.029; allele, P=0.018). PNPLA2 rs1138693 (T>C), a missense SNP, showed no association with DKD (genotype, P=0.966; allele, P=0.845). Genetic model analysis revealed that minor allele G of PNPLA2 rs28633403 was a protective factor of DKD in a dominant model adjusted by confounders (AG+GG vs. AA: adjusted odds ratio (aOR), 0.619; 95% CI 0.447-0.857; P=0.004) and in an additive model (AG vs. AA: aOR, 0.633; 95% CI 0.447-0.895; P=0.010; GG vs. AA: aOR, 0.588; 95% CI 0.385-0.897; P=0.014). Minor allele G of PNPLA2 rs1138714 was associated with a higher risk of DKD in a dominant model adjusted by confounders (AG+GG vs. AA: adjusted odds ratio (aOR), 1.531; 95% CI 1.134-2.067; P=0.005) and in an additive model (AG vs. AA: aOR, 1.529; 95% CI 1.118-2.091; P=0.008). The combined effect of PNPLA2 rs28633403 AA+rs1138714 AG or GG genotype showed an association with DKD, adjusted by confounders (aOR, 2.194; 95% CI 1.378-3.492; P=0.001), which was considered statistically significant with a markedly increased risk of DKD after a Holm-Bonferroni correction for multiple tests (P<0.00125). Our results suggest that PNPLA2 rs28633403 and rs1138714 are significantly associated with the risk of DKD in a Chinese Han population with type 2 diabetes.

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