Risk Factors for Antenatal Depression and Associations with Infant Birth Outcomes: Results From a South African Birth Cohort Study

2015 ◽  
Vol 29 (6) ◽  
pp. 505-514 ◽  
Author(s):  
Kirsty Brittain ◽  
Landon Myer ◽  
Nastassja Koen ◽  
Sheri Koopowitz ◽  
Kirsten A. Donald ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
South African ◽  
Birth Cohort ◽  
Birth Outcomes ◽  
Antenatal Depression ◽  
Birth Cohort Study ◽  
Infant Birth Outcomes ◽  
Infant Birth

scholarly journals Maternal health and birth outcomes in a South African birth cohort study

PLoS ONE ◽  
2019 ◽  
Vol 14 (11) ◽  
pp. e0222399 ◽  
Author(s):  
Heather J. Zar ◽  
Jennifer A. Pellowski ◽  
Sophie Cohen ◽  
Whitney Barnett ◽  
Aneesa Vanker ◽  
...  
Keyword(s):  
Cohort Study ◽  
Maternal Health ◽  
South African ◽  
Birth Cohort ◽  
Birth Outcomes ◽  
Birth Cohort Study

scholarly journals Birth Outcomes in a Prospective Pregnancy-Birth Cohort Study of Environmental Risk Factors in Kuwait: The TRACER Study

2016 ◽  
Vol 30 (4) ◽  
pp. 408-417 ◽  
Author(s):  
Mohammad AlSeaidan ◽  
Rihab Al Wotayan ◽  
Costas A. Christophi ◽  
Massouma Al-Makhseed ◽  
Yara Abu Awad ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Birth Cohort ◽  
Birth Outcomes ◽  
Environmental Risk ◽  
Environmental Risk Factors ◽  
Birth Cohort Study ◽  
Tracer Study

scholarly journals Maternal psychosocial risk factors and offspring gestational epigenetic age acceleration in a South African birth cohort study

2018 ◽  
Author(s):  
Nastassja Koen ◽  
Meaghan Jones ◽  
Raymond T. Nhapi ◽  
Kirsten A. Donald ◽  
Whitney Barnett ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
South African ◽  
Birth Cohort ◽  
Stepwise Regression ◽  
Psychosocial Risk Factors ◽  
Psychosocial Risk ◽  
Birth Cohort Study ◽  
Maternal Trauma ◽  
Epigenetic Age

Epigenetic age (EA) acceleration is associated with higher risk of chronic disease and mortality in adults. However, little is known about whether and how in utero exposures might shape gestational EA acceleration at birth. We aimed to explore associations between maternal psychosocial risk factors and offspring gestational EA acceleration at birth in a South African birth cohort study - the Drakenstein Child Health Study. Maternal psychosocial risk factors included trauma/stressor exposure; posttraumatic stress disorder (PTSD); depression, psychological distress; and alcohol/tobacco use. Offspring gestational EA acceleration at birth was calculated using an epigenetic clock previously devised for neonates. Bivariate linear regression was used to explore unadjusted associations between maternal risk factors and offspring gestational EA acceleration at birth. A stepwise regression method was then used to determine the best multivariable model for adjusted associations. Data from 272 maternal-offspring dyads were included in the current analysis. In the stepwise regression model, maternal trauma exposure (β = 7.92; p<0.01) or PTSD (β = 7.46; p<0.01) were significantly associated with offspring gestational EA acceleration at birth, controlling for ethnicity, offspring sex, head circumference at birth, maternal HIV status, and prenatal tobacco or alcohol use. In site-stratified models, these associations retained statistical significance and direction of effect. Maternal trauma exposure or PTSD may thus be associated with offspring gestational EA acceleration at birth. Given the novelty of this preliminary finding, and its potential translational relevance, further studies to delineate underlying biological pathways and to explore clinical implications of EA acceleration are warranted.

scholarly journals Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study

2013 ◽  
Vol 12 (1) ◽  
Author(s):  
Dennis Liang Fei ◽  
Devin C Koestler ◽  
Zhigang Li ◽  
Camilla Giambelli ◽  
Avencia Sanchez-Mejias ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cohort Study ◽  
Birth Weight ◽  
Birth Cohort ◽  
Arsenic Exposure ◽  
In Utero ◽  
Birth Cohort Study ◽  
Infant Birth

scholarly journals The University of Zimbabwe College of Health Sciences (UZ-CHS) BIRTH COHORT study: rationale, design and methods

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Kerina Duri ◽  
◽  
Felicity Z. Gumbo ◽  
Privilege T. Munjoma ◽  
Precious Chandiwana ◽  
...  
Keyword(s):  
Cohort Study ◽  
Amniotic Fluid ◽  
Birth Cohort ◽  
Birth Outcomes ◽  
Early Life ◽  
Health Sciences ◽  
Birth Cohort Study ◽  
Adverse Birth Outcomes ◽  
The University ◽  
University Of Zimbabwe

Abstract Background Commencing lifelong antiretroviral therapy (ART) immediately following HIV diagnosis (Option B+), has greatly improved maternal-infant health. Thus, large and increasing numbers of HIV-infected women are on ART during pregnancy, a situation concurrently increasing numbers of HIV-exposed-uninfected (HEU) infants. Compared to their HIV-unexposed-uninfected (HUU) counterparts, HEU infants show higher rates of adverse birth outcomes, mortality, infectious/non-communicable diseases including impaired growth and neurocognitive development. There is an urgent need to understand the impact of HIV and early life ART exposures, immune-metabolic dysregulation, comorbidities and environmental confounders on adverse paediatric outcomes. Methods Six hundred (600) HIV-infected and 600 HIV-uninfected pregnant women ≥20 weeks of gestation will be enrolled from four primary health centres in high density residential areas of Harare. Participants will be followed up as mother-infant-pairs at delivery, week(s) 1, 6, 10, 14, 24, 36, 48, 72 and 96 after birth. Clinical, socio-economic, nutritional and environmental data will be assessed for adverse birth outcomes, impaired growth, immune/neurodevelopment, vertical transmission of HIV, hepatitis-B/C viruses, cytomegalovirus and syphilis. Maternal urine, stool, plasma, cord blood, amniotic fluid, placenta and milk including infant plasma, dried blood spot and stool will be collected at enrolment and follow-up visits. The composite primary endpoint is stillbirth and infant mortality within the first two years of life in HEU versus HUU infants. Maternal mortality in HIV-infected versus -uninfected women is another primary outcome. Secondary endpoints include a range of maternal and infant outcomes. Sub-studies will address maternal stress and malnutrition, maternal-infant latent tuberculosis, Helicobacter pylori infections, immune-metabolomic dysregulation including gut, breast milk and amniotic fluid dysbiosis. Discussion The University of Zimbabwe-College of Health-Sciences-Birth-Cohort study will provide a comprehensive assessment of risk factors and biomarkers for HEU infants’ adverse outcomes. This will ultimately help developing strategies to mitigate effects of maternal HIV, early-life ART exposures and comorbidities on infants’ mortality and morbidity. Trial registration ClinicalTrial.gov Identifier: NCT04087239. Registered 12 September 2019.

Prevalence of and risk factors for atopic dermatitis: A birth cohort study of infants in southeast Turkey

2016 ◽  
Vol 44 (3) ◽  
pp. 214-220 ◽  
Author(s):  
D. Doğruel ◽  
G. Bingöl ◽  
D.U. Altıntaş ◽  
M. Yılmaz ◽  
S.G. Kendirli
Keyword(s):  
Risk Factors ◽  
Atopic Dermatitis ◽  
Cohort Study ◽  
Birth Cohort ◽  
Birth Cohort Study
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