First-episode psychosis is associated with oxidative stress: Effects of short-term antipsychotic treatment

2015 ◽  
Vol 69 (11) ◽  
pp. 699-707 ◽  
Author(s):  
Asli Sarandol ◽  
Emre Sarandol ◽  
Hacer Ebru Acikgoz ◽  
Salih Saygin Eker ◽  
Cengiz Akkaya ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
First Episode Psychosis ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
Short Term ◽  
Stress Effects ◽  
Episode Psychosis

scholarly journals Antipsychotic Treatment Reduces Indices of Oxidative Stress in First-Episode Psychosis Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Kärt Kriisa ◽  
Liina Haring ◽  
Eero Vasar ◽  
Kati Koido ◽  
Sven Janno ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
First Episode Psychosis ◽  
Stress Index ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
High Grade ◽  
Control Subjects ◽  
Episode Psychosis ◽  
Before And After ◽  
The Impact

38 first-episode psychosis (FEP) patients and 37 control subjects were recruited for the study of indices of oxidative stress (OxS). The main purpose of the study was to compare the OxS statuses (serum total antioxidant capacity (TAC), total level of peroxides (TPX), oxidative stress index (OSI), and ratio oxidized methionine (Met-SO) to methionine (Met)) between antipsychotic-naïve FEP patients and individuals without a history of psychiatric disorders. Subsequently, the impact of 7-month antipsychotic treatment was evaluated on the OxS status in FEP patients. An attempt was made to assess links between OxS signature and inflammation markers. The oxidative stress indices remained generally unchanged in antipsychotic-naïve FEP patients compared to control subjects. Despite that, there was a significant correlation between the levels of TPX and EGF (endothelial growth factor) in FEP patients. This correlation disappeared after antipsychotic treatment of FEP patients. Moreover, antipsychotic treatment was associated with a significant reduction in OxS indices, including TPX, OSI, and ratio between Met-SO and Met. By contrast, in chronic SCZ patients we established a significant high-grade OxS. In conclusion, the markers of total antioxidative capacity, lipid peroxidation, and protein oxidation revealed no high-grade OxS in FEP patients. Nevertheless, antipsychotic treatment induced a considerable anti-inflammatory effect. OxS levels were also significantly decreased if compared in FEP patients before and after antipsychotic treatment.

Social Cognitive Markers of Short-Term Clinical Outcome in First-Episode Psychosis

2010 ◽  
Vol 4 (2) ◽  
pp. 105-114 ◽  
Author(s):  
Tina Montreuil ◽  
Michael Bodnar ◽  
Marie-Claude Bertrand ◽  
Ashok Malla ◽  
Ridha Joober ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Social Cognitive ◽  
First Episode Psychosis ◽  
First Episode ◽  
Short Term ◽  
Cognitive Markers ◽  
Episode Psychosis

scholarly journals Treatment response after 6 and 26 weeks is related to baseline glutamate and GABA levels in antipsychotic-naïve patients with psychosis

2019 ◽  
Vol 50 (13) ◽  
pp. 2182-2193 ◽  
Author(s):  
Kirsten B. Bojesen ◽  
Bjørn H. Ebdrup ◽  
Kasper Jessen ◽  
Anne Sigvard ◽  
Karen Tangmose ◽  
...  
Keyword(s):  
Psychotic Disorders ◽  
Poor Response ◽  
First Episode Psychosis ◽  
Anterior Cingulate ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
Resonance Spectroscopy ◽  
Reference Levels ◽  
Clinical Prognosis ◽  
Episode Psychosis

AbstractBackgroundPoor response to dopaminergic antipsychotics constitutes a major challenge in the treatment of psychotic disorders and markers for non-response during first-episode are warranted. Previous studies have found increased levels of glutamate and γ-aminobutyric acid (GABA) in non-responding first-episode patients compared to responders, but it is unknown if non-responders can be identified using reference levels from healthy controls (HCs).MethodsThirty-nine antipsychotic-naïve patients with first-episode psychosis and 36 matched HCs underwent repeated assessments with the Positive and Negative Syndrome Scale and 3T magnetic resonance spectroscopy. Glutamate scaled to total creatine (/Cr) was measured in the anterior cingulate cortex (ACC) and left thalamus, and levels of GABA/Cr were measured in ACC. After 6 weeks, we re-examined 32 patients on aripiprazole monotherapy and 35 HCs, and after 26 weeks we re-examined 30 patients on naturalistic antipsychotic treatment and 32 HCs. The Andreasen criteria defined non-response.ResultsBefore treatment, thalamic glutamate/Cr was higher in the whole group of patients but levels normalized after treatment. ACC levels of glutamate/Cr and GABA/Cr were lower at all assessments and unaffected by treatment. When compared with HCs, non-responders at week 6 (19 patients) and week 26 (16 patients) had higher baseline glutamate/Cr in the thalamus. Moreover, non-responders at 26 weeks had lower baseline GABA/Cr in ACC. Baseline levels in responders and HCs did not differ.ConclusionGlutamatergic and GABAergic abnormalities in antipsychotic-naïve patients appear driven by non-responders to antipsychotic treatment. If replicated, normative reference levels for glutamate and GABA may aid estimation of clinical prognosis in first-episode psychosis patients.

Oxidative Stress and DNA Damage in Untreated First-Episode Psychosis in Adolescents

2016 ◽  
Vol 73 (2) ◽  
pp. 92-97 ◽  
Author(s):  
Şeref Şimşek ◽  
Salih Gençoğlan ◽  
Tuğba Yüksel ◽  
İbrahim Kaplan ◽  
Rümeysa Alaca ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis

scholarly journals Does food responsiveness change in people with first episode psychosis (FEP) over a period of 6 months after commencing antipsychotics? Preliminary results

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S255-S255
Author(s):  
Adrian Heald ◽  
Mark Shakespeare ◽  
Kevin Williamson ◽  
Adrianne Close ◽  
Adrian Phillipson ◽  
...  
Keyword(s):  
Rating Scales ◽  
Eating Behaviour ◽  
First Episode Psychosis ◽  
Intuitive Eating ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
Loss Of Control ◽  
Convenience Sample ◽  
Preliminary Results ◽  
Episode Psychosis

AimsWe here present preliminary results from our study to understand better the changes in people’ s experience of food in the months after diagnosis with first episode psychosis (FEP). Weight gain often occurs in the weeks/months after diagnosis and is related to an increase in appetite and food intake. Many drugs that are effective in treating psychosis are associated with changes in the way that people experience reward when they eat.The aim of this project is to increase our understanding of exactly why this happens in terms of an individual's experience of food reward and reduced satiety – and therefore how we can help people with FEP to keep their weight down. At this stage we are looking at the feasibility of applying currently available evaluation tools to people in this situation.MethodA convenience sample was used to recruit 10 service users from RDaSH NHS FT Early Intervention Services. This is a feasibility study which will provide data to underpin a fully powered, larger trial.Rating scales applied were:Power of food questionnaire: measures responsiveness to the food environment.Intuitive Eating Scale: measures an individual's tendency to follow their physical hunger and satiety cues.The loss of control over eating scale (LOCES): measures a global sense of whether individuals experience LOC over eating.Dutch Eating Behaviour Questionnaire (DEBQ): measures restrained eating, emotional eating and external eating.ResultThe ages of the participants ranged from 17-26 years. All were started on Olanzapine at the dose of 5 or 10 mg daily.Baseline total scores for the Power of Food (2.47-3.80)/5 (higher score = more responsiveness) and Intuitive Eating scales (2.10-2.62)/5 (higher score = greater tendency to follow hunger and satiety cues) were in the mid-range, while the LOCES scores varied widely from 1.50-2.38/5.The DEBQ restrained subscale score range was 2.40-2.80/5 (higher indicates greater restraint with food) while the DEBQ external subscale ranged from 2.70—3.00/5 (higher = greater tendency to overeat) and the DEBQ emotional subtotal score was 1.92-1.94/5, in keeping with a relatively low emotional drive to eat.ConclusionOur preliminary results reveal at the beginning of antipsychotic treatment a moderate responsiveness to food and tendency to follow hunger/ satiety cues, with scores for Loss of Control of eating in the low to moderate range and a low emotional drive to eat. The difference between these and the follow-up eating behaviour scores will provide important clues as to the precise changes in eating behaviour with anti-psychotic treatment in FEP.

scholarly journals Short-term outcome of substance-induced psychotic disorder in a large UK first episode psychosis cohort

2016 ◽  
Vol 134 (4) ◽  
pp. 321-328 ◽  
Author(s):  
A. Thompson ◽  
S. Marwaha ◽  
C. Winsper ◽  
L. Everard ◽  
P. B. Jones ◽  
...  
Keyword(s):  
Psychotic Disorder ◽  
First Episode Psychosis ◽  
First Episode ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome ◽  
Episode Psychosis

Trajectories after first-episode psychosis: Complement to ambiguous outcomes of long-term antipsychotic treatment by exploring a few hidden cases

2018 ◽  
Vol 13 (4) ◽  
pp. 895-901 ◽  
Author(s):  
Chen-Chung Liu ◽  
Yi-Ting Lin ◽  
Chih-Min Liu ◽  
Ming H. Hsieh ◽  
Yi-Ling Chien ◽  
...  
Keyword(s):  
First Episode Psychosis ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
Episode Psychosis
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