scholarly journals Short-term outcome of substance-induced psychotic disorder in a large UK first episode psychosis cohort

2016 ◽  
Vol 134 (4) ◽  
pp. 321-328 ◽  
Author(s):  
A. Thompson ◽  
S. Marwaha ◽  
C. Winsper ◽  
L. Everard ◽  
P. B. Jones ◽  
...  
Keyword(s):  
Psychotic Disorder ◽  
First Episode Psychosis ◽  
First Episode ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome ◽  
Episode Psychosis

Cannabis use in children and adolescents with first episode psychosis: Influence on psychopathology and short-term outcome (CAFEPS study)

2009 ◽  
Vol 113 (2-3) ◽  
pp. 129-137 ◽  
Author(s):  
Immaculada Baeza ◽  
Montserrat Graell ◽  
Dolores Moreno ◽  
Josefina Castro-Fornieles ◽  
Mara Parellada ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
First Episode Psychosis ◽  
Cannabis Use ◽  
First Episode ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome ◽  
Episode Psychosis

0103 PHOSPHOLIPASE-A2 ACTIVITY PREDICTS SHORT-TERM OUTCOME IN FIRST EPISODE PSYCHOSIS

2006 ◽  
Vol 86 ◽  
pp. S69-S70
Author(s):  
Y. Yun ◽  
G. Berger ◽  
S. Smesny ◽  
M. Law ◽  
T.-M. Proffitt ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
First Episode Psychosis ◽  
First Episode ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome ◽  
Episode Psychosis ◽  
Phospholipase A2 Activity

Fronto-temporal disconnectivity and clinical short-term outcome in first episode psychosis: A DTI-tractography study

2011 ◽  
Vol 45 (3) ◽  
pp. 369-377 ◽  
Author(s):  
David Luck ◽  
Lisa Buchy ◽  
Yvonne Czechowska ◽  
Michael Bodnar ◽  
G. Bruce Pike ◽  
...  
Keyword(s):  
First Episode Psychosis ◽  
First Episode ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome ◽  
Episode Psychosis ◽  
Dti Tractography

scholarly journals Impact of persistent substance misuse on 1-year outcome in first-episode psychosis

2009 ◽  
Vol 195 (3) ◽  
pp. 242-248 ◽  
Author(s):  
Aidan Turkington ◽  
Ciaran C. Mulholland ◽  
Teresa M. Rushe ◽  
Rick Anderson ◽  
Rosalind McCaul ◽  
...  
Keyword(s):  
Substance Misuse ◽  
Severe Depression ◽  
First Episode Psychosis ◽  
First Episode ◽  
Short Term ◽  
Term Outcome ◽  
Clinical Assessments ◽  
Assessment Period ◽  
Episode Psychosis ◽  
Baseline Characteristics

BackgroundSubstance misuse is a common comorbid problem in people presenting with first-episode psychosis and is associated with a poor short-term outcome.AimsThe aim of this study is to examine differences in baseline characteristics and 1-year outcome between individuals with first-episode psychosis who have never misused substances, those who stop misusing substances after initial presentation and those who persistently misuse substances over the 1-year assessment period.MethodPatients were recruited to the Northern Ireland First Episode Psychosis Study (n = 272). Clinical assessments were performed at baseline and at 1 year (n = 194) and data were collected from the case notes.ResultsIndividuals with persistent substance misuse had more severe depression, more positive symptoms, poorer functional outcome and greater rates of relapse at 1 year than those who stopped and those who had never misused substances. There were no differences in outcome between people who had never misused substances and those who stopped misusing after presentation.These results support assertive intervention targeted at comorbid substance misuse in individuals with first-episode psychosis.

Social Cognitive Markers of Short-Term Clinical Outcome in First-Episode Psychosis

2010 ◽  
Vol 4 (2) ◽  
pp. 105-114 ◽  
Author(s):  
Tina Montreuil ◽  
Michael Bodnar ◽  
Marie-Claude Bertrand ◽  
Ashok Malla ◽  
Ridha Joober ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Social Cognitive ◽  
First Episode Psychosis ◽  
First Episode ◽  
Short Term ◽  
Cognitive Markers ◽  
Episode Psychosis

scholarly journals Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis

2021 ◽  
Author(s):  
Meike Heurich ◽  
Melanie Föcking ◽  
David Mongan ◽  
Gerard Cagney ◽  
David R. Cotter
Keyword(s):  
High Risk ◽  
Psychotic Disorder ◽  
Psychotic Disorders ◽  
Clinical Symptoms ◽  
First Episode Psychosis ◽  
Specific Protein ◽  
First Episode ◽  
Clinical High Risk ◽  
Blood Proteins ◽  
Episode Psychosis

AbstractEarly identification and treatment significantly improve clinical outcomes of psychotic disorders. Recent studies identified protein components of the complement and coagulation systems as key pathways implicated in psychosis. These specific protein alterations are integral to the inflammatory response and can begin years before the onset of clinical symptoms of psychotic disorder. Critically, they have recently been shown to predict the transition from clinical high risk to first-episode psychosis, enabling stratification of individuals who are most likely to transition to psychotic disorder from those who are not. This reinforces the concept that the psychosis spectrum is likely a central nervous system manifestation of systemic changes and highlights the need to investigate plasma proteins as diagnostic or prognostic biomarkers and pathophysiological mediators. In this review, we integrate evidence of alterations in proteins belonging to the complement and coagulation protein systems, including the coagulation, anticoagulation, and fibrinolytic pathways and their dysregulation in psychosis, into a consolidated mechanism that could be integral to the progression and manifestation of psychosis. We consolidate the findings of altered blood proteins relevant for progression to psychotic disorders, using data from longitudinal studies of the general population in addition to clinical high-risk (CHR) individuals transitioning to psychotic disorder. These are compared to markers identified from first-episode psychosis and schizophrenia as well as other psychosis spectrum disorders. We propose the novel hypothesis that altered complement and coagulation plasma levels enhance their pathways’ activating capacities, while low levels observed in key regulatory components contribute to excessive activation observed in patients. This hypothesis will require future testing through a range of experimental paradigms, and if upheld, complement and coagulation pathways or specific proteins could be useful diagnostic or prognostic tools and targets for early intervention and preventive strategies.

Estimating the incidence of first-episode psychosis using population-based health administrative data to inform early psychosis intervention services

2018 ◽  
Vol 49 (12) ◽  
pp. 2091-2099 ◽  
Author(s):  
Kelly K. Anderson ◽  
Ross Norman ◽  
Arlene G. MacDougall ◽  
Jordan Edwards ◽  
Lena Palaniyappan ◽  
...  
Keyword(s):  
Psychotic Disorder ◽  
Administrative Data ◽  
Catchment Area ◽  
Population Based ◽  
First Episode Psychosis ◽  
Case Definition ◽  
First Episode ◽  
Affective Psychosis ◽  
Health Administrative Data ◽  
Episode Psychosis

AbstractBackgroundDiscrepancies between population-based estimates of the incidence of psychotic disorder and the treated incidence reported by early psychosis intervention (EPI) programs suggest additional cases may be receiving services elsewhere in the health system. Our objective was to estimate the incidence of non-affective psychotic disorder in the catchment area of an EPI program, and compare this to EPI-treated incidence estimates.MethodsWe constructed a retrospective cohort (1997–2015) of incident cases of non-affective psychosis aged 16–50 years in an EPI program catchment using population-based linked health administrative data. Cases were identified by either one hospitalization or two outpatient physician billings within a 12-month period with a diagnosis of non-affective psychosis. We estimated the cumulative incidence and EPI-treated incidence of non-affective psychosis using denominator data from the census. We also estimated the incidence of first-episode psychosis (people who would meet the case definition for an EPI program) using a novel approach.ResultsOur case definition identified 3245 cases of incident non-affective psychosis over the 17-year period. We estimate that the incidence of first-episode non-affective psychosis in the program catchment area is 33.3 per 100 000 per year (95% CI 31.4–35.1), which is more than twice as high as the EPI-treated incidence of 18.8 per 100 000 per year (95% CI 17.4–20.3).ConclusionsCase ascertainment strategies limited to specialized psychiatric services may substantially underestimate the incidence of non-affective psychotic disorders, relative to population-based estimates. Accurate information on the epidemiology of first-episode psychosis will enable us to more effectively resource EPI services and evaluate their coverage.

Impact of duration of untreated psychosis in short‐term response to treatment and outcome in antipsychotic naïve first‐episode psychosis

2019 ◽  
Vol 14 (6) ◽  
pp. 677-683 ◽  
Author(s):  
Daniel A. Cavalcante ◽  
Luccas S. Coutinho ◽  
Bruno B. Ortiz ◽  
Mariane N. Noto ◽  
Quirino Cordeiro ◽  
...  
Keyword(s):  
First Episode Psychosis ◽  
Response To Treatment ◽  
First Episode ◽  
Duration Of Untreated Psychosis ◽  
Short Term ◽  
Episode Psychosis ◽  
Term Response
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