Manipulation of Endogenous Neural Stem Cells Following Ischemic Brain Injury

2006 ◽  
Vol 35 (1-2) ◽  
pp. 58-62 ◽  
Author(s):  
R.R. Leker
Keyword(s):  
Stem Cells ◽  
Brain Injury ◽  
Neural Stem Cells ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Endogenous Neural Stem Cells

scholarly journals Human Neural Stem Cells: Translational Research for Neonatal Hypoxic-Ischemic Brain Injury

2019 ◽  
Vol 26 (1) ◽  
pp. 1-16
Author(s):  
Jeong Eun Shin ◽  
Jungho Han ◽  
Joo Hee Lim ◽  
Ho Seon Eun ◽  
Kook In Park
Keyword(s):  
Stem Cells ◽  
Brain Injury ◽  
Neural Stem Cells ◽  
Translational Research ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Human Neural Stem Cells ◽  
Hypoxic Ischemic Brain Injury

scholarly journals Therapeutic Potential of Neurotrophic Factors and Neural Stem Cells Against Ischemic Brain Injury

2000 ◽  
Vol 20 (10) ◽  
pp. 1393-1408 ◽  
Author(s):  
Koji Abe
Keyword(s):  
Stem Cells ◽  
Brain Injury ◽  
Neural Stem Cells ◽  
Neurotrophic Factors ◽  
Therapeutic Potential ◽  
Stem Cell Differentiation ◽  
Adult Brain ◽  
Ischemic Brain Injury ◽  
Ischemic Brain

Development of neuronal and glial cells and their maintenance are under control of neurotrophic factors (NTFs). An exogenous administration of NTFs protects extremely sensitive brain tissue from ischemic damage. On the other hand, it is now known that neural stem cells are present in normal adult brain, and have a potential to compensate and recover neural functions that were lost due to ischemic stroke. These stem cells are also under control of NTFs to differentiate into a certain species of neural cells. Thus, the purpose of this review is to summarize the present understanding of the role of NTFs in normal and ischemic brain and the therapeutic potential of NTF protein itself or gene therapy, and then to summarize the role of NTFs in stem cell differentiation and a possible therapeutic potential with the neural stem cells against ischemic brain injury.

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