Oxidative Stress and DNA Damage in Untreated First-Episode Psychosis in Adolescents

2016 ◽  
Vol 73 (2) ◽  
pp. 92-97 ◽  
Author(s):  
Şeref Şimşek ◽  
Salih Gençoğlan ◽  
Tuğba Yüksel ◽  
İbrahim Kaplan ◽  
Rümeysa Alaca ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis

scholarly journals Oxidative Stress and Inflammation in First-Episode Psychosis: A Systematic Review and Meta-analysis

2018 ◽  
Vol 45 (4) ◽  
pp. 742-751 ◽  
Author(s):  
David Fraguas ◽  
Covadonga M Díaz-Caneja ◽  
Miriam Ayora ◽  
Fabián Hernández-Álvarez ◽  
Alberto Rodríguez-Quiroga ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Meta Analysis ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis

First-episode psychosis is associated with oxidative stress: Effects of short-term antipsychotic treatment

2015 ◽  
Vol 69 (11) ◽  
pp. 699-707 ◽  
Author(s):  
Asli Sarandol ◽  
Emre Sarandol ◽  
Hacer Ebru Acikgoz ◽  
Salih Saygin Eker ◽  
Cengiz Akkaya ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
First Episode Psychosis ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
Short Term ◽  
Stress Effects ◽  
Episode Psychosis

Oxidative stress, inflammation and cognitive impairment in first psychotic patients

2011 ◽  
Vol 26 (S2) ◽  
pp. 427-427
Author(s):  
M. Martínez-Cengotitabengoa ◽  
J.C. Leza ◽  
S. Alberich ◽  
S. Barbeito ◽  
R. González-Oliveros ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Cognitive Impairment ◽  
Cognitive Functioning ◽  
Verbal Memory ◽  
First Episode Psychosis ◽  
First Episode ◽  
Healthy Controls ◽  
Episode Psychosis ◽  
Activity Of Enzymes

IntroductionBoth oxidative stress and the inflammatory chemokine MCP-1 have been linked to the pathophysiology of certain mental illnesses such as psychosis. There are previous studies in rats and dogs suggesting that oxidative stress can cause cognitive impairment.ObjectivesTo correlate oxidative stress and the chemokine MCP-1 levels with cognitive impairment in first episode psychosis.Methods28 patients with first episode psychosis and 28 healthy controls matched by sex and age were included in the study, who were given a battery of neurocognitive tests and we determined their blood levels of lipid peroxidation (TBARS), nitric oxide, total antioxidant status (TAS), glutathione, activity of enzymes catalase (CAT), glutathione peroxidase (cGPx) and superoxide dismutase (SOD) and the inflammatory chemokine MCP-1.ResultsHealthy controls had better TAS than patients and increased activity of enzymes cGPx and CAT.We found a statistically significant negative relationship between levels of MCP-1 and working memory, attention and verbal memory. At higher levels of chemokines, worse cognitive functioning in these areas.Verbal memory was also negatively related, in a meaningful way, with nitric oxide levels in blood.Likewise, we found that higher levels of glutathione correlated with better scores on the 3 tests performed of verbal fluency.ConclusionsIn patients with a PEP, levels of certain markers of oxidative stress and inflammation are associated with poorer cognitive functioning.

scholarly journals Antipsychotic Treatment Reduces Indices of Oxidative Stress in First-Episode Psychosis Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Kärt Kriisa ◽  
Liina Haring ◽  
Eero Vasar ◽  
Kati Koido ◽  
Sven Janno ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
First Episode Psychosis ◽  
Stress Index ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
High Grade ◽  
Control Subjects ◽  
Episode Psychosis ◽  
Before And After ◽  
The Impact

38 first-episode psychosis (FEP) patients and 37 control subjects were recruited for the study of indices of oxidative stress (OxS). The main purpose of the study was to compare the OxS statuses (serum total antioxidant capacity (TAC), total level of peroxides (TPX), oxidative stress index (OSI), and ratio oxidized methionine (Met-SO) to methionine (Met)) between antipsychotic-naïve FEP patients and individuals without a history of psychiatric disorders. Subsequently, the impact of 7-month antipsychotic treatment was evaluated on the OxS status in FEP patients. An attempt was made to assess links between OxS signature and inflammation markers. The oxidative stress indices remained generally unchanged in antipsychotic-naïve FEP patients compared to control subjects. Despite that, there was a significant correlation between the levels of TPX and EGF (endothelial growth factor) in FEP patients. This correlation disappeared after antipsychotic treatment of FEP patients. Moreover, antipsychotic treatment was associated with a significant reduction in OxS indices, including TPX, OSI, and ratio between Met-SO and Met. By contrast, in chronic SCZ patients we established a significant high-grade OxS. In conclusion, the markers of total antioxidative capacity, lipid peroxidation, and protein oxidation revealed no high-grade OxS in FEP patients. Nevertheless, antipsychotic treatment induced a considerable anti-inflammatory effect. OxS levels were also significantly decreased if compared in FEP patients before and after antipsychotic treatment.

Poster #124 RELATIONSHIP BETWEEN OXIDATIVE STRESS/INFLAMMATION AND COGNITIVE IMPAIRMENT IN FIRST EPISODE PSYCHOSIS

2012 ◽  
Vol 136 ◽  
pp. S230
Author(s):  
Sonia Ruiz de Azua ◽  
Patricia Vega ◽  
Monica Martinez-Cengotitabengoa ◽  
Sara Barbeito ◽  
Belen Garcia-Lecumberri ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cognitive Impairment ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis

Oxidative stress in drug naïve first episode psychosis and antioxidant effects of risperidone

2015 ◽  
Vol 68 ◽  
pp. 210-216 ◽  
Author(s):  
Cristiano Noto ◽  
Vanessa Kiyomi Ota ◽  
Ary Gadelha ◽  
Mariane Nunes Noto ◽  
Décio Sabbatini Barbosa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Drug Naïve ◽  
Antioxidant Effects

scholarly journals Central oxidative stress and early vocational outcomes in first episode psychosis: A 7-Tesla Magnetic Resonance Spectroscopy study of glutathione

2021 ◽  
Author(s):  
Michael MacKinley ◽  
Sabrina D. Ford ◽  
Peter Jeon ◽  
Jean Théberge ◽  
Lena Palaniyappan
Keyword(s):  
Oxidative Stress ◽  
Magnetic Resonance ◽  
Functional Outcomes ◽  
First Episode Psychosis ◽  
7 Tesla ◽  
First Episode ◽  
Resonance Spectroscopy ◽  
Healthy Controls ◽  
Episode Psychosis ◽  
Employment Education

ABSTRACTFollowing the first episode of psychosis, some patients develop poor social and occupational outcomes, while others display a pattern of preserved functioning. Several lines of evidence from preclinical, genetic and biochemical studies suggest a role for high oxidative stress in poor functional outcomes. The measurement of intracortical glutathione (GSH) using magnetic resonance spectroscopy (MRS) provides an opportunity to investigate the relationship between central antioxidant tone and functional outcomes at the time of first episode psychosis (FEP). A body of epidemiological studies indicates better functional outcomes in patients at early stages of schizophrenia compared to patients at a chronic, established phase of illness. We scanned 57 patients with FEP and 30 matched healthy controls and estimated GSH resonance using 7-Tesla MRS. We minimised the confounding effects of illness chronicity, long-term treatment exposure and metabolic complications by recruiting patients with <2 weeks of lifetime antipsychotic exposure on average and followed up this cohort for the next 1 year to determine functional outcomes. Patients with FEP who achieved employment/education or training status (EET) in the first year, had higher GSH at the baseline than healthy controls. Social and occupational functioning assessment scale (SOFAS) scores were also significantly higher in patients with higher GSH levels at the outset, after adjusting for various confounds including baseline SOFAS. Patients who were not in employment, education or training (NEET) did not differ from healthy subjects in their GSH levels. Our observations support a key role for the central antioxidant tone in the functional outcomes of early psychosis.

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