Host‐microbial interactions between PTGR2 and Bifidobacterium in the early life gut of atopic dermatitis children

2021 ◽  
Author(s):  
Jeong‐Hyun Kim ◽  
Seung‐Hwa Lee ◽  
Mi‐Jin Kang ◽  
Sun‐Goo Hwang ◽  
Yoon Mee Park ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Early Life ◽  
Microbial Interactions

scholarly journals Using family atopy scores to identify the risk of atopic dermatitis in infants

2014 ◽  
Vol 54 (6) ◽  
pp. 330
Author(s):  
Melisa Anggraeni ◽  
Ketut Dewi Kumara Wati ◽  
Ketut Tangking
Keyword(s):  
Atopic Dermatitis ◽  
Cohort Study ◽  
Pregnant Woman ◽  
Environmental Factors ◽  
Antenatal Care ◽  
Early Life ◽  
Early Interventions ◽  
Chi Square

Background Atopic dermatitis is the first manifestation ofallergic disease in early life. Early interventions may prevent thedevelopment of allergy disease. Allergy trace cards have beenused to identify the level of allergic risk, based on family atopyscores. Because environmental factors may also influence thedevelopment of atopic dermatitis, the usefulness of the allergytrace card needs to be reevaluated.Objective To compare the incidence of atopic dermatitis ininfants aged 0-4 months with total family atopy scores of > 0 tothose with scores of 0.Methods We conducted this cohort study from June 1, 2012 toDecember 31, 2012 at Sanglah Hospital, Denpasar. Family atopyscore was tabulated from all pregnant woman in the ObstetricOutpatient Clinic and the Maternity Room. Subjects were dividedinto two groups based on their total family atopy score: those withscores > 0 and those with scores of 0. The appearance of atopicdermatitis symptoms in the infants were evaluated until theyreached 4 months of age. The incidence of atopic dermatitis intwo groups was compared using Chi-square test.Results The incidence of atopic dermatitis in this study was 10.9%.The group with total family atopy scores of 0 had a significantlyhigher incidence of atopic dermatitis than the group with scores> 0 (adjusted RR 22.5; 95%CI 8.8 to 57.0; P = 0.001).Conclusion The incidence of atopic dermatitis is higher ininfants with total family atopy score > 0 and this group has a 22.5times higher risk of atopic dermatitis compared to infants withtotal family atopy score of 0. Allergy trace cards are relevant indifferentiating the risk of atopy with regards to development ofatopic dermatitis. We suggest that family atopy scores be evaluatedduring antenatal care in order to limit the development of atopicdermatitis in infants.

Development of atopic dermatitis according to age of onset and association with early-life exposures

2012 ◽  
Vol 130 (1) ◽  
pp. 130-136.e5 ◽  
Author(s):  
Caroline Roduit ◽  
Remo Frei ◽  
Georg Loss ◽  
Gisela Büchele ◽  
Juliane Weber ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Early Life ◽  
Age Of Onset ◽  
Early Life Exposures

scholarly journals Effect of treatments on skin microbiota in patients with atopic dermatitis: a protocol for systematic review

BMJ Open ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. e053488
Author(s):  
Yang Guo ◽  
Xia Dou ◽  
Xing-ling Jian ◽  
Kao-yuan Zhang ◽  
Ying-jie Zheng ◽  
...  
Keyword(s):  
Systematic Review ◽  
Atopic Dermatitis ◽  
Data Extraction ◽  
Risk Of Bias ◽  
Microbial Interactions ◽  
Skin Microbiota ◽  
Clinical Trial Registry ◽  
Bias Assessment ◽  
Study Selection ◽  
Registration Number

IntroductionAtopic dermatitis (AD) is a chronic inflammatory skin disease and skin microbiota dysbiosis shows an important role in the pathogenesis of AD. Effects of treatment on skin microbiota for patients with AD have been evaluated in recent years; however, the results remained controversial across studies. This systematic review will summarise studies evaluating the effect of treatments on skin microbiota among patients with AD.Methods and analysisWe will search PubMed, EMBASE, Web of Science, ClinicalTrials.gov and Chinese Clinical Trial Registry in November 2021; other data sources will also be considered, including searching specific authors and screening references cited in the enrolled articles. Interventional studies, which enrolled patients with AD receiving treatments and reported treatment-related skin microbiota changes, will be included. Our primary outcomes include skin microbiota diversity and treatment-related differential microbes; the secondary outcomes include microbiota functions and microbial interactions. Risk of bias assessment will be performed using Cochrane risk-of-bias tool for randomised trials, risk of bias in non-randomised studies of interventions and methodological index for non-randomised studies. Two researchers will independently perform study selection, data extraction and risk of bias assessment, with disagreements resolved by group discussions. Subgroup analyses will be performed according to different types of treatment for AD.Ethics and disseminationEthics approval is not required for this systematic review. Findings will be disseminated via peer-reviewed publication or conference proceedings.PROSPERO registration numberCRD42021246566.

scholarly journals Impact of early-life rearing history on gut microbiome succession and performance of Nile tilapia

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Yale Deng ◽  
Fotini Kokou ◽  
Ep H. Eding ◽  
Marc C. J. Verdegem
Keyword(s):  
Gut Microbiome ◽  
Early Life ◽  
Nile Tilapia ◽  
Common Garden ◽  
Later Life ◽  
Nutrient Digestibility ◽  
Microbial Interactions ◽  
Microbiome Composition ◽  
Fish Gut ◽  
Growth Trial

Abstract Background Fish gut microbial colonisation starts during larval stage and plays an important role in host’s growth and health. To what extent first colonisation could influence the gut microbiome succession and growth in later life remains unknown. In this study, Nile tilapia embryos were incubated in two different environments, a flow-through system (FTS) and a biofloc system (BFS); hatched larvae were subsequently cultured in the systems for 14 days of feeding (dof). Fish were then transferred to one common recirculating aquaculture system (RAS1, common garden, 15–62 dof), followed by a growth trial in another RAS (RAS2, growth trial, 63–105 dof). In RAS2, fish were fed with two types of diet, differing in non-starch polysaccharide content. Our aim was to test the effect of rearing environment on the gut microbiome development, nutrient digestibility and growth performance of Nile tilapia during post-larvae stages. Results Larvae cultured in the BFS showed better growth and different gut microbiome, compared to FTS. After the common garden, the gut microbiome still showed differences in species composition, while body weight was similar. Long-term effects of early life rearing history on fish gut microbiome composition, nutrient digestibility, nitrogen and energy balances were not observed. Still, BFS-reared fish had more gut microbial interactions than FTS-reared fish. A temporal effect was observed in gut microbiome succession during fish development, although a distinct number of core microbiome remained present throughout the experimental period. Conclusion Our results indicated that the legacy effect of first microbial colonisation of the fish gut gradually disappeared during host development, with no differences in gut microbiome composition and growth performance observed in later life after culture in a common environment. However, early life exposure of larvae to biofloc consistently increased the microbial interactions in the gut of juvenile Nile tilapia and might possibly benefit gut health.

scholarly journals Events in Normal Skin Promote Early-Life Atopic Dermatitis—The MPAACH Cohort

2020 ◽  
Vol 8 (7) ◽  
pp. 2285-2293.e6 ◽  
Author(s):  
Jocelyn M. Biagini Myers ◽  
Michael G. Sherenian ◽  
Asel Baatyrbek Kyzy ◽  
Rosario Alarcon ◽  
Amen An ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Early Life ◽  
Normal Skin

scholarly journals Early life atopic dermatitis increases food allergy risk throughout childhood

2019 ◽  
Vol 143 (2) ◽  
pp. AB125
Author(s):  
Anne Marie Singh ◽  
Christopher J. Tisler ◽  
Lisa Salazar ◽  
Susan Doyle ◽  
Michael D. Evans ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Early Life

Gut microbiome skin axis in the development of atopic dermatitis

2021 ◽  
pp. 1-6
Author(s):  
Hitham Abduarhman Alghamdi ◽  
Ahmed Behieldin ◽  
Sherif Edris
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Gut Microbiome ◽  
Early Life ◽  
Skin Diseases ◽  
Skin Microbiome ◽  
Healthy Skin ◽  
Immunological Activity ◽  
Bacterial Composition ◽  
Strong Relation

Abstract Atopic dermatitis (AD) is the main focus of this review which mostly starts with children in early life. Beside the etiological factors like environmental, dietary or medical exposures, Gut-skin axis microbiome studies have an impact to investigate and to understand the relation between the gut microbiome and changes to the skin microbiom and some skin diseases resulting like AD. Infants start forming their microbiome in early life and some researches suggest that this time have a crucial role in development of AD. Balanced bacterial composition is important to maintain healthy skin as the gut microbiome dysbiosis may result in dramatic shifting in the skin microbiome that gives better chance for some bacteria such as Staphylococcus aureus to over prevail which has been reported to contribute in AD development. Among several factors, immunological activity has a strong relation to microbiome changed composition and development of AD. Continuous....  

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