scholarly journals Clinical assessment of gastric emptying and sensory function utilizing gamma scintigraphy: Establishment of reference intervals for the liquid and solid components of the Nottingham test meal in healthy subjects

2017 ◽  
Vol 29 (11) ◽  
pp. e13122 ◽  
Author(s):  
H. L. Parker ◽  
E. Tucker ◽  
E. Blackshaw ◽  
C. L. Hoad ◽  
L. Marciani ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Clinical Assessment ◽  
Test Meal ◽  
Healthy Subjects ◽  
Reference Intervals ◽  
Gamma Scintigraphy ◽  
Sensory Function

scholarly journals Simultaneous Measurement of Gastric Emptying of a Soup Test Meal Using MRI and Gamma Scintigraphy

Diagnostics ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 170 ◽  
Author(s):  
Asseel Khalaf ◽  
Caroline L. Hoad ◽  
Elaine Blackshaw ◽  
Jaber Alyami ◽  
Robin C. Spiller ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Test Meal ◽  
Retention Rate ◽  
Stomach Contents ◽  
Individual Variability ◽  
Gamma Scintigraphy ◽  
Clinical Value ◽  
Significant Difference ◽  
Magnetic Resonance Imaging Mri ◽  
The Individual

Measurement of gastric emptying is of clinical value for a range of conditions. Gamma scintigraphy (GS) has an established role, but the use of magnetic resonance imaging (MRI) has recently increased. Previous comparison studies between MRI and GS showed good correlation, but were performed on separate study days. In this study, the modalities were alternated rapidly allowing direct comparison with no intra-individual variability confounds. Twelve healthy participants consumed 400 g of Technetium-99m (99mTc)-labelled soup test meal (204 kcal) and were imaged at intervals for 150 min, alternating between MRI and GS. The time to empty half of the stomach contents (T1/2) and retention rate (RR) were calculated and data correlated. The average T1/2 was similar for MRI (44 ± 6 min) and GS (35 ± 4 min) with a moderate but significant difference between the two modalities (p < 0.004). The individual T1/2 values were measured, and MRI and GS showed a good positive correlation (r = 0.95, p < 0.0001), as well as all the RRs at each time point up to 120 min. Gastric emptying was measured for the first time by MRI and GS on the same day. This may help with translating the use of this simple meal, known to elicit reliable, physiological, and pathological gastrointestinal motor, peptide, and appetite responses.

Sa1720 Assessment of Gastric Motor and Sensory Function Utilizing Gamma Scintigraphy With the Nottingham Test Meal: Normal Values and Effect of Demographic Variables

2016 ◽  
Vol 150 (4) ◽  
pp. S356-S357
Author(s):  
Helen Parker ◽  
Caroline Hoad ◽  
Elaine Blackshaw ◽  
Luca Marciani ◽  
Emily Tucker ◽  
...  
Keyword(s):  
Test Meal ◽  
Normal Values ◽  
Demographic Variables ◽  
Gamma Scintigraphy ◽  
Sensory Function

scholarly journals The Role of Ultrasonography in the Diagnosis of Functional Dyspepsia

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mirjana Cvetković ◽  
Igor Jovanović ◽  
Slobodanka Crevar-Marinović ◽  
Marija Branković ◽  
Olga Mandić ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Functional Dyspepsia ◽  
Test Meal ◽  
Healthy Subjects ◽  
Metabolic Diseases ◽  
Epigastric Pain ◽  
Postprandial Fullness ◽  
Epigastric Pain Syndrome ◽  
Significant Difference ◽  
Antral Area

Abstract Background: Functional dyspepsia (FD) is a syndrome mostly diagnosed by subjective patients’ symptoms after excluding organic, systemic and metabolic diseases. Aim: The goal of this study is to evaluate gastric emptying in patients with functional dyspepsia, by measuring the antral area (cm2) after the intake of a test meal using ultrasonography as an objective and widely applicable method. Material and Methods: This study included 30 patients (mean age of 46.53 ±9.73 years) with symptoms of FD according to the ROMA IV criteria and 30 healthy individuals (mean age of 42.87 ±4.42 years). A 5 MHz ultrasound probe was used to measure the stomach antral area at 6 different time points: in the fasting state, following the meal intake at 5, 30, 60, 90 and 120 min postprandially. Results: The antral area was statistically significantly larger after a 30-minute postprandial period in patients with FD comparing to healthy controls (p<0.05). There was a statistically significant difference in the rate of gastric emptying at 120 minutes in patients with functional dyspepsia, compared to healthy subjects (p <0.01). Patients with postprandial distress syndrome had the average value of gastric emptying 48.25 compared to 56.09 in patients with epigastric pain syndrome (p <0.05). The slowest emptying was observed in patients with nausea and postprandial fullness (p <0.05). Conclusion: Functional dyspepsia is associated with delayed gastric emptying. Using ultrasonography to measure the antral area helps us to assess gastric emptying and therefore to assess patients with functional dyspepsia. The antral area was significantly larger in patients with functional dyspepsia compared to healthy subjects after the test meal, suggesting slower gastric emptying in the dyspeptic patients. Since the diagnosis of functional dyspepsia is based mostly on diverse patients’ symptoms, using ultrasonography to measure the antral area helps us to objectively assess this problem.

scholarly journals Effect of commercial rye whole-meal bread on postprandial blood glucose and gastric emptying in healthy subjects

2009 ◽  
Vol 8 (1) ◽  
Author(s):  
Joanna Hlebowicz ◽  
Jenny Maria Jönsson ◽  
Sandra Lindstedt ◽  
Ola Björgell ◽  
Gassan Darwich ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Gastric Emptying ◽  
Healthy Subjects ◽  
Postprandial Blood Glucose

Influence of octreotide on the gastric emptying of solids and liquids in normal healthy subjects

2007 ◽  
Vol 9 (1) ◽  
pp. 11-18 ◽  
Author(s):  
B. D. MAES ◽  
Y. F. GHOOS ◽  
B. J. GEYPENS ◽  
M. I. HIELE ◽  
P. J. RUTGEERTS
Keyword(s):  
Gastric Emptying ◽  
Healthy Subjects

13C-octanoic acid breath test (OBT) with a new test meal (EXPIROGer®): Toward standardization for testing gastric emptying of solids

2010 ◽  
Vol 42 (8) ◽  
pp. 549-553 ◽  
Author(s):  
Francesco Perri ◽  
Massimo Bellini ◽  
Piero Portincasa ◽  
Andrea Parodi ◽  
Patrizia Bonazzi ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Test Meal ◽  
Breath Test ◽  
Octanoic Acid

Adaptation to high-fat diet accelerates emptying of fat but not carbohydrate test meals in humans

2002 ◽  
Vol 282 (2) ◽  
pp. R366-R371 ◽  
Author(s):  
K. E. Castiglione ◽  
N. W. Read ◽  
S. J. French
Keyword(s):  
Gastric Emptying ◽  
Dietary Intake ◽  
Test Meal ◽  
High Fat Diet ◽  
Lag Phase ◽  
High Fat ◽  
Free Living ◽  
Gastric Emptying Rate ◽  
High Carbohydrate ◽  
Before And After

Previous work has shown that the gastric emptying rate in animals and humans can adapt due to previous dietary intake. The present study investigated whether adaptation in gastric emptying rate due to consumption of a high-fat diet (HFD) is nutrient specific in humans. Gastric emptying of high-fat and high-carbohydrate test meals was measured (using gamma scintigraphy) before and after consumption of an HFD for 14 days in eight free-living male volunteers. Visual analog ratings of appetite were recorded throughout each test. There was no effect of HFD on any parameters of gastric emptying rate (lag phase, half-emptying time, and linear emptying rate) measured for carbohydrate test meals. HFD led to an acceleration of the linear emptying rate of the high-fat test meal (0.36 vs. 0.47%/min; P < 0.05). All meals reduced appetite ratings, but there were no differences between tests. These results support our previous findings of accelerated gastric emptying of high-fat test meals following an HFD and show that these changes appear to be nutrient specific, confirming recent studies in rats.

scholarly journals Effects of protein on glycemic and incretin responses and gastric emptying after oral glucose in healthy subjects

2007 ◽  
Vol 86 (5) ◽  
pp. 1364-1368 ◽  
Author(s):  
Angela Karamanlis ◽  
Reawika Chaikomin ◽  
Selena Doran ◽  
Max Bellon ◽  
F Dylan Bartholomeusz ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Healthy Subjects ◽  
Oral Glucose
Sign in / Sign up

Export Citation Format

Share Document