scholarly journals Efficacy and safety of treatment for Old World cutaneous leishmaniasis in pediatric patients: a case series

2021 ◽  
Author(s):  
Tomàs Boal Cunha ◽  
Thomas Bieber ◽  
Ingrid Reiter‐Owona ◽  
Jörg Wenzel ◽  
Julia Altengarten ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Pediatric Patients ◽  
Case Series ◽  
Efficacy And Safety ◽  
Old World

scholarly journals 766. Everything Old is New Again-A Case Series of New World Leishmaniasis in African Children in Portland, Maine

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S428-S428
Author(s):  
Jennifer Jubulis ◽  
Amanda Goddard ◽  
Elizabeth Seiverling ◽  
Marc Kimball ◽  
Carol A McCarthy
Keyword(s):  
Latin America ◽  
Cutaneous Leishmaniasis ◽  
New World ◽  
Pediatric Patients ◽  
Data Extraction ◽  
Clinical Manifestations ◽  
Case Series ◽  
Surgical Excision ◽  
Skin Lesions ◽  
Travel History

Abstract Background Leishmaniasis has many clinical manifestations and treatment regimens, dependent on species and host. Old world leishmaniasis is found primarily in Africa and Asia, and is associated with visceral disease, while new world disease, seen primarily in Latin America, is more commonly mucocutaneous. We present a case series of pediatric African patients with New World cutaneous leishmaniasis (NWCL). Methods Data extraction was performed via chart review, analyzing travel history, clinical presentation, diagnosis, and management in children with cutaneous leishmaniasis presenting to the pediatric infectious diseases clinic in Portland, ME. Biopsy specimens were sent to the federal CDC for identification by PCR and culture. Results Five cases of NWCL were diagnosed in pediatric patients in Maine from November 2018 through February 2020. Median age of patients was 10 years (range 1.5-15 years). Four cases (80%) occurred in children from Angola or Democratic Republic of Congo, arriving in Maine via Central/South America, with one case in a child from Rwanda who arrived in Maine via Texas. Three patients had multiple skin lesions and two had isolated facial lesions. Leishmaniasis was not initially suspected resulting in median time to diagnosis of 5 months (range 1-7 months). Four patients were initially treated with antibacterials for cellulitis and one was treated with griseofulvin. After no improvement, patients underwent biopsy with 2 patients diagnosed with L panamensis, 1 with L braziliensis, 1 with mixed infection (L panamensis and L mexicana), and 1 with Leishmania species only. One patient was managed with surgical excision, 3 with ketoconazole, and 1 was observed off therapy. Four patients were referred to otolaryngology. All continue to be followed in infectious disease clinic. Conclusion We present five cases of new world cutaneous leishmaniasis in African pediatric patients arriving to Maine through Latin America or Texas. Patients were diagnosed with cellulitis, tinea corporis or atopic dermatitis initially, underscoring importance of high index of suspicion in migrant patients. Detailed travel history and epidemiologic knowledge is essential to diagnosis, as patients may present with illness not congruent with country of origin. Optimal therapy remains unclear. Disclosures All Authors: No reported disclosures

Efficacy of erbium glass laser in the treatment of Old World cutaneous leishmaniasis: A case series

2018 ◽  
Vol 60 (1) ◽  
pp. e29-e32 ◽  
Author(s):  
Vahid Mashayekhi Goyonlo ◽  
Mahboubeh Karrabi ◽  
Bita Kiafar
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Case Series ◽  
Glass Laser ◽  
Old World ◽  
Erbium Glass

Pediatric Old World cutaneous leishmaniasis treated with oral fluconazole: A case series

2018 ◽  
Vol 35 (3) ◽  
pp. 384-387 ◽  
Author(s):  
Andrea Michelerio ◽  
Stefania Barruscotti ◽  
Grazia Bossi ◽  
Valeria Brazzelli
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Case Series ◽  
Oral Fluconazole ◽  
Old World

Efficacy and safety of omalizumab in pediatric patients with high immunoglobulin E levels: A case series

2018 ◽  
Vol 39 (4) ◽  
pp. 289-291 ◽  
Author(s):  
Kathleen Y. Wang ◽  
Sayantani B. Sindher ◽  
Rosemary Stinson ◽  
Sigrid Payne DaVeiga
Keyword(s):  
Pediatric Patients ◽  
Immunoglobulin E ◽  
Case Series ◽  
Efficacy And Safety

scholarly journals Case Series: Efficacy and Safety of Hemoadsorption With HA-330 Adsorber in Septic Pediatric Patients With Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Vitaliy Sazonov ◽  
Ramazan Abylkassov ◽  
Zaure Tobylbayeva ◽  
Askhat Saparov ◽  
Olga Mironova ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Pediatric Patients ◽  
Case Series ◽  
Adjunctive Treatment ◽  
Efficacy And Safety ◽  
Hematological Disorders ◽  
Patients With Cancer ◽  
Extracorporeal Blood Purification ◽  
Blood Purification Therapy ◽  
Appropriate Therapy

Background: Sepsis is a frequent cause of death in hospitalized patients and, in detail, in neonatal, pediatric, and adult intensive care units (ICUs). Severe sepsis has a very poor prognosis. Indeed, the mortality rate varies between 30 and 70% during the first 7–14 days. Despite a timely and appropriate therapy, the prognosis of severe sepsis is too often negative. Therefore, new therapeutic resources are under investigation in order to further improve prognosis.Case series: Here, we reported three septic children in whom we used extracorporeal blood purification therapy with hemoadsorption device HA330 (Jafron Biomedical Co., Ltd., China), aiming to scavenge and eliminate bacterial toxins and inflammatory mediators from the blood.Discussion and Conclusion: This small case series first showed that hemoperfusion with HA330 cartridge may be an effective and relatively safe adjunctive treatment to counterbalance the cytokine storm in septic children with hematological disorders. Further studies are needed to confirm and further support its safety and efficacy in a large number of pediatric patients.

scholarly journals Miltefosine for Mucosal and Complicated Cutaneous Old World Leishmaniasis: A Case Series and Review of the Literature

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
Vincent Mosimann ◽  
Claudia Blazek ◽  
Heini Grob ◽  
Matthew Chaney ◽  
Andreas Neumayr ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Cutaneous Leishmaniasis ◽  
Clinical Studies ◽  
Systemic Treatment ◽  
Treatment Options ◽  
Case Series ◽  
Review Of The Literature ◽  
Effective Treatment Option ◽  
Old World ◽  
Mucosal Leishmaniasis

Abstract Complicated Old World cutaneous leishmaniasis (OWCL) and Old World mucosal leishmaniasis (OWML) constitute an indication for systemic treatment. To date, there no controlled clinical studies that compare treatment options for these diseases. We compiled a case series of 24 cases successfully treated with miltefosine. We conclude that oral miltefosine is an effective treatment option for both OWCL and OWML.

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