Pediatric Old World cutaneous leishmaniasis treated with oral fluconazole: A case series

2018 ◽  
Vol 35 (3) ◽  
pp. 384-387 ◽  
Author(s):  
Andrea Michelerio ◽  
Stefania Barruscotti ◽  
Grazia Bossi ◽  
Valeria Brazzelli
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Case Series ◽  
Oral Fluconazole ◽  
Old World

Efficacy of erbium glass laser in the treatment of Old World cutaneous leishmaniasis: A case series

2018 ◽  
Vol 60 (1) ◽  
pp. e29-e32 ◽  
Author(s):  
Vahid Mashayekhi Goyonlo ◽  
Mahboubeh Karrabi ◽  
Bita Kiafar
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Case Series ◽  
Glass Laser ◽  
Old World ◽  
Erbium Glass

scholarly journals Efficacy and safety of treatment for Old World cutaneous leishmaniasis in pediatric patients: a case series

2021 ◽  
Author(s):  
Tomàs Boal Cunha ◽  
Thomas Bieber ◽  
Ingrid Reiter‐Owona ◽  
Jörg Wenzel ◽  
Julia Altengarten ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Pediatric Patients ◽  
Case Series ◽  
Efficacy And Safety ◽  
Old World

scholarly journals Miltefosine for Mucosal and Complicated Cutaneous Old World Leishmaniasis: A Case Series and Review of the Literature

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
Vincent Mosimann ◽  
Claudia Blazek ◽  
Heini Grob ◽  
Matthew Chaney ◽  
Andreas Neumayr ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Cutaneous Leishmaniasis ◽  
Clinical Studies ◽  
Systemic Treatment ◽  
Treatment Options ◽  
Case Series ◽  
Review Of The Literature ◽  
Effective Treatment Option ◽  
Old World ◽  
Mucosal Leishmaniasis

Abstract Complicated Old World cutaneous leishmaniasis (OWCL) and Old World mucosal leishmaniasis (OWML) constitute an indication for systemic treatment. To date, there no controlled clinical studies that compare treatment options for these diseases. We compiled a case series of 24 cases successfully treated with miltefosine. We conclude that oral miltefosine is an effective treatment option for both OWCL and OWML.

scholarly journals 766. Everything Old is New Again-A Case Series of New World Leishmaniasis in African Children in Portland, Maine

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S428-S428
Author(s):  
Jennifer Jubulis ◽  
Amanda Goddard ◽  
Elizabeth Seiverling ◽  
Marc Kimball ◽  
Carol A McCarthy
Keyword(s):  
Latin America ◽  
Cutaneous Leishmaniasis ◽  
New World ◽  
Pediatric Patients ◽  
Data Extraction ◽  
Clinical Manifestations ◽  
Case Series ◽  
Surgical Excision ◽  
Skin Lesions ◽  
Travel History

Abstract Background Leishmaniasis has many clinical manifestations and treatment regimens, dependent on species and host. Old world leishmaniasis is found primarily in Africa and Asia, and is associated with visceral disease, while new world disease, seen primarily in Latin America, is more commonly mucocutaneous. We present a case series of pediatric African patients with New World cutaneous leishmaniasis (NWCL). Methods Data extraction was performed via chart review, analyzing travel history, clinical presentation, diagnosis, and management in children with cutaneous leishmaniasis presenting to the pediatric infectious diseases clinic in Portland, ME. Biopsy specimens were sent to the federal CDC for identification by PCR and culture. Results Five cases of NWCL were diagnosed in pediatric patients in Maine from November 2018 through February 2020. Median age of patients was 10 years (range 1.5-15 years). Four cases (80%) occurred in children from Angola or Democratic Republic of Congo, arriving in Maine via Central/South America, with one case in a child from Rwanda who arrived in Maine via Texas. Three patients had multiple skin lesions and two had isolated facial lesions. Leishmaniasis was not initially suspected resulting in median time to diagnosis of 5 months (range 1-7 months). Four patients were initially treated with antibacterials for cellulitis and one was treated with griseofulvin. After no improvement, patients underwent biopsy with 2 patients diagnosed with L panamensis, 1 with L braziliensis, 1 with mixed infection (L panamensis and L mexicana), and 1 with Leishmania species only. One patient was managed with surgical excision, 3 with ketoconazole, and 1 was observed off therapy. Four patients were referred to otolaryngology. All continue to be followed in infectious disease clinic. Conclusion We present five cases of new world cutaneous leishmaniasis in African pediatric patients arriving to Maine through Latin America or Texas. Patients were diagnosed with cellulitis, tinea corporis or atopic dermatitis initially, underscoring importance of high index of suspicion in migrant patients. Detailed travel history and epidemiologic knowledge is essential to diagnosis, as patients may present with illness not congruent with country of origin. Optimal therapy remains unclear. Disclosures All Authors: No reported disclosures

scholarly journals An investigation of the effects of environmental and ecologic factors on cutaneous leishmaniasis in the old world: a systematic review study

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Abolfazl Mohammadbeigi ◽  
Salman Khazaei ◽  
Hamidreza Heidari ◽  
Azadeh Asgarian ◽  
Shahram Arsangjang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Environmental Factors ◽  
Land Cover ◽  
Cutaneous Leishmaniasis ◽  
Weather Condition ◽  
Weather Conditions ◽  
Eligibility Criteria ◽  
Screening Process ◽  
Old World ◽  
Review Study

AbstractObjectivesLeishmaniasis is a neglected and widespread parasitic disease that can lead to serious health problems. The current review study aimed to synthesize the relationship between ecologic and environmental factors (e.g., weather conditions, climatology, temperature and topology) and the incidence of cutaneous leishmaniasis (CL) in the Old World.ContentA systematic review was conducted based on English, and Persian articles published from 2015 to 2020 in PubMed/Medline, Science Direct, Web of Science and Google Scholar. Keywords used to search articles were leishmaniasis, environmental factors, weather condition, soil, temperature, land cover, ecologic* and topogr*. All articles were selected and assessed for eligibility according to the titles or abstracts. The quality screening process of articles was carried out by two independent authors. The selected articles were checked according to the inclusion and exclusion criteria.Summary and outlookA total of 827 relevant records in 2015–2020 were searched and after evaluating the articles, 23 articles met the eligibility criteria; finally, 14 full-text articles were included in the systematic review. Two different categories of ecologic/environmental factors (weather conditions, temperature, rainfall/precipitation and humidity) and land characteristics (land cover, slope, elevation and altitude, earthquake and cattle sheds) were the most important factors associated with CL incidence.ConclusionsTemperature and rainfall play an important role in the seasonal cycle of CL as many CL cases occurred in arid and semiarid areas in the Old World. Moreover, given the findings of this study regarding the effect of weather conditions on CL, it can be concluded that designing an early warning system is necessary to predict the incidence of CL based on different weather conditions.

Peripheral Nerve Involvement in Cutaneous Leishmaniasis (Old World)

1987 ◽  
Vol 26 (8) ◽  
pp. 527-531 ◽  
Author(s):  
Raj Kubba ◽  
A. M. El-Hassan ◽  
Yussuf Al-Gindan ◽  
A. H. S. Omer ◽  
Mehmoud Bushra ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Cutaneous Leishmaniasis ◽  
Old World ◽  
Nerve Involvement ◽  
Peripheral Nerve Involvement
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