scholarly journals Miltefosine for Mucosal and Complicated Cutaneous Old World Leishmaniasis: A Case Series and Review of the Literature

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
Vincent Mosimann ◽  
Claudia Blazek ◽  
Heini Grob ◽  
Matthew Chaney ◽  
Andreas Neumayr ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Cutaneous Leishmaniasis ◽  
Clinical Studies ◽  
Systemic Treatment ◽  
Treatment Options ◽  
Case Series ◽  
Review Of The Literature ◽  
Effective Treatment Option ◽  
Old World ◽  
Mucosal Leishmaniasis

Abstract Complicated Old World cutaneous leishmaniasis (OWCL) and Old World mucosal leishmaniasis (OWML) constitute an indication for systemic treatment. To date, there no controlled clinical studies that compare treatment options for these diseases. We compiled a case series of 24 cases successfully treated with miltefosine. We conclude that oral miltefosine is an effective treatment option for both OWCL and OWML.

scholarly journals Sclerosing Mesenteritis: Diverse clinical presentations and dissimilar treatment options. A case series and review of the literature

2011 ◽  
Vol 4 (1) ◽  
pp. 17 ◽  
Author(s):  
Konstantinos Vlachos ◽  
Fotis Archontovasilis ◽  
Evangelos Falidas ◽  
Stavros Mathioulakis ◽  
Stefanos Konstandoudakis ◽  
...  
Keyword(s):  
Treatment Options ◽  
Case Series ◽  
Sclerosing Mesenteritis ◽  
Review Of The Literature ◽  
Clinical Presentations

Efficacy of erbium glass laser in the treatment of Old World cutaneous leishmaniasis: A case series

2018 ◽  
Vol 60 (1) ◽  
pp. e29-e32 ◽  
Author(s):  
Vahid Mashayekhi Goyonlo ◽  
Mahboubeh Karrabi ◽  
Bita Kiafar
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Case Series ◽  
Glass Laser ◽  
Old World ◽  
Erbium Glass

Pharmacological treatment of hepatocellular carcinoma with cavoatrial tumor thrombus – case series and literature review

2019 ◽  
Vol 57 (04) ◽  
pp. 501-507 ◽  
Author(s):  
Tianzuo Zhan ◽  
Janina Sollors ◽  
Niels Steinebrunner ◽  
Hans Schlitt ◽  
Christian Stroszczynski ◽  
...  
Keyword(s):  
Tumor Thrombus ◽  
Systemic Treatment ◽  
Treatment Options ◽  
Survival Rates ◽  
Vena Cava ◽  
Case Series ◽  
Surgical Approaches ◽  
Surgical Interventions ◽  
Advanced Hcc ◽  
Multimodal Therapy Concept

AbstractHepatocellular carcinomas (HCC) that extend into the vena cava and the right atrium have a poor prognosis. Surgical approaches including partial hepatectomy and thrombectomy are the most frequently reported treatment options. However, most patients with advanced HCC are not eligible for complex surgical interventions due to reduced liver function, comorbidities, and metastases. At the same time, systemic treatment options of HCC have expanded in recent years. Here, we report 3 cases of patients with advanced HCC who developed a cavoatrial tumor thrombus (CATT) after initial surgical or interventional therapy. The patients were consequently treated with sorafenib or nivolumab. In all cases, the tumor responded to systemic treatment with disease stabilization or partial regression. Overall survival after diagnosis of CATT was 3 and 17 months for sorafenib and 7 + months for nivolumab. Compared to survival rates of alternative treatment options, systemic therapies demonstrated comparable outcomes. In summary, pharmacotherapy is an efficient and well worth option to treat patients with HCC and CATT and should be an integral part of a multimodal therapy concept.

scholarly journals Ultrasonic Tenotomy and Debridement for Calcific Tendinopathy of the Shoulder: A Pilot Case Series

2020 ◽  
Vol 11 ◽  
pp. 215013272096466
Author(s):  
Jacob L. Erickson ◽  
Andrew R. Jagim
Keyword(s):  
Rotator Cuff ◽  
Sports Medicine ◽  
Treatment Options ◽  
Case Series ◽  
Invasive Treatment ◽  
Effective Treatment Option ◽  
Current Case ◽  
Calcific Tendinopathy ◽  
Pain Scores ◽  
Post Procedure

Calcific tendinopathy of the rotator cuff is a common cause of shoulder pain and debility. Minimally invasive treatment options have been employed for management; however, ultrasonic tenotomy has not been previously described for management of calcific tendinopathy of the shoulder. The purpose of the current case series was to provide preliminary evidence in support of a novel treatment modality for calcific tendinopathy of the rotator cuff. This descriptive pilot case series included a total of 8 patients with calcific tendinopathy of the supraspinatus that underwent ultrasound-guided ultrasonic debridement in the sports medicine clinic. All procedures were performed by the same physician (JLE). All patients had confirmation of the diagnosis with MRI and ultrasound imaging. Pain was measured pre-procedure and followed until 3-months post-procedure. Very large, statistically significant, reductions (P < .01) in pain scores were observed at 1 (ES = 1.93), 2 (ES = 1.84) and 3 (ES = 2.20) months post-procedure, respectively. All patients experienced a significant reduction in pain scores, regardless of hardness of the calcium deposit, at 1 month post-procedure with pain scores remaining lower than at baseline at 2 and 3 months post-procedure. No adverse events were noted in any patients. Ultrasonic tenotomy and debridement appears to be a safe and effective treatment option for patients with calcific tendinopathy of the supraspinatus.

Pediatric Old World cutaneous leishmaniasis treated with oral fluconazole: A case series

2018 ◽  
Vol 35 (3) ◽  
pp. 384-387 ◽  
Author(s):  
Andrea Michelerio ◽  
Stefania Barruscotti ◽  
Grazia Bossi ◽  
Valeria Brazzelli
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Case Series ◽  
Oral Fluconazole ◽  
Old World

scholarly journals Omalizumab Treatment in Chronic Spontaneous Urticaria During Pregnancy: Report of A Case and Review of the Literature

2021 ◽  
Vol 19 (2) ◽  
pp. 114-117
Author(s):  
Andac Salman ◽  
Meryem Aktaş
Keyword(s):  
Pregnant Woman ◽  
Cohort Studies ◽  
Effective Treatment ◽  
Treatment Option ◽  
Congenital Abnormalities ◽  
Chronic Spontaneous Urticaria ◽  
Review Of The Literature ◽  
Effective Treatment Option ◽  
Increased Risk

ABSTRACT Omalizumab is a safe and effective treatment option for chronic spontaneous urticaria (CSU). Although cohort studies in patients with asthma show no increased risk of congenital abnormalities, very little data exist in the literature regarding the use of omalizumab for CSU during pregnancy. Herein, the safe and successful use of omalizumab updosing in a pregnant woman with CSU along with a review of the published literature is presented. Keywords: Chronic spontaneous urticaria, omalizumab, pregnancy, updosing

Pharmacotherapy for Choroidal Neovascularization Due to Uncommon Causes

2019 ◽  
Vol 24 (41) ◽  
pp. 4882-4895
Author(s):  
Christine P.S. Ho ◽  
Timothy Y.Y. Lai
Keyword(s):  
Effective Treatment ◽  
Choroidal Neovascularization ◽  
Case Series ◽  
Subretinal Fluid ◽  
Age Related Macular Degeneration ◽  
Pathologic Myopia ◽  
Effective Treatment Option ◽  
Anti Vegf ◽  
Age Related ◽  
Endothelial Growth Factor

Background: Choroidal neovascularization (CNV) in adults is most commonly associated with neovascular age-related macular degeneration (AMD) and pathologic myopia. Though less common, CNV can also develop from other conditions such as uveitis, central serous chorioretinopathy, angioid streaks, intraocular tumors, hereditary chorioretinal dystrophies, or can be idiopathic in origin. If left untreated, CNV may cause visual loss because of exudation of intraretinal or subretinal fluid, retinal or subretinal hemorrhage, or fibrosis involving the macula. It is well known that one of the main drivers of angiogenesis in CNV development is vascular endothelial growth factor (VEGF) and therefore inhibitors of VEGF might be an effective treatment for CNV. Methods: The goal of this review is to provide an overview and summary in the use of pharmacotherapy especially anti-VEGF therapy, in the treatment of CNV due to uncommon causes. Results: Results from uncontrolled case series and controlled clinical trials have reported good efficacy and safety in using anti-VEGF agents including bevacizumab, ranibizumab, aflibercept and ziv-aflibercept in the treatment of CNV due to uncommon causes. Anti-VEGF has also been used in combination with verteporfin PDT and anti-inflammatory agents for treating CNV of various causes. Conclusion: Pharmacotherapy with anti-VEGF agents is an effective treatment option for CNV due to uncommon etiologies.

Local or systemic treatment for New World cutaneous leishmaniasis? Re-evaluating the evidence for the risk of mucosal leishmaniasis

2012 ◽  
Vol 4 (3) ◽  
pp. 153-163 ◽  
Author(s):  
Johannes Blum ◽  
Diana N.J. Lockwood ◽  
Leo Visser ◽  
Gundel Harms ◽  
Mark S. Bailey ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
New World ◽  
Systemic Treatment ◽  
Mucosal Leishmaniasis

Displaced Acetabular Fracture in Elderly Patients: Is Acute Arthroplasty an Effective Option?

2019 ◽  
Vol 157 (06) ◽  
pp. 676-683 ◽  
Author(s):  
Zhengming Yang ◽  
Stephan Maximillian Röhrl ◽  
Lars Nordsletten
Keyword(s):  
Systematic Review ◽  
Elderly Patients ◽  
Acetabular Fracture ◽  
Treatment Options ◽  
Treatment Recommendation ◽  
Acetabular Fractures ◽  
Review Of The Literature ◽  
Effective Treatment Option ◽  
Elderly Individuals ◽  
Effective Option

Abstract Background and study aim Elderly individuals are the most rapidly growing subgroup of patients currently sustaining acetabular fractures, and total hip arthroplasty (THA) is being applied more and more in the treatment of acetabular fractures. The purpose of this study was to review the available literature regarding displaced acetabular fractures in elderly patients treated with acute THA. Study design A search was conducted using the electronic databases Medline, PubMed, ISI Web of Knowledge, and Scopus on papers published between January 1960 and November 2018 using the terms “acetabular fracture” plus “elderly patients” plus “arthroplasty”. A systematic review of the literature on the different treatment options for acute THA is presented. Results The search yielded a total of 320 articles, and 9 articles were selected for review. The indications, techniques, approaches, and complications of THA are discussed, and a treatment recommendation based on the selected articles is given. Conclusion We consider acute arthroplasty an effective treatment option for displaced acetabular fractures in elderly patients, while different techniques should be used for different displaced acetabular fractures in this patient group.

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