A window of hope: Cell therapy using neural stem cells for neonatal brain injury

2021 ◽  
Vol 63 (1) ◽  
pp. 3-4
Author(s):  
Atsushi Uchiyama
Keyword(s):  
Stem Cells ◽  
Brain Injury ◽  
Cell Therapy ◽  
Neural Stem Cells ◽  
Neonatal Brain ◽  
Neonatal Brain Injury

scholarly journals Baby STEPS: A Giant Leap for Cell Therapy in Neonatal Brain Injury

2011 ◽  
Vol 70 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Cesar V Borlongan ◽  
Michael D Weiss
Keyword(s):  
Brain Injury ◽  
Cell Therapy ◽  
Neonatal Brain ◽  
Neonatal Brain Injury ◽  
Giant Leap

148. Treatment of Neonatal Brain Injury with Mesenchymal Stem Cells

2012 ◽  
Vol 26 ◽  
pp. S41
Author(s):  
C.T. van Velthoven ◽  
V. Donega ◽  
C.H. Nijboer ◽  
A. Kavelaars ◽  
C.J. Heijnen
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Brain Injury ◽  
Neonatal Brain ◽  
Neonatal Brain Injury

scholarly journals Efficient and Fast Differentiation of Human Neural Stem Cells from Human Embryonic Stem Cells for Cell Therapy

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Xinxin Han ◽  
Liming Yu ◽  
Jie Ren ◽  
Min Wang ◽  
Zhongliang Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Brain Injury ◽  
Cell Therapy ◽  
Neural Stem Cells ◽  
Embryonic Stem ◽  
Great Promise ◽  
Marker Genes ◽  
Differentiation Potential ◽  
Human Neural Stem Cells ◽  
Hes Cells

Stem cell-based therapies have been used for repairing damaged brain tissue and helping functional recovery after brain injury. Aberrance neurogenesis is related with brain injury, and multipotential neural stem cells from human embryonic stem (hES) cells provide a great promise for cell replacement therapies. Optimized protocols for neural differentiation are necessary to produce functional human neural stem cells (hNSCs) for cell therapy. However, the qualified procedure is scarce and detailed features of hNSCs originated from hES cells are still unclear. In this study, we developed a method to obtain hNSCs from hES cells, by which we could harvest abundant hNSCs in a relatively short time. Then, we examined the expression of pluripotent and multipotent marker genes through immunostaining and confirmed differentiation potential of the differentiated hNSCs. Furthermore, we analyzed the mitotic activity of these hNSCs. In this report, we provided comprehensive features of hNSCs and delivered the knowledge about how to obtain more high-quality hNSCs from hES cells which may help to accelerate the NSC-based therapies in brain injury treatment.

scholarly journals Stem cell therapy for neonatal brain injury: Perspectives and Challenges

2011 ◽  
Vol 70 (5) ◽  
pp. 698-712 ◽  
Author(s):  
Luigi Titomanlio ◽  
Annemieke Kavelaars ◽  
Jeremie Dalous ◽  
Shyamala Mani ◽  
Vincent El Ghouzzi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Brain Injury ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Neonatal Brain ◽  
Neonatal Brain Injury

Stem Cell Therapy for Neonatal Brain Injury

2014 ◽  
Vol 41 (1) ◽  
pp. 133-148 ◽  
Author(s):  
Bobbi Fleiss ◽  
Pascale V. Guillot ◽  
Luigi Titomanlio ◽  
Olivier Baud ◽  
Henrik Hagberg ◽  
...  
Keyword(s):  
Stem Cell ◽  
Brain Injury ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Neonatal Brain ◽  
Neonatal Brain Injury

scholarly journals BMP4/LIF or RA/Forskolin Suppresses the Proliferation of Neural Stem Cells Derived from Adult Monkey Brain

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Xinxin Han ◽  
Liming Yu ◽  
Qingqing Chen ◽  
Min Wang ◽  
Jie Ren ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Brain Injury ◽  
Cell Therapy ◽  
Neural Stem Cells ◽  
Cell Morphology ◽  
Nonhuman Primates ◽  
Neural Progenitor Cells ◽  
Combined Treatment ◽  
Monkey Brain

Monkeys are much closer to human and are the most common nonhuman primates which are used in biomedical studies. Neural progenitor cells can originate from the hippocampus of adult monkeys. Despite a few reports, the detailed properties of monkey neural stem cells (NSCs) and their responses to cytokine are still unclear. Here, we derive NSCs from an adult monkey brain and demonstrate that BMP4 inhibits cell proliferation and affects cell morphology of monkey NSCs. Combined treatment of BMP4 and LIF or RA and Forskolin represses the proliferation of monkey NSCs. We also show that BMP4 may promote monkey NSC quiescence. Our study therefore provides implications for NSC-based cell therapy of brain injury in the future.

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