Systematic review using meta-analyses to estimate dose-response relationships between iodine intake and biomarkers of iodine status in different population groups

2014 ◽  
Vol 72 (3) ◽  
pp. 143-161 ◽  
Author(s):  
Danijela Ristić-Medić ◽  
Carla Dullemeijer ◽  
Jasna Tepsić ◽  
Gordana Petrović-Oggiano ◽  
Tamara Popović ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dose Response ◽  
Iodine Intake ◽  
Population Groups ◽  
Iodine Status ◽  
Meta Analyses

scholarly journals Vegans, Vegetarians, and Omnivores: How Does Dietary Choice Influence Iodine Intake? A Systematic Review

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1606 ◽  
Author(s):  
Elizabeth R. Eveleigh ◽  
Lisa J. Coneyworth ◽  
Amanda Avery ◽  
Simon J. M. Welham
Keyword(s):  
Systematic Review ◽  
Urinary Iodine ◽  
Vegetarian Diet ◽  
Iodine Intake ◽  
Iodine Status ◽  
Secondary Sources ◽  
Increased Risk ◽  
Vegetarian Diets ◽  
Meta Analyses ◽  
Industrialised Countries

Vegan and vegetarian diets are becoming increasingly popular. Dietary restrictions may increase the risk of iodine deficiency. This systematic review aims to assess iodine intake and status in adults following a vegan or vegetarian diet in industrialised countries. A systematic review and quality assessment were conducted in the period May 2019–April 2020 according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies were identified in Ovid MEDLINE, Embase, Web of Science, PubMed, Scopus, and secondary sources. Fifteen articles met inclusion criteria. Participants included 127,094 adults (aged ≥ 18 years). Vegan groups presented the lowest median urinary iodine concentrations, followed by vegetarians, and did not achieve optimal status. The highest iodine intakes were recorded in female vegans (1448.0 ± 3879.0 µg day−1) and the lowest in vegetarians (15.6 ± 21.0 µg day−1). Omnivores recorded the greatest intake in 83% of studies. Seaweed contributed largely to diets of vegans with excessive iodine intake. Vegans appear to have increased risk of low iodine status, deficiency and inadequate intake compared with adults following less restrictive diets. Adults following vegan and vegetarian diets living in countries with a high prevalence of deficiency may be more vulnerable. Therefore, further monitoring of iodine status in industrialised countries and research into improving the iodine intake and status of adults following vegan and vegetarian diets is required.

scholarly journals Dose-response relationship of extended-release methylphenidate for ADHD in adults: post-hoc analysis based on a systematic review

2021 ◽  
Author(s):  
Kim Boesen ◽  
Karsten Juhl Jørgensen ◽  
Peter C Gøtzsche
Keyword(s):  
Systematic Review ◽  
Dose Response ◽  
Extended Release ◽  
Fixed Dose ◽  
Adhd Symptoms ◽  
Post Hoc Analysis ◽  
Using Data ◽  
Meta Analyses ◽  
Post Hoc ◽  
Relationship Of

Objective: To assess potential dose-response relationships of extended-release methylphenidate for ADHD in adults on efficacy outcomes. Study design and setting: Post-hoc analysis based on a systematic review of extended-release methylphenidate (https://doi.org/10.1002/14651858.CD012857). Using data from clinical trials comparing multiple fixed-dose methylphenidate groups with placebo, we conducted subgroup meta-analyses for available efficacy outcomes. Results and conclusion: Five trials used a fixed-dose design with multiple methylphenidate groups receiving different doses. All trials were pivotal industry sponsored studies conducted to obtain marketing authorisation. We analysed four efficacy outcomes: Self-rated ADHD symptoms (5 trials, 1807 participants), investigator-rated ADHD symptoms (5 trials, 1904 participants), quality of life (4 trials, 1158 participants), and peer-rated ADHD symptoms (2 trials, 879 participants). There were no dose-response relationships for any outcome.

Adherence to healthy lifestyles and incidence of diabetes and mortality among individuals with diabetes: a systematic review and meta-analysis of prospective studies

2020 ◽  
Vol 74 (5) ◽  
pp. 481-487 ◽  
Author(s):  
Sabrina Schlesinger ◽  
Manuela Neuenschwander ◽  
Aurélie Ballon ◽  
Ute Nöthlings ◽  
Janett Barbaresko
Keyword(s):  
Systematic Review ◽  
Dose Response ◽  
Healthy Lifestyle ◽  
Meta Analysis ◽  
Lifestyle Factors ◽  
Normal Weight ◽  
Lifestyle Factor ◽  
Health Lifestyle ◽  
Relative Risks ◽  
Meta Analyses

IntroductionLifestyle factors in combination have been hypothesised to be associated with the prevention of type 2 diabetes (T2D) and mortality among individuals with T2D. The aim was to conduct a systematic review and meta-analysis to quantify the association between lifestyle indices and incident T2D as well as mortality in individuals with T2D.MethodsPubMed and Web of Science were searched up to September 2019. We included prospective cohort studies investigating at least three lifestyle factors in association with T2D, or all-cause mortality in individuals with diabetes. We conducted pairwise and dose-response meta-analyses to calculate summary relative risks (SRR) by using random effects model.ResultsIn total, 19 studies were included. Adhering to a healthy lifestyle (mostly favourable diet, physical activity, non-smoking, moderate alcohol intake and normal weight) was associated with a reduced SRR of 78% for T2D (SRR: 0.22; 95% CI: 0.16 to 0.32; n=14) and 57% for mortality (SRR: 0.43; 95% CI: 0.31 to 0.58; n=5) compared with low adherence to a healthy lifestyle. In dose-response analyses, the adherence to every additional healthy lifestyle factor was associated with a reduced relative risk of 32% (95% CI: 28% to 36%) for T2D and 21% (95% CI: 15% to 26%) for mortality.ConclusionsOur findings underline the importance of the joint adherence to healthy lifestyle factors to prevent T2D and improve survival among individuals with diabetes. Adherence to every additional health lifestyle factor play a role in the T2D prevention and progression.PROSPERO registration numberCRD42018091409.

scholarly journals The Dose Response of Taurine on Aerobic and Strength Exercises: A Systematic Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Qi Chen ◽  
Zheng Li ◽  
Ricardo A. Pinho ◽  
Ramesh C. Gupta ◽  
Ukadike C. Ugbolue ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dose Response ◽  
Exercise Performance ◽  
High Dose ◽  
Acute Administration ◽  
Enzymatic Antioxidants ◽  
Taurine Supplementation ◽  
Systematic Analysis ◽  
Lactate Levels ◽  
Meta Analyses

Taurine is a naturally occurring amino acid involved in various functions, including regulating ion channels, cell volume, and membrane stabilization. However, how this molecule orchestrates such functions is unknown, particularly the dose response in exercised muscles. Therefore, this review aimed to systematically review the dose response of taurine on both aerobic and strength exercise performance. In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, relevant articles were sought on PubMed, Medline, Web of Science, and Google Scholar using related terms, including taurine, exercise performance, exercise, muscle, physical training, running, strength, endurance exercise, resistance exercise, aerobic exercise, and swimming. Ten articles were retrieved, reviewed, and subjected to systematic analysis. The following parameters were used to assess exercise performance in the selected studies: creatine kinase (CK), lactic acid dehydrogenase, carbohydrate, fat, glycerol, malondialdehyde, enzymatic antioxidants, blood pH, taurine level, and muscular strength. From the selected literature, we observed that taurine supplementation (2 g three times daily) with exercise can decrease DNA damage. Furthermore, 1 g of acute taurine administration before or after exercise can decrease lactate levels. However, acute administration of taurine (6 g) at a high dose before the start of exercise had no effect on reducing lactate level, but increased glycerol levels, suggesting that taurine could be an effective agent for prolonged activities, particularly at higher intensities. However, further studies are warranted to establish the role of taurine in fat metabolism during exercise. Finally, we observed that a low dose of taurine (0.05 g) before performing strength enhancing exercises can decrease muscular fatigue and increase enzymatic antioxidants.Systematic Review Registration:http://www.crd.york.ac.uk/PROSPERO, PROSPERO (CRD42021225243).

scholarly journals Association of reproductive factors with dementia: A systematic review and dose-response meta-analyses of observational studies

2022 ◽  
Vol 43 ◽  
pp. 101236
Author(s):  
Chunying Fu ◽  
Wenting Hao ◽  
Nipun Shrestha ◽  
Salim S. Virani ◽  
Shiva Raj Mishra ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dose Response ◽  
Observational Studies ◽  
Reproductive Factors ◽  
Meta Analyses

scholarly journals U-shaped relationship between iodine status and thyroid autoimmunity risk in adults

2019 ◽  
Vol 181 (3) ◽  
pp. 255-266 ◽  
Author(s):  
Bin Wang ◽  
Weiwei He ◽  
Qian Li ◽  
Xi Jia ◽  
Qiuming Yao ◽  
...  
Keyword(s):  
Iodine Deficiency ◽  
Dose Response ◽  
Meta Analysis ◽  
Thyroid Autoimmunity ◽  
Epidemiological Studies ◽  
Population Based ◽  
Iodine Intake ◽  
Cross Sectional ◽  
Iodine Status ◽  
Iodine Excess

Background Iodine status has long been regarded as an environmental determinant for thyroid dysfunction, but its relationship with thyroid autoimmunity (TAI) is still controversial. Our study aimed to elucidate the relationship between iodine status and TAI through both a population-based study and a dose–response meta-analysis of eligible epidemiological studies. Methods A population-based, cross-sectional study was firstly carried out, which enrolled a total of 2808 Chinese adults. Odds ratio (OR) with 95% confidence interval (95% CI) was calculated through logistic regression analysis. A dose–response meta-analysis of eligible epidemiological studies was also carried out. Results The cross-sectional study showed an U-shaped relationship between iodine intake and TAI in adults. Compared with those with more than adequate iodine status, individuals with iodine deficiency, adequate iodine status and iodine excess all had higher risk of TAI, and the adjusted ORs were 1.50 (95% CI 1.03–2.17, P = 0.032), 1.50 (95% CI 1.09–2.07, P = 0.013) and 1.68 (95% CI 1.11–2.53, P = 0.014), respectively. The dose–response meta-analysis included 22 epidemiological studies with a total of 69,987 participants and further validated the U-shaped relationship between iodine intake and TAI in adults, which proved the significantly increased risk of TAI among individuals with either iodine deficiency or iodine excess. Stratified analysis of studies with low risk of confounding bias also identified similar findings. Conclusion The study suggests an U-shaped relationship between iodine intake and TAI in adults, and both iodine deficiency and iodine excess are risk factors of TAI in adults. The underlying mechanisms need to be elucidated in future studies.

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