Central mucoepidermoid carcinoma arising from glandular odontogenic cyst confirmed by analysis of MAML2 rearrangement: A case report

2017 ◽  
Vol 68 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Atsuhiro Nagasaki ◽  
Ikuko Ogawa ◽  
Yukiko Sato ◽  
Kengo Takeuchi ◽  
Masae Kitagawa ◽  
...  
Keyword(s):  
Case Report ◽  
Mucoepidermoid Carcinoma ◽  
Odontogenic Cyst ◽  
Glandular Odontogenic Cyst ◽  
Central Mucoepidermoid Carcinoma

scholarly journals Glandular Odontogenic Cyst: Review of Literature and Report of a New Case with Cytokeratin-19 Expression

2014 ◽  
Vol 8 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Marco Mascitti ◽  
Andrea Santarelli ◽  
Antonio Sabatucci ◽  
Maurizio Procaccini ◽  
Lorenzo Lo Muzio ◽  
...  
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Squamous Epithelium ◽  
Odontogenic Cyst ◽  
Cytokeratin 19 ◽  
Review Of Literature ◽  
Distinct Entity ◽  
Radiographic Findings ◽  
Glandular Odontogenic Cyst ◽  
Stratified Squamous Epithelium ◽  
Central Mucoepidermoid Carcinoma

The glandular odontogenic cyst (GOC) was a rare jawbone cyst described in 1988 as a distinct entity. This lesion can involve either jaw, and the anterior region of the mandible was the most commonly affected area. Clinical and radiographic findings were not specific, and the diagnosis of GOC can be extremely difficult due to the rarity of this lesion. The cyst presented a wall constituted by fibrous connective tissue and was lined by a non-keratinized stratified squamous epithelium of variable thickness. Large areas of the lining epithelium presented cylinder cells, sometimes ciliated. A variable amount of mucina was occasionally noted. Due to the strong similarities, this cyst can be easily misdiag-nosed as a central mucoepidermoid carcinoma (CMEC). Immunohistochemistry may be an aid in diagnosis; in fact has been demonstrated that there were differences in the expression of cytokeratins (CK) in GOC and CMEC. In this study, we reported a new case of GOC in a 38 year female patient. In addition, we carried out a review of 110 previous cases reported in literature.

scholarly journals High-grade central mucoepidermoid carcinoma arising in an odontogenic cyst: a case report and review of the literature

2018 ◽  
Vol 71 (4) ◽  
pp. 365-372
Author(s):  
Paweł Świerzy ◽  
Mariusz Szuta ◽  
Romana Tomaszewska ◽  
Jadwiga Stypułkowska ◽  
Hiba Alobaide ◽  
...  
Keyword(s):  
Case Report ◽  
Mucoepidermoid Carcinoma ◽  
Odontogenic Cyst ◽  
High Grade ◽  
Review Of The Literature ◽  
Central Mucoepidermoid Carcinoma

scholarly journals Central mucoepidermoid carcinoma of the maxilla developing from a calcifying odontogenic cyst: A rare case report

2021 ◽  
Vol 9 (10) ◽  
Author(s):  
Megumi Isshiki‐Murakami ◽  
Hidetake Tachinami ◽  
Kei Tomihara ◽  
Akira Noguchi ◽  
Katsuhisa Sekido ◽  
...  
Keyword(s):  
Case Report ◽  
Mucoepidermoid Carcinoma ◽  
Rare Case ◽  
Odontogenic Cyst ◽  
Calcifying Odontogenic Cyst ◽  
Rare Case Report ◽  
Central Mucoepidermoid Carcinoma

Cytokeratin expression in central mucoepidermoid carcinoma and glandular odontogenic cyst

Oral Oncology ◽  
2004 ◽  
Vol 40 (5) ◽  
pp. 545-551 ◽  
Author(s):  
Fábio Ramôa Pires ◽  
Sow-Yeh Chen ◽  
Danyel Elias da Cruz Perez ◽  
Oslei Paes de Almeida ◽  
Luiz Paulo Kowalski
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Odontogenic Cyst ◽  
Glandular Odontogenic Cyst ◽  
Cytokeratin Expression ◽  
Central Mucoepidermoid Carcinoma

scholarly journals Central Mucoepidermoid Carcinoma Arising Directly From a Glandular Odontogenic Cyst of the Mandible: A Case Report

2021 ◽  
Author(s):  
Satoshi Maruyama ◽  
Taisuke Mori ◽  
Manabu Yamazaki ◽  
Tatsuya Abé ◽  
Eijitsu Ryo ◽  
...  
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Rare Case ◽  
Salivary Gland Tumor ◽  
Third Molar ◽  
Odontogenic Cyst ◽  
Glandular Odontogenic Cyst ◽  
Old Japanese ◽  
Central Mucoepidermoid Carcinoma ◽  
Intermediate Cells ◽  
The Right

Abstract BackgroundCentral mucoepidermoid carcinoma (MEC) is a rare salivary gland tumor that affects the jaw bone. Glandular odontogenic cyst (GOC) is also a rare odontogenic developmental cyst with glandular differentiation. GOC shares some histological features with central MEC, and a pre-existing GOC can develop into central MEC. Here, we present a rare case of central MEC developed directly from a pre-existing GOC of the mandible. Case presentationA 67-year-old Japanese man presented with a cystic lesion in the right third molar region. Histologically, the biopsy specimen demonstrated both typical of a GOC component lined with non-keratinized squamous epithelium and a recognizable component of central MEC consisting of polycystic nests with mucous cells, intermediate cells, and epidermoid cells in the cyst wall. The immunohistochemistry for cytokeratin (CK) profile results demonstrated that while both central MEC and GOC expressed CKs 7, 14, 18, and 19, interestingly CK13 was only expressed in GOC. Fluorescence in-situ hybridization (FISH) revealed the rearrangement of the Mastermind like (MAML)-2 gene in both MEC and GOC components. ConclusionsOur case suggests that central MEC and GOC may be in the same spectrum of diseases caused by rearrangement of the MAML-2 gene. At the same time, the expression profile of CK13 was completely different in both central MEC and GOC. This also suggests that central MEC is a distinct tumor from GOC. Thus, we demonstrated the rare case that central MEC may have originated directly from the GOC.

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