Physico‐chemical stability of Plasma‐Lyte 148® and Plasma‐Lyte 148® + 5% Glucose with eight common intravenous medications

2019 ◽  
Vol 29 (2) ◽  
pp. 186-192
Author(s):  
Rachael Dawson ◽  
Andrew Wignell ◽  
Paul Cooling ◽  
David Barrett ◽  
Harish Vyas ◽  
...  
Keyword(s):  
Chemical Stability ◽  
Physico Chemical

Physico-chemical stability of casein micelles cross-linked by transglutaminase as a function of acidic pH

2019 ◽  
Vol 19 ◽  
pp. 100103 ◽  
Author(s):  
Márcio H. Nogueira ◽  
Guilherme M. Tavares ◽  
Naaman F. Nogueira Silva ◽  
Federico Casanova ◽  
Paulo C. Stringheta ◽  
...  
Keyword(s):  
Chemical Stability ◽  
Acidic Ph ◽  
Casein Micelles ◽  
Physico Chemical

scholarly journals Evaluations about the physico-chemical stability of docetaxel and irinotecan pre-diluted and diluted solutions: pharmaco-economic perspectives

2013 ◽  
Vol 3 (1) ◽  
pp. 6 ◽  
Author(s):  
Mariarita Laforgia ◽  
Anna Elisa Quatrale ◽  
Nicola A. Colabufo ◽  
Amalia Azzariti ◽  
Angelo Paradiso ◽  
...  
Keyword(s):  
Chemical Stability ◽  
Mobile Phase ◽  
Ammonium Acetate ◽  
Physical Stability ◽  
Experimental Conditions ◽  
Phase Gradient ◽  
Methanol Mixture ◽  
Physico Chemical ◽  
Starting Point ◽  
Economic Perspectives

Several clinically used anticancer drugs are well-known as far as their pharmacologic properties are concerned, but scarcely ever the interest towards their physico-chemical characteristics in solution led to practical acknowledgement in their management. Thanks to the Units for Centralized Anticancer Drug Handling, the importance to evaluate the concentration of saturation (physical stability) or the possible transformations undergone by a drug in solution (chemical stability) has become the starting point for avoiding useless wasting drugs and economic resources. By HPLC experiments we have demonstrated that the solutions of two drugs, docetaxel and irinotecan, are particularly stable at different concentrations and times of analyses in our experimental conditions. The best mobile phase for docetaxel was water/methanol/acetonitrile in 42/32/26 volumetric ratio: for halving concentrations (0.72-0.36-0.18-0.09 mg/mL) in NaCl 0.9%, the highest value gave a six-day and the three lower concentrations a fourteen-day stability, when storage occurred at room temperature and light protected. Elution of irinotecan was possible through an analysis in mobile phase gradient: at t0 a 20% ammonium acetate 10 mM and 80% methanol mixture, and after 5 min, a 80% ammonium acetate 10 mM and 20% methanol mixture. The physico-chemical stability was showed for five days, for any concentration of analysis when storage occurred at 2-8°C and light protected.

scholarly journals Physico-chemical stability of solid surfaces: Final report

1998 ◽  
Author(s):  
T.A. Michalske ◽  
D.R. Jennison ◽  
P.J. Feibelman ◽  
J.E. Houston ◽  
G.L. Kellogg
Keyword(s):  
Chemical Stability ◽  
Solid Surfaces ◽  
Final Report ◽  
Physico Chemical

Metal Ion Leachates and the Physico-Chemical Stability of Biotherapeutic Drug Products

2014 ◽  
Vol 20 (8) ◽  
pp. 1173-1181 ◽  
Author(s):  
Sandeep Kumar ◽  
Shuxia Zhou ◽  
Satish Singh
Keyword(s):  
Chemical Stability ◽  
Metal Ion ◽  
Drug Products ◽  
Physico Chemical

scholarly journals Physico-Chemical Stability of Flaxseed Oil with Natural Antioxidant Mixtures during Heating

2005 ◽  
Vol 54 (2) ◽  
pp. 71-79 ◽  
Author(s):  
Irwandi JASWIR ◽  
David D. KITTS ◽  
Yaakob B. Che MAN ◽  
Torla H. HASSAN
Keyword(s):  
Chemical Stability ◽  
Flaxseed Oil ◽  
Natural Antioxidant ◽  
Physico Chemical
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