Regeneration using endogenous neural stem cells following neonatal brain injury

2020 ◽  
Author(s):  
Hideo Jinno
Keyword(s):  
Stem Cells ◽  
Brain Injury ◽  
Neural Stem Cells ◽  
Neonatal Brain ◽  
Neonatal Brain Injury ◽  
Endogenous Neural Stem Cells

Activation of endogenous neural stem cells after traumatic brain injury

The Lancet ◽  
2014 ◽  
Vol 383 ◽  
pp. S18 ◽  
Author(s):  
Aminul Ahmed ◽  
Anan Shtaya ◽  
Malik Zaben ◽  
William Gray
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Brain Injury ◽  
Neural Stem Cells ◽  
Endogenous Neural Stem Cells

Stem Cell Studies in Traumatic Brain Injury

Neurotrauma ◽  
2018 ◽  
pp. 373-386
Author(s):  
Dong Sun
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Stem Cell ◽  
Brain Injury ◽  
Neural Stem Cells ◽  
Cell Transplantation ◽  
Survival Rates ◽  
Structural Repair ◽  
Potential Strategy ◽  
Endogenous Neural Stem Cells

Traumatic brain injury (TBI) is a global public health concern, with limited treatment options available. Despite improving survival rates after TBI, there is no effective treatment to improve the neural structural repair and functional recovery of patients. Neural regeneration through neural stem cells, either by stimulating endogenous neural stem cells or by stem cell transplantation, has gained increasing attention as a potential strategy to repair and regenerate the injured brain. This chapter summarizes strategies that have been explored to enhance endogenous neural stem cells-mediated regeneration and recent developments in cell transplantation studies for post-TBI brain repair with varying types of cell sources.

148. Treatment of Neonatal Brain Injury with Mesenchymal Stem Cells

2012 ◽  
Vol 26 ◽  
pp. S41
Author(s):  
C.T. van Velthoven ◽  
V. Donega ◽  
C.H. Nijboer ◽  
A. Kavelaars ◽  
C.J. Heijnen
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Brain Injury ◽  
Neonatal Brain ◽  
Neonatal Brain Injury

scholarly journals Acupuncture Induces the Proliferation and Differentiation of Endogenous Neural Stem Cells in Rats with Traumatic Brain Injury

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Shuting Jiang ◽  
Weihao Chen ◽  
Yimin Zhang ◽  
Yujuan Zhang ◽  
Ailian Chen ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Brain Injury ◽  
Neural Stem Cells ◽  
Calcium Binding ◽  
Acupuncture Group ◽  
Sprague Dawley ◽  
Neural Repair ◽  
Proliferation And Differentiation ◽  
Endogenous Neural Stem Cells

Purpose. To investigate whether acupuncture induced the proliferation and differentiation of endogenous neural stem cells (NSCs) in a rat model of traumatic brain injury (TBI).Methods. 104 Sprague-Dawley rats were randomly divided into normal, model, and acupuncture groups. Each group was subdivided into three-day (3 d), seven-day (7 d), and fourteen-day (14 d) groups. The rat TBI model was established using Feeney’s freefall epidural impact method. The rats in the acupuncture group were treated at acupoints (Baihui, Shuigou, Fengfu, Yamen, and bilateral Hegu). The normal and model groups did not receive acupuncture. The establishment of the rat TBI model and the therapeutic effect of acupuncture were assessed using neurobehavioral scoring and hematoxylin-eosin staining. The proliferation and differentiation of NSCs in TBI rats were analyzed using immunofluorescence microscopy.Results. The levels of nestin-expressing cells and bromodeoxyuridine/glial fibrillary acidic protein- (BrdU/GFAP-) and BrdU/S100 calcium-binding protein B-positive and BrdU/microtubule-associated protein 2- and BrdU/galactocerebrosidase-positive cells were more significantly increased at various time points in the acupuncture group than in the model group (P<0.01), except for a decreased level of BrdU/GFAP-positive cells at 7 d and 14 d.Conclusion. Acupuncture induced the proliferation and differentiation of NSCs, thereby promoting neural repair in the TBI rats.

Sign in / Sign up

Export Citation Format

Share Document