scholarly journals Physico-chemical stability of solid surfaces: Final report

1998 ◽  
Author(s):  
T.A. Michalske ◽  
D.R. Jennison ◽  
P.J. Feibelman ◽  
J.E. Houston ◽  
G.L. Kellogg
Keyword(s):  
Chemical Stability ◽  
Solid Surfaces ◽  
Final Report ◽  
Physico Chemical

Enzymes at solid surfaces: Nature of the interfaces and physico-chemical processes

2008 ◽  
Vol 54 (1) ◽  
pp. 116-122 ◽  
Author(s):  
Samuel Caillou ◽  
Patrick A. Gerin ◽  
Cristèle J. Nonckreman ◽  
Sandrine Fleith ◽  
Christine C. Dupont-Gillain ◽  
...  
Keyword(s):  
Chemical Processes ◽  
Solid Surfaces ◽  
Physico Chemical

Physico‐chemical stability of Plasma‐Lyte 148® and Plasma‐Lyte 148® + 5% Glucose with eight common intravenous medications

2019 ◽  
Vol 29 (2) ◽  
pp. 186-192
Author(s):  
Rachael Dawson ◽  
Andrew Wignell ◽  
Paul Cooling ◽  
David Barrett ◽  
Harish Vyas ◽  
...  
Keyword(s):  
Chemical Stability ◽  
Physico Chemical

Physico-chemical stability of casein micelles cross-linked by transglutaminase as a function of acidic pH

2019 ◽  
Vol 19 ◽  
pp. 100103 ◽  
Author(s):  
Márcio H. Nogueira ◽  
Guilherme M. Tavares ◽  
Naaman F. Nogueira Silva ◽  
Federico Casanova ◽  
Paulo C. Stringheta ◽  
...  
Keyword(s):  
Chemical Stability ◽  
Acidic Ph ◽  
Casein Micelles ◽  
Physico Chemical

scholarly journals Evaluations about the physico-chemical stability of docetaxel and irinotecan pre-diluted and diluted solutions: pharmaco-economic perspectives

2013 ◽  
Vol 3 (1) ◽  
pp. 6 ◽  
Author(s):  
Mariarita Laforgia ◽  
Anna Elisa Quatrale ◽  
Nicola A. Colabufo ◽  
Amalia Azzariti ◽  
Angelo Paradiso ◽  
...  
Keyword(s):  
Chemical Stability ◽  
Mobile Phase ◽  
Ammonium Acetate ◽  
Physical Stability ◽  
Experimental Conditions ◽  
Phase Gradient ◽  
Methanol Mixture ◽  
Physico Chemical ◽  
Starting Point ◽  
Economic Perspectives

Several clinically used anticancer drugs are well-known as far as their pharmacologic properties are concerned, but scarcely ever the interest towards their physico-chemical characteristics in solution led to practical acknowledgement in their management. Thanks to the Units for Centralized Anticancer Drug Handling, the importance to evaluate the concentration of saturation (physical stability) or the possible transformations undergone by a drug in solution (chemical stability) has become the starting point for avoiding useless wasting drugs and economic resources. By HPLC experiments we have demonstrated that the solutions of two drugs, docetaxel and irinotecan, are particularly stable at different concentrations and times of analyses in our experimental conditions. The best mobile phase for docetaxel was water/methanol/acetonitrile in 42/32/26 volumetric ratio: for halving concentrations (0.72-0.36-0.18-0.09 mg/mL) in NaCl 0.9%, the highest value gave a six-day and the three lower concentrations a fourteen-day stability, when storage occurred at room temperature and light protected. Elution of irinotecan was possible through an analysis in mobile phase gradient: at t0 a 20% ammonium acetate 10 mM and 80% methanol mixture, and after 5 min, a 80% ammonium acetate 10 mM and 20% methanol mixture. The physico-chemical stability was showed for five days, for any concentration of analysis when storage occurred at 2-8°C and light protected.

scholarly journals Interaction between SARS-CoV-2 spike glycoprotein and human skin models: a molecular dynamics study

2021 ◽  
Author(s):  
Marc Domingo ◽  
Jordi Faraudo
Keyword(s):  
Stratum Corneum ◽  
Human Skin ◽  
Skin Surface ◽  
Viral Envelope ◽  
Solid Surfaces ◽  
Spike Glycoprotein ◽  
Indirect Transmission ◽  
Physico Chemical ◽  
Human Skin Models ◽  
Structure Orientation

The possibility of contamination of human skin by infectious virions plays an important role in indirect transmission of respiratory viruses but little is known about the fundamental physico-chemical aspects of the virus-skin interactions. In the case of coronaviruses, the interaction with surfaces (including the skin surface) is mediated by their large glycoprotein spikes that protrude from (and cover) the viral envelope. Here, we perform all atomic simulations between the SARS-CoV-2 spike glycoprotein and human skin models. We consider an "oily" skin covered by sebum and a "clean" skin exposing the stratum corneum. The simulations show that the spike tries to maximize the contacts with stratum corneum lipids, particularly ceramides, with substantial hydrogen bonding. In the case of "oily" skin, the spike is able to retain its structure, orientation and hydration over sebum with little interaction with sebum components. Comparison of these results with our previous simulations of the interaction of SARS-CoV-2 spike with hydrophilic and hydrophobic solid surfaces, suggests that the"soft" or "hard" nature of the surface plays an essential role in the interaction of the spike protein with materials.

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